Protein Alignment kl-5 and sac

DIOPT Version :10

• Sequence 1: NP_001015499.4
• Gene: kl-5 / 26067054
• FlyBaseID: FBgn0267433
• Length: 4559
• Species: Drosophila melanogaster
• Sequence 2: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Alignment Length: 1326
• Identity: 243/1326 - (18%)
• Similarity: 451/1326 - (34%)
• Gaps: 487/1326 - (36%)

  Fly   207 KWLDSVEDLVNIKAGEKIYSKENFPLPEAIFSFWESRLENLENLAEQLG-DRRIKTIGFVLEKIQ 270
            :||..:         :|:.....||||..:....::|.....:|.:.:. |||.:.    .:||.
  Fly    80 RWLTLM---------DKMGKAHRFPLPTILPKVIQTRYVPKRHLPKDVEVDRRRRQ----YQKIN 131

  Fly   271 SIFEHSYRRIVELVLESLAEARDI-TKCLSPLKRKMDKFETNDMDENRSDIRPLMLTIGLVWGHS 334
            .:.|.:...:.:.||:...|..:: ::...|.|..:..|:.::.|
  Fly   132 LVNELAKAGLTDDVLQPTEEQYNVMSEFAFPHKFPLSYFDDSNFD-------------------- 176

  Fly   335 RYFHTLNNMTLFFNLFHNSLIDCVNRTVEPDSIFQGDVDEAYKKLDINMQHLEYYKLIYNECRNS 399
                 :|:...:|.|                    |.|.:|:..|... .:|.|.:.:.| |:..
  Fly   177 -----INSPAAWFEL--------------------GVVGDAHYPLPAK-AYLPYNQSLLN-CQWG 214

  Fly   400 LKKFKIGTTFNSQD---WTWHQDEIFGRLDKFLVRLEE--------LKDLF---NTVRDFQKLEK 450
            :    ...|.:.:|   ||             |:.||:        |:.:|   :..:..::|:.
  Fly   215 M----AAVTAHHEDSDLWT-------------LLSLEDGCTYTVPKLQFMFMAEDPHKYIKRLQA 262

  Fly   451 IVMGGLKGRQITFALEKILEEYNSIYREWTNIQYNPIDPDAENSLFQRDRLSFKAKTDVME-RMV 514
            .|....||.|: ..:|.|::   .:..|           |.|:::|    .|||....|:: ..|
  Fly   263 AVHERHKGEQL-MLMELIVD---CVLHE-----------DIESTVF----YSFKPIESVLQAAKV 308

  Fly   515 SFQFEKGLEDTHDLLLAGSLLLRPIIKKHVEPLMHVIVDDFEEEIMCVKKEFINFKNVFTALGLN 579
            |.|.::.|....:|:.              |.||.:.  :.|:.|:.:.|||..|:|:    .|.
  Fly   309 SEQCKRRLRSEVNLVF--------------ERLMALY--ELEQFILKMPKEFPQFRNI----NLK 353

  Fly   580 ELPTDDCFPKVSGAISFLKKLRHRIIGLHKEHELYEYPLFDNERGGYVSDIFNIMVQEIDDFTKM 644
            |.........|||.    ::|..:.:|:..:.:.|:|         ..:.:| ..|..|:....:
  Fly   354 EFLPRSFAVDVSGK----ERLELQALGITMQEKRYDY---------LKASLF-YCVGGIEAMAGV 404

  Fly   645 LLDKWTVECWQGIQQDITLTL--------------IEKDEANE------LRVNFTERLIFALKDI 689
                 .:|| |.|:   ||::              ::..||:.      |:|.:.::|...:  .
  Fly   405 -----AIEC-QYIE---TLSIFICSFSKPLALVDFLQAQEAHSDNVATFLKVYWPQQLTTVI--T 458

  Fly   690 KVVRLLG---CDVSVNL---------------TKFFCREDELWQARVKLMRIA------------ 724
            .|:|.||   .|:|:|.               .||..:|.........||..:
  Fly   459 VVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLE 523

  Fly   725 -----EWYNDTFERAHPTEKRLIAAEMILIEEQMKPLLDFIKWNAFSQRF---IVMIFKMVKYLH 781
                 :|.|:..:...|.:|.:.|..:.:.|::.      :.::.....|   :|.|||
  Fly   524 LKSNYKWTNNYIDTEFPFQKPVFAMTLGISEDRK------VFYSTDPDEFQPGLVEIFK------ 576

  Fly   782 DRLVAAQENLEAIKESIRSWGK---------VPLFQRKDLNPALLLHTDPREPILSIRAANAADT 837
             :.:.....:..|..|:.|:.|         |.|.:.:.|....||.....:.:|.:| |.|...
  Fly   577 -KCLEKSSGVRCIDGSVMSFLKFAPNLYILTVELIEDRFLRENELLKNCYAKAVLPLR-AYARLY 639

  Fly   838 QRLIDLLMYVNLKLFFDIPRRYSLPPGEHGEEDEESDGIWPPIISLSVMTSVKFKKKREVIDEED 902
            :|.||..: :|:..:.....:...|..|                           .||::::.
  Fly   640 ERFIDFYL-LNVNTYMQAYAQAHKPSSE---------------------------VKRDILEN-- 674

  Fly   903 DLEEFEEEQSESEEEIIT--PFH-RYELLKGLSQEER--ALFREYEIYVDEIIAENLVDSVITSS 962
              :..:||..|.....||  ||: ..:.:|....::|  .:.|.:|.|||.:
  Fly   675 --KRLKEELREILPAFITIGPFYINVDTMKQFMIKKRIEVVRRIFEYYVDRM------------- 724

  Fly   963 TYLRMEVDNRYENNTPIFEIFMELQEPNVVYFRNLDTSSKTGFAFFIETILDDMNNMMSLLKRVA 1027
                      ||.|                                 |.:||   ..:.:.:|:|
  Fly   725 ----------YETN---------------------------------EVLLD---RCLEMFRRIA 743

  Fly  1028 QDPTEVTNMNPYSFYDELQDKSELDKQRVEIMNKIKLALQAVRVHGKGFMEFSSL---------- 1082
            :.|..:.::  |...|..|...:|       ::::|..:|.:      ::|:..|
  Fly   744 ERPISIEHL--YEIRDFAQTVPDL-------VDELKADIQVM------WLEYDLLDSFFYNLSDH 793

  Fly  1083 ----------WIWDKSTYLSEVKKFGRNLTLDERDAEADLEGSSGVKLLGLEYPPLSVYKEQLDK 1137
                      |.......||.:|        ||:  :.|:|     ..|.|.......::|:|:
  Fly   794 QFAMKWNVYAWPHQIMVRLSTLK--------DEQ--KVDIE-----DFLRLHASECQAFEERLE- 842

  Fly  1138 FIELQDQI----------RTWETYEDFFVFLRLNMTGFKVAVLSQVGQWISLFKLDLINRVKNSL 1192
              .|.|::          |..||..|      :..|...:..|.:|.|.:. |:.:|......|:
  Fly   843 --SLNDEVQAYSLAFNTNRAQETSVD------IKKTWALIKELEKVSQTLQ-FRQELFELEPLSV 898

  Fly  1193 KELQDFV-------------------DEA---NIVLKIELQKDDFEGLVKILSVLNQ----INEK 1231
            :.|:..:                   ::|   |.:.:::|: |.:..|:::...||:    .:||
  Fly   899 EFLESIIASFTPYKNLWYGCANFLKLEDATLGNPIAQLDLE-DVWNNLMRLRDELNESMKIFHEK 962

  Fly  1232 QCIYDSMFDPLKEIIDLLRQYNYEFKDTELAQINELPDAWMKV--KRLAATTKQLI--APIQSYQ 1292
            ..|.|.....:.:|.|.:..|| ..||..    ||   .||.:  :.|:|.|.|.|  :...:||
  Fly   963 VEIMDVAKTFIAKIDDFVPVYN-SIKDIR----NE---NWMYIHWQELSAITGQEIKYSVAMNYQ 1019

  Fly  1293 VDLIEKRIL-----------LCDNMANTYRKKFLSKKFFFVPCLSCYELIDESDLELVALEERQR 1346
            . ||.|.||           ..:|.|...|:                 .|:|        |||::
  Fly  1020 Y-LIRKGILDVLPEVHIISEKANNEAEEIRR-----------------AIEE--------EERRK 1058

  Fly  1347 SLAESAVLFELQGPDPVKIELCRFDL 1372
            ....:|:|...|      :..||.|:
  Fly  1059 QAELNAMLLRKQ------LRKCRRDI 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kl-5	NP_001015499.4	DHC_N1	198..763	CDD:462457	113/627 (18%)
		DHC_N2	1365..1769	CDD:462462	3/8 (38%)
		DYN1	1591..4206	CDD:227570
		AAA_6	1903..2229	CDD:463697
		MT	3140..3480	CDD:463699
		AAA_9	3508..3726	CDD:463702
		Dynein_C	4261..4557	CDD:465677
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	34/150 (23%)