Protein Alignment: GLRA2 and CG12344

• Sequence 1: NP_001112357.1
• Gene: GLRA2
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001286298.1
• Gene: CG12344
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 441
• Identity: 148/442 (33%)
• Similarity: 219/442 (50%)
• Gaps: 73/442 (17%)

Human    37 QPSQTLSPSDFLDKLMGRTSGYDARIR-PNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQ 100
            :|...|.|:            |...|| |:.||.||.|..:||:....|:....||:||::|:.|
  Fly    35 KPRVVLPPN------------YVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQ 87

Human   101 QWNDSRLAYSEYPDDSLD-------LDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNG 158
            :|.:|||   |.|||..:       |.|.:.::.|:||.:|.|.|.|....:|.....:.:.||.
  Fly    88 RWLESRL---EIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNK 149

Human   159 KVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFIL 223
            .|.|:.|:...::|.|:.:.:|||:|.|.:.:|||......:...| ||..|.:...|.|.|:.|
  Fly   150 TVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW-SDSGVTLNPELKLLQYNL 213

Human   224 KEEKEL----GYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAP 284
            .:..||    ||..:  ..|.|:.:.|.|..|||:|::|||.:.||.|:|:|||.|||:.:||.|
  Fly   214 GQPLELEESDGYMPE--KVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIP 276

Human   285 ARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFL 349
            .||.|.:|.:||:.|..:|  |.:|.|:||||:|:|||.|:|.|||||.|:..|..:..|:
  Fly   277 GRVTLLVTCMLTLVTMFTG--ADIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQY---- 335

Human   350 RLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVK--DGTAVKATPANPLPQ------------P 400
                 |.:.|:   :.:......|....|.|..|.  :|.||::..|...|.            |
  Fly   336 -----QYQVNR---IPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGP 392

Human   401 PK-------------DGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYW 438
            ||             |.|...:|.:.|  .||.:|||.||:.|.:|.:.||
  Fly   393 PKPARRQSLLSVAWTDTDTGVEKIMWR--EIDKVSRAVFPILFFVFVLLYW 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	145/433 (33%)
		Strychnine-binding. {ECO:0000250|UniProtKB:O93430}	236..241		1/5 (20%)
CG12344	NP_001286298.1	Neur_chan_LBD	8..441	CDD:332142	147/440 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950		0	Normalized mean entropy	S3841
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR18945
Phylome	1	0.910		0.875	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860