DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-5 and CG9068

DIOPT Version :9

Sequence 1:	NP_001015499.4	Gene:	kl-5 / 26067054	FlyBaseID:	FBgn0267433	Length:	4559	Species:	Drosophila melanogaster
Sequence 2:	NP_611111.1	Gene:	CG9068 / 36817	FlyBaseID:	FBgn0034106	Length:	1227	Species:	Drosophila melanogaster

Alignment Length:	1345	Identity:	243/1345 - (18%)
Similarity:	473/1345 - (35%)	Gaps:	349/1345 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SLLIGDLL-----PNPLANLSILCDEVFFPLLNNTV-----------------NQVGWTNVIAND 144
            |:.:.||.     ||.:.::....||:.|..|.:.|                 |.:.|...:.|.
  Fly   104 SMCVSDLSYFRREPNEIFSVEGFHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVRNR 168

  Fly   145 MKTESQEMRNGIAQMKGLVINRTIFPLPICMDEVMQAAPAIAMGDISVVNPLMKHSLEFMVVKWL 209
            ..:........::.|...:...::..:|..:.| :.|.|         |:..:..|||.:.:.|.
  Fly   169 FCSSMDRFLAFLSGMHHQISGMSVMYVPFVIKE-LTAGP---------VDRYLVGSLEGIALYWT 223

  Fly   210 DSVEDLVNIKAGEKIYSKENFPLPEAI------FSFWESRLENLENLAEQLGDRRIKTIGFVLEK 268
            ..:..|:         :.:...:|..:      |.|||.|.|.|:.:.:||....::.:..:|..
  Fly   224 TQIRTLL---------ADDTLTVPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLLHN 279

  Fly   269 IQSIFEHSYRRIVELVLESLAEARDITKCLSPLKRKMDKFETNDMDENRSDIRPLML-TIGLVWG 332
            .||:.......::|...:.|.::....|.|..|.....|.:......:.:.:.|.:: .|..:|.
  Fly   280 AQSVHMPQMDGLIERARKELHKSLSNIKYLHLLIEPCSKIDAATSPADLTKLLPRIIHLIRFIWL 344

  Fly   333 HSRYFHTLNNMTLFFNLFHNSLIDCVNRTVEPDSIFQGDVDEAYKKLDINMQHLEYYKLIYNECR 397
            :|.|::|...:...|....|.:|....:..:.:.|..|......:..::.::....|:.||:...
  Fly   345 NSEYYNTTRLIAALFRNLSNQIIRFCTKQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTIS 409

  Fly   398 NSLKKFKIGTTFNSQDWTWHQDE--IFGRLDKFLVRLEELKDLFNTVRDFQKLE------KIVMG 454
            ..|.:       ......|..||  ||..:|.|:.||.::.|:..::..|.:|:      |.|.|
  Fly   410 RDLAQ-------KHTQMPWELDEGLIFNHIDAFVERLNDVIDICESMIVFGRLDENGSIPKPVFG 467

  Fly   455 GLKGRQITFALEKILEEYNSIYREWTN-IQYNP---------IDPDAENSLFQRDRLSFKAKTDV 509
            |..|.:    ||||.|.....:.:..| :|.|.         .|..|:.:.|:::....:   :.
  Fly   468 GTCGEE----LEKIAESVEVQFLDTLNKLQQNSQAYILNVHRADWYADVAGFRKNMQKLE---ET 525

  Fly   510 MERMV--SFQFEKGLEDTHDLLLA---------GSLLLRPIIKKHVEPLMHVIVDDFEEEIMCVK 563
            ::|::  .||....:|:..:.|.|         |:  ||....|....|..:    |.:|:....
  Fly   526 VQRLIFNVFQQVSNVEEMLEALQAMLFYSYRQRGT--LRKTYLKETSKLWRM----FSKEMDATS 584

  Fly   564 KEFIN--------FKNVFTALGL-----------NELPTDDCFPKV---SGAISFLKKLRHRIIG 606
            ::.:.        .|:|..|||.           :.|...:..|.|   |.|::....|||.
  Fly   585 RKLLEEQSRESWLSKHVSIALGYRINLERLTWLRDRLKNSEWLPAVKESSPALAKFDALRHE--- 646

  Fly   607 LHKEHELYEYPLFDNERGGYVSDIFNIMVQEIDDFTKMLLDKWTVECWQGIQQDIT------LTL 665
                        |..|                   .::..|.|..:|. |...|:.      |.:
  Fly   647 ------------FQKE-------------------IRLAYDDWVAKCC-GFSGDLCQRLDRYLVV 679

  Fly   666 IEKDEANELRVNFTERLIFALKDIKVVRLLGCDVSVNLTKFFCREDELWQARVKLMRIAEWYNDT 730
            ..|.....|..|....::...:..:....:|..:...:.|.:.|.|.:......::::|..:|..
  Fly   680 RSKKFKGLLECNIDASVLELCEQAQHFERMGFAIPSTMKKLYERYDTIRSLYNGIIKLALSHNRI 744

  Fly   731 FERAHPTEKRLIAAEMILIEEQMKPLLDFIKWNA-FSQRFIVMIFKMVKYLHDRLVAAQENLEAI 794
            .......|::|....:...:.|:.|.:..|.:.: |::.|.                 ::..|.|
  Fly   745 LAVLSDRERKLFRPLIQACDRQLAPGVFKITYGSEFNEEFF-----------------EDGTEFI 792

  Fly   795 KESIRSWGKVPLFQRKDLNPALLLHTDPREPILSIRAANAADTQRLIDLLMYVNLKLFFDIPRRY 859
            .|          ||               |.:|..:.||.. ..|:.:.:....|..|
  Fly   793 AE----------FQ---------------ELVLIFKRANRG-VARICEKICGTCLLHF------- 824

  Fly   860 SLPPGEHGEEDEESDGIWPPIISLSVMTSVKFKKKREVIDEEDDLEEFEEEQS---ESEEEIITP 921
                                ..|.||                 |:..|:::.|   .|..:|:..
  Fly   825 --------------------AFSGSV-----------------DISVFQQQLSSRLSSSGDILRS 852

  Fly   922 F--HRYELLKGLSQEERALFREYEIYVDEIIAE-----NLVDSVITSS--TYLRMEVDNRYE--- 974
            :  |..|||...|       .:::...||:.||     |.:|.::.||  |..|..::..||
  Fly   853 YYSHVVELLSAFS-------GQFQSVDDEMSAEWIAYVNDMDDMLASSLMTSARGSLNKLYEALH 910

  Fly   975 -----NNTPIFEIFMELQEPNVVYFRNLDTSSKTGFAFFIETILDDMNNMMSLLKRVAQD---PT 1031
                 .:.||..:..::::..:|:..::|     .....|..|:|.:.:|:....|:...   |.
  Fly   911 CDADMASAPIIVVESDVKDGRIVFTPDMD-----AIGDMINGIVDSIRSMLDQFPRLGYKLKLPK 970

  Fly  1032 EVTNMNPYSFYDELQDKSELDKQRVEIMNKIKLALQA-VRVHGKGFMEFSSLWIWDKSTYLSEVK 1095
            :.......|.:.|.|:.|||.:           ::|| :.:..:...::.|.|..::..:.:..:
  Fly   971 KQQRQGFASVFREDQECSELMR-----------SIQAEIGIQREELAKYESEWNKNRVLWQTTEE 1024

  Fly  1096 KFGRNLTLDERDAEADLEGSSGVKLLGLEYPPLSVYKEQLDKFIELQDQIRTWETYEDFFV---F 1157
            :|.:.|....|.|                    .|::..::.:..|.|.:    .:||...   |
  Fly  1025 EFRQRLMSKSRTA--------------------GVFEGGIEHYSALADDV----IFEDAITNVYF 1065

  Fly  1158 LRLNMTGFKVAVLSQVGQWISLFKLDLINRVKNSLKELQDFV--DEANIVLKIE-------LQKD 1213
            :.:|....|..:|..:.:|.:|....|::...|.:..:..::  :|.| |:|:.       ..|.
  Fly  1066 ILINQNALKSTMLDWIEKWQALNIKMLLDHGSNLMGAVYRYMRRNERN-VMKVPRTIRETVAAKQ 1129

  Fly  1214 DFEGLVKILSVLNQINEKQCIYDSMFDPLKEIIDLLRQYNYEFKDTELAQINELPDAWMKVKRLA 1278
            .||.|:|.:.|      ||    |.|.|:.|:..||.:|..:..:....|:..|..||:...::.
  Fly  1130 LFEKLLKDVPV------KQ----SAFTPMLELFVLLHKYQVKLSEETFEQVMGLETAWLHYLQVL 1184

  Fly  1279 ATTKQLIAPIQSYQVDLIEK-----RILLCDNMANTYRKKFLSKK 1318
            ....:::....|....|:.|     :::|.|.:.:.|.|  |.||
  Fly  1185 EEADEMLDNEDSEAKLLLAKHGEKFKLILKDFLEDFYSK--LPKK 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-5	NP_001015499.4	DHC_N1	197..763	CDD:285571	115/629 (18%)
		DHC_N2	1368..1770	CDD:285579
		P-loop_NTPase	1903..2132	CDD:304359
		P-loop_NTPase	2217..2352	CDD:304359
		P-loop_NTPase	2510..2783	CDD:304359
		P-loop_NTPase	2860..3127	CDD:304359
		MT	3140..3480	CDD:289543
		AAA_9	3509..3722	CDD:289547
		Dynein_heavy	3864..4549	CDD:281078
CG9068	NP_611111.1	DHC_N1	211..784	CDD:285571	116/636 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000396
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740