Protein Alignment: GLRA2 and GluClalpha

• Sequence 1: NP_001112357.1
• Gene: GLRA2
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001287408.1
• Gene: GluClalpha
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 190/435 (44%)
• Similarity: 257/435 (59%)
• Gaps: 41/435 (9%)

Human    48 LDKLMGRTSGYDARIRPN----FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLA 108
            ||:::| ...|||||||:    ..||.| |..|||:.|...:.:.||:|.|.:..|:||.|.||.
  Fly    37 LDQILG-AGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99

Human   109 YSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCP 173
            :.:.......|..:..:.:|.|||||:|||..:||::...|..:||..||.||||||::|||:||
  Fly   100 FDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACP 164

Human   174 MDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKEL-GYCTKHYN 237
            |:||.:|:|.|.|::::.|:|:|.|||:|.|....||||.:.|.||:|.|  ||.| .||....|
  Fly   165 MNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTN 227

Human   238 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSS 302
            ||:::|::|....:|:..|||||:|||..::||:||||||::..|.||||:||:||:|||.||:|
  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292

Human   303 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR-------QHKEFLRLRRRQKRQNK 360
            |..||||.|||.||||:|..|||.|||.||||:|.||:.||       .|||.::.:||...|..
  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357

Human   361 EE------DVTRESRFNF-SGYGMGHCLQVKDGTAVKATPANPLP-----------QPPKDGDAI 407
            .:      |....:.|.. |.:..|...|    ..:...|.:||.           |.||..:..
  Fly   358 LDAASDLLDTDSNATFAMASQFARGGGQQ----KPLVRHPGDPLALEKRLQCEVHMQAPKRPNCC 418

Human   408 K---KKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHED 448
            |   .||..|:||||.|||..|||.|.:||:.||.||.....||
  Fly   419 KTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFREEED 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	187/426 (44%)
		Strychnine-binding. {ECO:0000250|UniProtKB:O93430}	236..241		3/5 (60%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	187/426 (44%)
		Neur_chan_LBD	33..241	CDD:280998	90/208 (43%)
		Neur_chan_memb	251..452	CDD:280999	89/205 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3644
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2328
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D276914at33208
OrthoFinder	1	1.000				FOG0000367
OrthoInspector	1	1.000				T609454
orthoMCL	1	0.900				OOG5_128286
Panther	1	1.100			LDO	PTHR18945
Phylome	1	0.910		0.818	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880