Protein Alignment: GLRA2 and Rdl

• Sequence 1: NP_001112357.1
• Gene: GLRA2
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 174/529 (33%)
• Similarity: 257/529 (49%)
• Gaps: 150/529 (28%)

Human    58 YDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD-DSLDLDP 121
            ||.|:|||:.||||.|...:::.|..|::|..||:.::.:.||.|.|.||||.:.|. ::|.:..
  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134

Human   122 SMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTC 186
            ..:.:||.||.||.|||.:.||..||.|:.:|:..:|.:..|||||:|.||||:|:.||||.|.|
  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199

Human   187 TMQLESFGYTMNDLIFEWLSDG--PVQVAEGLTLPQFILKEEKELGYCTK----HYNTGKFTCIE 245
            .:::|||||||.|:.:.| .||  .|.::..:.||||     :.||:..:    :..||.::.:.
  Fly   200 HIEIESFGYTMRDIRYFW-RDGLSSVGMSSEVELPQF-----RVLGHRQRATEINLTTGNYSRLA 258

Human   246 VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPK 310
            .:....|.|||||||:||||.||||:||||||:|.:|.|||||||:||||||||..|.:.|:|||
  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323

Human   311 VSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR----QHKEFLRLRRRQKRQNKEEDVTRESRFN 371
            :||||:||:::..|.:.|||:|||||.|.::::    :.:.|:.:::..:::.::.|...:.:.|
  Fly   324 ISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQAN 388

Human   372 FS-----------------------------GYGMG---------HCLQVKDGTAVKATPAN--- 395
            .:                             |.|||         |........|.|.|.:|
  Fly   389 PNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPI 453

Human   396 ------------------PL------------------------------PQ------------- 399
                              ||                              ||
  Fly   454 GFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPP 518

Human   400 -----------PPKDG--------------DAIKK-KFVDR-----AKRIDTISRAAFPLAFLIF 433
                       ||:.|              ..:|| |.:::     ...||..||..||:.|:.|
  Fly   519 GGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCF 583

Human   434 NIFYWITY 441
            |:.|||.|
  Fly   584 NLMYWIIY 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	173/527 (33%)
		Strychnine-binding. {ECO:0000250|UniProtKB:O93430}	236..241		2/5 (40%)
Rdl	NP_001261617.1	Neur_chan_LBD	61..>381	CDD:332142	141/317 (44%)
		Neur_chan_memb	274..588	CDD:308533	84/314 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000367
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_128286
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.800