DRSC/TRiP Functional Genomics Resources

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Protein Alignment: GLRA2 and pHCl-1

Sequence 1:NP_001112357.1 Gene:GLRA2 HGNCID:4327 Length:452 Species:Homo sapiens
Sequence 2:NP_001261898.1 Gene:pHCl-1 FlyBaseID:FBgn0264908 Length:978 Species:Drosophila melanogaster

Alignment Length:423 Identity:124/424 (29%)
Similarity:197/424 (46%) Gaps:79/424 (19%)


Human    40 QTLSPSDFLDKLMGRTSGYDARI-------------------------RPNFKGPPVNVTCNIFI 79
            ::.|..:.||.|:.: ..||.|:                         ||:.:| .:.|..|:.:
  Fly   333 ESSSDKEILDLLLEK-KRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLL 395

Human    80 NSFGSVTETTMDYRVNIFLRQQWNDSRLAY---SEYPDDSLDLDPSML---DSIWKPDLFFANEK 138
            .|..|..|:::.|.|...|.|||||.||.|   |.|  |.|    :.|   ||||.||.:|... 
  Fly   396 LSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHY--DFL----NALHHHDSIWTPDTYFIMH- 453

Human   139 GANFHD-VTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIF 202
             .:|.| :...:..|||.:||.:.|::|..|.|||...|..||.|...|:..:||..|....:.:
  Fly   454 -GDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKY 517

Human   203 EWLSD-GPVQVAEGL-TLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
            .|.:| ..::.:..| ||..:::|.:...  |.::...|.::|::|:....|...||...::||.
  Fly   518 VWKNDEDTLRKSPSLTTLNAYLIKNQTTA--CDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPG 580

Human   266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330
            :::|..|:::||:..:|.||||.:|:||:|...|.|:|.|::||.||.:.|:::|..||:.|::|
  Fly   581 IILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYA 645

Human   331 ALLEYAAVNFVSRQ---HKEFLRLRRRQKRQNKEEDVTRESRFNFSGYG---------------- 376
            :|||:..||:|.|:   |....|        ..|..||:......|..|                
  Fly   646 SLLEFVCVNYVGRKRPLHNVVYR--------PGENPVTQRLPAVLSRIGVILASPLASAAATPAM 702

Human   377 --MGHCLQVKDGTAVK----ATPANPLPQPPKD 403
              ||....:..||...    |||..|....|::
  Fly   703 SMMGGATPMSSGTPAASSSVATPGTPRITDPEE 735

Known Domains:


GeneSequenceDomainRegion External IDIdentity
GLRA2NP_001112357.1 LIC 46..441 CDD:273305 123/418 (29%)
Strychnine-binding. {ECO:0000250|UniProtKB:O93430} 236..241 1/5 (20%)
pHCl-1NP_001261898.1 Neur_chan_LBD 338..566 CDD:280998 68/240 (28%)
Neur_chan_memb 578..>682 CDD:280999 41/112 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 D614790at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 O PTHR18945
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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