Protein Alignment GLRA2 and pHCl-1

DIOPT Version :9

• Sequence 1: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 124/423 - (29%)
• Similarity: 197/423 - (46%)
• Gaps: 79/423 - (18%)

Human    40 QTLSPSDFLDKLMGRTSGYDARI-------------------------RPNFKGPPVNVTCNIFI 79
            ::.|..:.||.|:.: ..||.|:                         ||:.:| .:.|..|:.:
  Fly   333 ESSSDKEILDLLLEK-KRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLL 395

Human    80 NSFGSVTETTMDYRVNIFLRQQWNDSRLAY---SEYPDDSLDLDPSML---DSIWKPDLFFANEK 138
            .|..|..|:::.|.|...|.|||||.||.|   |.|  |.|    :.|   ||||.||.:|...
  Fly   396 LSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHY--DFL----NALHHHDSIWTPDTYFIMH- 453

Human   139 GANFHD-VTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIF 202
             .:|.| :...:..|||.:||.:.|::|..|.|||...|..||.|...|:..:||..|....:.:
  Fly   454 -GDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKY 517

Human   203 EWLSD-GPVQVAEGL-TLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
            .|.:| ..::.:..| ||..:::|.:...  |.::...|.::|::|:....|...||...::||.
  Fly   518 VWKNDEDTLRKSPSLTTLNAYLIKNQTTA--CDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPG 580

Human   266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330
            :::|..|:::||:..:|.||||.:|:||:|...|.|:|.|::||.||.:.|:::|..||:.|::|
  Fly   581 IILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYA 645

Human   331 ALLEYAAVNFVSRQ---HKEFLRLRRRQKRQNKEEDVTRESRFNFSGYG---------------- 376
            :|||:..||:|.|:   |....|        ..|..||:......|..|
  Fly   646 SLLEFVCVNYVGRKRPLHNVVYR--------PGENPVTQRLPAVLSRIGVILASPLASAAATPAM 702

Human   377 --MGHCLQVKDGTAVK----ATPANPLPQPPKD 403
              ||....:..||...    |||..|....|::
  Fly   703 SMMGGATPMSSGTPAASSSVATPGTPRITDPEE 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	123/417 (29%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		1/4 (25%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	68/239 (28%)
		Neur_chan_memb	578..>682	CDD:280999	41/111 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020