DRSC/TRiP Functional Genomics Resources

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Protein Alignment p53 and tp53

DIOPT Version :10

Sequence 1:NP_996267.1 Gene:p53 / 2768677 FlyBaseID:FBgn0039044 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_001001903.1 Gene:tp53 / 431679 XenbaseID:XB-GENE-484286 Length:362 Species:Xenopus tropicalis


Alignment Length:321 Identity:78/321 - (24%)
Similarity:132/321 - (41%) Gaps:59/321 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 NLMQFSQQSVLREMMLQDIQIQANTLPKLENHNI-------GGYCFSMVLDE--PPKSL-WMYSI 219
            |..:||:..:..:|.:....:..||:|.:.:..:       |.|...:...:  ..||: ..||.
 Frog    38 NFAEFSEYPLAPDMTVLQEGLMGNTVPTVTSSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCTYST 102

  Fly   220 PLNKLYIRMNKAFNVDVQFKSKMPIQPLNLRVFLCF--SNDVSAPVVRCQNH-LSVEPLTANNAK 281
            .||||:.::.|...:.|:.:...|:..: ||....:  |..|:..|.||.:| .||||  .::..
 Frog   103 DLNKLFCQLAKTCPLLVRVERPPPLGSI-LRATAVYKKSEHVAEVVKRCPHHERSVEP--GDDPA 164

  Fly   282 MRESLLRSENPNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG--- 343
            ....|:|.|..:..|.....|.|   |.||.||.    ...:.|....|:.:.::|.:||:|   
 Frog   165 PPSHLMRVEGNSKAYYMEDVGTG---RHSVCVPY----EGPQVGTECTTVLYNYMCNSSCMGGMN 222

  Fly   344 RKETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEE-------DE 401
            |:....:..||...|.::|:....|::|.||.|||..:|... :|||...|....|       |.
 Frog   223 RRPILTIITLESPEGLLLGRRCFEVRVCACPGRDRRTEEDNC-TKKRGLKPNGKRELSHPPSSDP 286

  Fly   402 PSKVRRCIAIKTEDT---------------ESNDSRDCDDSAAEWNVSRTPDGDYRLAITC 447
            |...:|.:....|:|               :.||:.:..:|..:          .:|:|.|
 Frog   287 PLPKKRLVEEDDEETFTLLIKGRSRYEMIKKLNDALELQESLDQ----------QKLSIKC 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p53NP_996267.1 P53 193..385 CDD:459972 55/207 (27%)
P53_C 429..495 CDD:314489 3/19 (16%)
tp53NP_001001903.1 P53_TAD 5..28 CDD:462520
P53 84..264 CDD:176262 53/189 (28%)
P53_tetramer 290..332 CDD:462238 6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

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