Protein Alignment GLRA2 and pHCl-2

DIOPT Version :9

• Sequence 1: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 463
• Identity: 131/463 - (28%)
• Similarity: 207/463 - (44%)
• Gaps: 66/463 - (14%)

Human    38 PSQTLSPSDFLDKLMGRTSG---YDARIRP---NFKGP--PVNVTCNIFINSFGSVTETTMDYRV 94
            ||...:.|..|.:|:.|.:.   ||..:.|   |..|.  |:::....:|....::..:.:.:.|
  Fly    62 PSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTV 126

Human    95 NIFLRQQWNDSRLAYSEY-PDDSLDLDPSMLDS-----IWKPDLFFANEKGANFHDVTTDNKLLR 153
            ...|:.::.|.|||:|.| |:..   .|.|.:|     :|.|.:|..||:.:.....:..::|..
  Fly   127 QGLLQLRYLDPRLAFSSYLPNRR---QPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTS 188

Human   154 ISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTL 218
            |..||.||.|.||..||.|.|:.:.||.|.|.|...|||:.|....:...|.:|.||...:.|.|
  Fly   189 IYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQL 253

Human   219 PQFIL---------KEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWV 274
            .::.|         :...| .|.:.....|.::.|.....|.|::|||:|..::||::||.:|||
  Fly   254 TEYNLIGSLYNESIRVSNE-SYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWV 317

Human   275 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVN 339
            |||:..|..|||..||.||:|:..|.|.....:|.|||||...::|..||.:|:|.:|:|:|.||
  Fly   318 SFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVN 382

Human   340 FVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGY-GMGHCLQVKDGTAVKAT--PANPL---- 397
            .:.|::.:....:|..|...|...|....:....|| .....:.....|::..|  |.|.:
  Fly   383 TIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIE 447

Human   398 -----------------------PQPPKDGDAIKKK----FVDRAKR-----IDTISRAAFPLAF 430
                                   ....:..|:.|:|    |.....:     ||...|..|||:|
  Fly   448 TPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSF 512

Human   431 LIFNIFYW 438
            ::||..:|
  Fly   513 IVFNALFW 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	128/455 (28%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		1/4 (25%)
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	131/463 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910