DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kl-5 and kl-3

DIOPT Version :9

Sequence 1:	NP_001015499.4	Gene:	kl-5 / 26067054	FlyBaseID:	FBgn0267433	Length:	4559	Species:	Drosophila melanogaster
Sequence 2:	NP_001104482.3	Gene:	kl-3 / 26067053	FlyBaseID:	FBgn0267432	Length:	4593	Species:	Drosophila melanogaster

Alignment Length:	4730	Identity:	1357/4730 - (28%)
Similarity:	2286/4730 - (48%)	Gaps:	577/4730 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LLNNTVNQVG-WTNV--IANDMKTESQEMRNGIA--QMKGLVINRTIFPLPICMDEVM----QAA 182
            |.::.|:.:| ||.|  :.|:...:::.:.:.:|  .:.....|..:..:...||.|:    :|.
  Fly   137 LRSDLVDLIGKWTVVYRLNNEKSIDNRSVSDEVAIFMISAEERNSCLNVVKTFMDHVLKPSIEAV 201

  Fly   183 PAIAMGD----------ISVVNPLMK---------------HSL--EFMVVKWLDSVEDLVNIKA 220
            ....:.:          :::.|..:|               |.|  ..::|:|        .|:|
  Fly   202 TEFGLAEKEQTQKFFHILNMYNTFLKSSEATVSSRVNFDISHELFKGLLLVRW--------QIEA 258

  Fly   221 GEKIYSKENFPLPEAIFSFWESRLENLENLAEQLGDRRIKTIG---------FVLEKIQSIFE-- 274
            ..||.::..  |.|..|..|..:::.:....:|: .|....:|         .:|.:..:|.|
  Fly   259 SSKILTRVR--LVERYFEQWLRQIQGILVEGKQI-QRDTPDVGPLQMLVNWRRMLARYTTITEFV 320

  Fly   275 ---------------------HSYRRIVELVLESLAEARDITKCLSPLKRKMDKFETNDMDENRS 318
                                 :.:..|...|..:|.||:|..:.:|.|::..|....:..:...|
  Fly   321 TSRAFNNHKDCLTLSRSSKLLNRWAEIDNQVTLALNEAKDNVRYISSLQKFWDPLYRSSPNVIIS 385

  Fly   319 DIRPLMLTIGLVWGHSRYFHTLNNMTLFFNLFHNSLIDCVNRTVEPDSIFQGDVDEAYKKLDINM 383
            .:..||:.|..|...:.||:|..|:|.......|.|      |:...:..   .|..:.|:
  Fly   386 SLPGLMVAIRNVSKTAHYFNTPVNVTGLMVKISNQL------TITSKNYI---TDNEHSKV---- 437

  Fly   384 QHLEYYKLIY----NECRNSLKKFKIGTTFNSQDWTWHQDEIFGRLDKFLVRLEELKDLFNTVRD 444
              :|.||.||    :|.:||          |.:.||.....|...|.|||.|||::|.:.||...
  Fly   438 --MENYKNIYIHTVDEMKNS----------NERPWTVSSVYILTCLQKFLQRLEKVKWIANTDIT 490

  Fly   445 FQKLEKIVMGG-------LKGRQITFALEKILEEYNSIYREWTNIQYNPIDPDAENSLFQRDRLS 502
            :..|::|::.|       :||.::|.:.:                .|:|:     |...:...|.
  Fly   491 YSILDRIMISGMERFNAMIKGARMTISSQ----------------LYDPL-----NYRIETFDLD 534

  Fly   503 FKAKTDVMERMVSFQFEKGLEDTHDLL-----LAGSLLLRPIIKKHVEPLMHVIVDDFEEEIMCV 562
            |:...:.:|     :.|.|::....||     .|.|::|   :.|..|.|        ..|.:|:
  Fly   535 FEKFVNEVE-----EAEVGMQQFVKLLSTECPSAASVML---VLKRFEAL--------SLECLCL 583

  Fly   563 KKEFIN-----------FKNVFTALGLNE------LPTDDCFPKVSGAISFLK------------ 598
            .:.::.           .|:|:     ||      :|.:  .|.|:|.|.:::
  Fly   584 DRRYLEVAEMLEREMFLLKDVY-----NEERGNPFIPRN--LPPVAGRIIWIRSIFKKIDLPMQA 641

  Fly   599 -KLRHRIIGLHKEHELYEYPLFDNERGGYVSDIFNIMVQEIDDFTKMLLDKWTVECWQGIQQDIT 662
             |||..::...|......|              :|.|...|..: :|...|    .|....:::.
  Fly   642 LKLRQCVLAHKKAQRTVRY--------------YNYMNGIICHY-EMAYHK----AWFDYVEEVR 687

  Fly   663 LTL------IEKDEANELRVNFTERLIFALKDIKVVRLLGCDV-SVNLTKFFCREDELWQA-RVK 719
            ..|      |.|:||..: ||....::..:.:.:.:..|..:| ::..|..:|::..|..| .:|
  Fly   688 CLLNAPIMTINKEEAIYI-VNIDRAILQLISETEWMWKLNLEVPNMAATITYCKDRLLGPATTLK 751

  Fly   720 LMRIAEWYNDTFERAHPTEKRLIAAEMILIEEQMKPLLDFIKWNAFS-QRFIVMIFKMVKYLHD- 782
            ||  .:.|:.......|....::...:..|...:||.|..:.|.:.: :.::..:...:|.:..
  Fly   752 LM--LQRYDRLRTSLTPVFINIMRFRLQEISILLKPSLSTVTWISENLEDYVEKVCMKIKEVETF 814

  Fly   783 -RLVAAQENLEAIKESIRSWGKVPLFQRKDLNPALLLHTDPREPILSIRAANAADTQR------- 839
             .|:...|:|..::|..            .::..|.::. |.||:.|......::..|
  Fly   815 FNLILDIEDLRILQEMY------------SISDYLYIYV-PEEPVSSYEFVEESNKLRSEIERIL 866

  Fly   840 ----------LIDLL-MYVNLKLFFDIP----RRYSLPPGEHGEEDEESDGIWPPIISLSVMTSV 889
                      ::|:: |:::|..|....    |.:.|||.:..:.:..::|..|    :.....:
  Fly   867 EKKSVCMERAVVDIINMFIDLLDFEQTDSKGRRVFQLPPEKLNDTNWRTEGFLP----IDKWDFI 927

  Fly   890 KFKK--KREVIDEEDDLEEFEEEQSESEEEIITPFHRYELLKGLSQEERALFREYEIYVDEIIAE 952
            :|.|  :...:..||.|...   |..:.|.|     ||||.. |..:...||..|...:  |:|
  Fly   928 QFHKIYRTIYLAPEDVLRTL---QFRNYENI-----RYELYH-LRNDCMDLFSYYNSKI--ILA- 980

  Fly   953 NLVDSVITSSTYLRMEV-DNRYENN--TPIFEIFMELQEPNVVYFR-NLDTSSKTGFAFFIETIL 1013
             ||.....|..::|..: ...:..|  .||....:|:...|..|.: ||            |.:.
  Fly   981 -LVAGSKRSLDFVRQNILRTNWRTNPMKPILHTDLEIDFYNGCYIQPNL------------EIMQ 1032

  Fly  1014 DDMNNMMSLLKRVAQDPTE----VTNMNPYSFYDELQDKS-ELDKQRVE------IMNKIKLALQ 1067
            :|.||.:...       ||    |:.....:...|.:|:. .:|:.:.|      :|.. |..::
  Fly  1033 NDFNNAVLCC-------TEINYFVSTWGKQAKTQERRDRRVTVDENKYERSYFRYVMEH-KDVIR 1089

  Fly  1068 AVRVHGKGFMEFSS---------------LWIWDKSTYLSEVKKFGRNLTLDERDAEADLEGSSG 1117
            ||:....|.:.:.|               ||..|:...::.. .....||:|.||
  Fly  1090 AVQNLANGLLSYKSDMEEFQRDMFEKYKYLWAEDREDIINSF-VLTNPLTVDIRD---------- 1143

  Fly  1118 VKLLGLEYPPLSVYKEQLD-KFIELQDQIRTWETYEDFFVFLRLNMTGFKVAVLSQVGQWISLFK 1181
               :.|.|..:|:..|.:. |.|....::|...|.|               .::|:..:|..|..
  Fly  1144 ---MFLHYDNISLKIETMSAKRIIGPIEVRMGSTIE---------------KLVSESKKWKVLLG 1190

  Fly  1182 LDLINRVKNSLKELQDFVDEANIVLKIELQKDDFEGLVKILSVLNQINEKQCIYDSMFDPLKEII 1246
            ..|..:.|..|.|:.:|:.|.|.:|...:  :|.:.:.:.:.||.::.:.....|.....:.:..
  Fly  1191 HLLSVQYKKQLDEMIEFITEQNNILDKPI--NDLDDVRQAMVVLEKVRDNYIEMDVSLQLITDTY 1253

  Fly  1247 DLLRQYNYEFKDTELAQINELPDAWMKVKRLAATTKQLI--APIQSYQVDLIEKRIL--LCDNMA 1307
            .|..|: |.:...|         .:.||:.|.....:::  |...|.::..:|:.:|  |.|.:|
  Fly  1254 SLFSQF-YIYVPQE---------DYDKVEGLQVLFNKMLENAKKVSDRISEMEEPLLRELNDGIA 1308

  Fly  1308 NTYRKKFLSKKFFF------VPCLSCYELIDESDLELVALEERQRSL---AESAVLFELQGPDPV 1363
             |:.::|......|      |..:|..|..|...|.....:|..|..   :....||.|...|..
  Fly  1309 -TFVQEFYDFNLDFDLNGPMVEGISAKEASDRVFLFQNRFDELWRKFEMYSSGEKLFGLPITDYP 1372

  Fly  1364 KIELCRFDLKLVKIMWDFAITIQSTINDWKKTPWKKIDIENMDQECKKFGRELRGLDKAMRTWEP 1428
            .:...:.:...:..::...|.:..||.|:.:.||..::||.:..|...|....|.|.|.|::|..
  Fly  1373 LLHQRKREFNYLNRLYSLYIQVLKTITDYYEMPWADVNIEKISAELSDFQLRCRKLPKGMQSWPA 1437

  Fly  1429 FIFMEASLKNLMTSLRAVTELQNPAIRDRHWIEL-------MQTTKVKFSMDDSTTLKDLIDLNL 1486
            ||.::..:.:...:...:..:.|.|:::||||.|       ...|..||      ||..|::..:
  Fly  1438 FIDLKTKIDDFNETCPLLELMTNKAMKERHWIRLNALFNTDFDPTNPKF------TLGKLLEAPI 1496

  Fly  1487 HEYEEEVKNIVDKSVKEMAMEKQLRDIATAWG--TMEFGTDIHDRTSIKLLKASE--ELIETLED 1547
            .:|:|:|::|...:.||:.:|.:|:.|.:.|.  :::.| ...:|..: :||..|  |:|.:|||
  Fly  1497 LKYKEDVEDICVGASKELDIEAKLKQIVSDWSLVSLQLG-QFKNRGDL-VLKGGETLEIISSLED 1559

  Fly  1548 HQGQLQNMASSKYIAFFEHEVRLWQNRLSNADQIIGSWFEVQRKWQYLESIFIGSEDIRSQLPED 1612
            ....:.::||::|.|.|:.:::||.::|.|...|:..|..||..|.|||::|:|. ||..|||.:
  Fly  1560 SLMIMNSLASNRYNAPFKKDIQLWLSKLVNTGDILEKWLMVQNLWIYLEAVFVGG-DISKQLPME 1623

  Fly  1613 SRRFDYIDKEFKALLAQMNADRNVVRSTNRSGSKLYEHLEILLKMLLLCEKALNDYLETKRLSYP 1677
            ::||..|||.:..::.:.....|.|.......| |..:|..||..|..|:|:|..|||:|||.:|
  Fly  1624 AKRFTNIDKSYVKIMMRAREIPNAVDCCTGDES-LATNLTWLLDQLETCQKSLTGYLESKRLVFP 1687

  Fly  1678 RFYFVSSADLLDILSNGNNPALVARHLTKLYDSMGKLNLISGSKNAAGMVAKELEEYVPFLENCD 1742
            ||:|||...||:||...::|..:..||..::|::..::....|.:....:.....|.|.|.....
  Fly  1688 RFFFVSDPVLLEILGQASDPTSIQPHLLSIFDAIATVDFQEKSIDIIESMNSMNREKVKFENTVQ 1752

  Fly  1743 CSGKVEVWLNRITDKMRDTLRDQL-KRSLTFYDHKPRHVWIFEWPA---QPALVGTQIMWTTETN 1803
            |.|.||:||.|:..:|:||:|..| :.|::..|  |...:..|:|:   |..:||.|::||.::.
  Fly  1753 CLGSVELWLGRLLKEMQDTIRTILAQMSVSLND--PEFNFAEEFPSFCGQAGVVGVQLLWTKDSE 1815

  Fly  1804 DAFAKVQQRYENALKDYNKKQITQLNNLIILLLGDLTAAERQKIMTICTIDVHSRDVVGTIIAKK 1868
            .|..|.:.. :..:|..|.|.:..||..|.|.:.|||:.:|.:..|:.||.||.||:...:...:
  Fly  1816 YALRKCRTD-KTIMKRTNNKFLVLLNFFIDLTVKDLTSLDRIRFETMVTIHVHQRDIFDDLCTLR 1879

  Fly  1869 VEVQTAFQWQSQLRHRWDPKIDDCFANICDAQFRYDYEYLGNTPRLVITPLTDRCYITLTQSLHL 1933
            ::....|:||.|.|..::...||....|.|..|.|..||||.|.||.||||||||||||.|::.:
  Fly  1880 IKSAGDFEWQKQARFYYNEDNDDVIVGITDVNFVYQNEYLGVTERLAITPLTDRCYITLAQAVGM 1944

  Fly  1934 VMGGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGDIHKGLAQTGAWGCFDEFNRI 1998
            .|||||||||||||||||||:|||||.:|.|||||:|||::.:|.|:|||||:|:||||||||||
  Fly  1945 CMGGAPAGPAGTGKTETTKDMGRALGKLVVVFNCSDQMDFRGLGRIYKGLAQSGSWGCFDEFNRI 2009

  Fly  1999 SVEVLSVVAVQVKCIQDAIKSKKQTFSFL-GEHIALRTTVGVFITMNPGYAGRAELPENLKALYR 2062
            .:.||||.|.|:..:..|.|.|:.||.|| |:.::|....|:|||||||||||.|||||||.::|
  Fly  2010 ELPVLSVAAQQIYIVLTARKEKRSTFIFLDGDIVSLNPEFGIFITMNPGYAGRQELPENLKIMFR 2074

  Fly  2063 PCAMVVPDFALISEIMLVAEGFQEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGA 2127
            ..||:|||..:|..:.:.:.||:|..:|:||..|||.||:|.||||.|||:|||.|.|||...|:
  Fly  2075 TVAMMVPDRQIIIRVKMASCGFKENVVLSRKMYTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGS 2139

  Fly  2128 LRRDDRQRPEDQVLMRALRDFNIPKIVTDDVPVFMGLIGDLFPALDVPRKRNPEFEAVIKRSALD 2192
            .:|.:....|:.::||.|||.|:.|::.:|..:|:.|:.|:||.:.:......:.:..|
  Fly  2140 QKRSNPNDTEETIVMRVLRDMNVSKLIDEDEGLFVSLVDDMFPGIKLTTNVYKDLQKAI------ 2198

  Fly  2193 LKLQPEDGFI------LKIVQLEELFAVRHSVFIIGFAGTGKSEVWKTLNKTYQNQKRKPHYNDL 2251
            :|:..|.|::      ||:|||.|...|||.:.::|..|:||:.....:.:.:....|......:
  Fly  2199 IKVCDELGYVNNPEWNLKVVQLYETSLVRHGLMLMGPTGSGKTSCTVCMLRCFTEMGRTHKEMRM 2263

  Fly  2252 NPKAVTNDELFGIVNPSTREWKDGLFSILMRDQANLGGTGPKWIVLDGDIDPMWIESLNTVMDDN 2316
            ||||:|..::||.::.:|.:|.||:||.|.|....:......||||||.:|.:|||:||:|:|||
  Fly  2264 NPKAITAPQMFGRLDVATNDWTDGIFSTLWRRSLKVPQHQNCWIVLDGPVDAVWIENLNSVLDDN 2328

  Fly  2317 KVLTLASNERIALTKEMRLLFEIASLRTATPATVSRAGILYINPQDLGWTPFIQSWLGTRTNSSE 2381
            |.||||:.:||.:....:|:||..::..|:||||||.|:::.:...|.|..::::||..:...||
  Fly  2329 KTLTLANGDRIKMADNSKLVFEPDNVDNASPATVSRVGMVFTSSSVLSWKIYMEAWLLKQGEDSE 2393

  Fly  2382 V--SMLNVLFDKYVPPLLDIF-RTRLRSITPISDIARLQMTCYLLDSMLTPQNVPNDCP---KDW 2440
            |  ...:||:|.     ..:| ::||.:...|.:...::....::|.:|.      |.|   :..
  Fly  2394 VFRRCYDVLYDD-----AHVFLQSRLLAKMRILEAIYIRQMLDIMDGLLL------DLPLRTEKA 2447

  Fly  2441 YEIYFVFCIVWGFGSSLFQDQIIDWSNEFSKWFLNEYKAVKFPLSG---TIFSFYIDHETKKFFP 2502
            .|..|:|.::|..|:.|...:    ..:..::.|.....:::|..|   |||.:|:| :...:..
  Fly  2448 LERIFLFSLMWSLGAVLELSE----REKLEEFLLKHVSKLRWPKRGVNETIFEYYVD-DNGNWQH 2507

  Fly  2503 WTNLVPQFELDMD-LP-LQSNLVNTAETTRLRFFMDTLIEADHPLMLIGPSGSGKTILMNAKLSA 2565
            |:..|.:|....| :| ..|.||...:..|..|.:..:.:....::|||..|:.||:::.|.:..
  Fly  2508 WSTRVEEFRYPEDEIPEFSSILVPNVDNVRTAFLLHNIAKQLKQVLLIGEQGTAKTVMIKAYMGH 2572

  Fly  2566 LPSDKYSVTNVPFNFYTTSEMLQRILEKPLEKKAGRNYGPIGNKRMIYFVDDMNMPEVDKYFTVQ 2630
            ...:.:...:..|:..||..|.|||:|..:||:.|..|||...:.|..|:||:|||.::::....
  Fly  2573 YDPEVHIFKSFNFSSATTPNMYQRIIESYVEKRQGTTYGPPNQRAMTIFIDDINMPVINEWGDQI 2637

  Fly  2631 PHTLIRQFMDYHHWYDRQK----MTLRDIHKCNIVACMNPSAGSFTIDPRLQRHFCSFAVNPPSQ 2691
            .:.::||.::...:|..::    .|:.||..  :.|.::|..|...|..||:||.|.|....||.
  Fly  2638 TNEIVRQMIEQRGFYSLERPGDFSTIMDIQM--LSAMIHPGGGRNDIPNRLKRHLCIFNCTLPSN 2700

  Fly  2692 DALFHILNSILSQHMDNPIQKFDKAVIKLCENMVTTAITLHLKVVSSFLPTAIKFHYNFNLRDIA 2756
            :::..|..||.:.:. :|.:..|: |:::...:|.........|.:..|||...|||.|||||::
  Fly  2701 NSMDQIFKSIGAGYF-SPDRLGDE-VVEVIPLLVPLTRIFWQNVKAKMLPTPANFHYVFNLRDLS 2763

  Fly  2757 NIFTGVLYSNSETCPNSNQMIRLWIHECYRVYGDKLVDYTDINSF-KKIVSDI------------ 2808
            .|:.|:|....|.|.:.:|:::||.|||.||..|:.....|...| .|::||.
  Fly  2764 RIWEGILKVKHEECKSVDQILKLWCHECTRVISDRFTAEKDKIWFSSKMISDAELNIKEFMEFYP 2828

  Fly  2809 ------------VRKGIEGVNDDVVYAQPLIYCHFAKGLTDIKYMPISGWDRLKSLLDEAQDRYN 2861
                        ..:|.|..::::.:..|.|            |..|..:|.::|.:.....::|
  Fly  2829 EEPTYWVDFLRDAPEGQEEEDEEMSFEPPKI------------YEEIPSFDFVRSKVLVFMSQFN 2881

  Fly  2862 DYIGA--MNLVLFDDAMSHVCRISRILESSRGYALLIGVGGSGKQSLTRLASFISSLDVFQIQLT 2924
            :||..  |:||.|.||:.|:..:|||:.:.||.|||:|||||||||||||:|||:....||:.||
  Fly  2882 EYIRGYNMDLVFFMDALKHLMIVSRIISNPRGNALLVGVGGSGKQSLTRLSSFIAGYKFFQMTLT 2946

  Fly  2925 KDYSVSDLKANIATLYMKAGVKTSACCFLMTDSEVAREQFLVLVNDLLASGDIHELFPDDEVENI 2989
            :.|:..:|..::..||..||:..:...|:.|.:|:..|.||..:|::|:||:|..||..||::.:
  Fly  2947 RSYNTGNLTEDLKFLYRTAGLDGNGMTFIFTANEIKEESFLEFINNILSSGEIANLFAKDELDEM 3011

  Fly  2990 VNAVRNEVK--QLGIVDNRENCWKYFIEKVRSLLKVVLCFSPVGATLRVRSRKFPALVNCTTIDW 3052
            .:.:...:|  |......::|.:.:||.:.|..|.:.|||||||...|:||.|||.|::...|||
  Fly  3012 YSELIPVMKKHQPRRPATQDNLYDFFISRARYNLHIALCFSPVGEKFRMRSLKFPGLISGCVIDW 3076

  Fly  3053 FHEWPQQALESVSLRFLSEITVLPKE-LALPVSNFMAFVHKTVNDISKLYLANAKRYNYTTPKSF 3116
            |.:||:.|..:||..:|::..::..| :...|.:.|:::|::|.:....|....:|..:.||||.
  Fly  3077 FQKWPEDARIAVSRHYLTDYQIVCSEKVKDQVIDIMSWIHESVQETCLSYYDRFRRVTFVTPKSL 3141

  Fly  3117 LELIALYSKLLHEKVKANLDRRLRLENGLIKLASCTKEVDAL-QDVLKVQEVELKIKNQEADNLI 3180
            :..:..|..|..:|....:....|:.:||.||......|..| :|::::.:| :.:.::||::::
  Fly  3142 ISFLESYKLLYKDKQDHIVIMSERMSSGLDKLDEAGASVAILKKDLIEMNKV-IALASEEAEDVL 3205

  Fly  3181 IVVGTENEKVSKE--RAFASKEEKNVRQIEEDVTAKAKLCEEDFLKAQPALIAAQEALNTLNKNN 3243
            ..|  |..|.:.|  :...::::.....:.::::|...:.|....||.|||..|:.||.|:...:
  Fly  3206 ATV--EQSKAAAEIVKVEVAEKKGQAEVLVKNISAVKHVAEAKLEKALPALEEAEAALKTIKAAD 3268

  Fly  3244 LTELKSFGSPPDAVVSVCGAVLVLFSSKGK-IPKD-------RSWKACRAFMGNVDKFLDNLINY 3300
            :..::..|.||..:..:...|.:||..|.| |..|       .||......|.:. .||..::.|
  Fly  3269 IATVRKLGKPPYLITLIMDCVCILFRRKVKPIRPDTEKAFIQSSWDESLKVMSDT-SFLRKIVEY 3332

  Fly  3301 DKKHIHPDVIKALQPYILDAEFSPEKILAKSSAAAGLCSWVININRFYDVYLVVEPKERALLESE 3365
            ....|:.:::..:.||....:::.|.........|||.||.:.::::::|...|.|.:..|...|
  Fly  3333 PTDLINAEMVDMMVPYFQYPQYTFEAAKVACGNVAGLLSWTMAMSKYFEVNKEVLPLKANLAVQE 3397

  Fly  3366 KEVKDARDKLTALNLRLTELEEQLNALQMEYDEALAKKQKCQDEASKTAFTIDIANRLIGGLATE 3430
            .:.:.|...|......|.:.|.:|..:|...::|::||....|||.|....:|.|..||||||.|
  Fly  3398 AKYQKASSDLQEAEELLQQKENELAEVQQTLEDAVSKKDAVLDEAKKCQDKMDAATALIGGLAGE 3462

  Fly  3431 KIRWMESVKVLTFGIQQLPGDILIISCFISYVGCFTRAYRQELQEKLWMPAFKNSQPPIPSTDGV 3495
            ||||.|.:........:|.||:::::.|:||.|.|.:.:|.:|| .:|....  .:..||.:..|
  Fly  3463 KIRWTEQIASFKSETDRLVGDVILLTAFLSYTGPFNQEFRSDLQ-SIWTKQI--IEKMIPISANV 3524

  Fly  3496 DPFEMICDDAQIAEWNNQGLPSDRMSAENAAILVQSERYPLMIDPQLQGIKWVKTKYGTG-LVVL 3559
            :..|.:.|.:||.|||.||||:|.:|.:|..|..::.|:||:||||.||..|:|.|.... ::|.
  Fly  3525 NIIESLTDRSQIGEWNIQGLPTDELSIQNGIISTKAMRFPLLIDPQSQGKVWIKNKEKQNKVIVT 3589

  Fly  3560 RLSQRNYLDQVERAVSNGSVLLIENIGENIDPVLNPLLGRQLIKKGT--VLKIGDREIDFNSRFR 3622
            .|:.:.:.:.:|.:||.|..::||::.|.:||.|:.||.|.|:|.||  .:||||:|:|:|..||
  Fly  3590 TLNHKYFRNHLEDSVSMGIPIIIEDVAEELDPCLDNLLDRNLLKVGTQYKIKIGDKEVDWNPAFR 3654

  Fly  3623 LILHTKLANPHYKPEMQAQTTLINFTVTRDGLEDQLLAEVVKVERPDLEAMRTRLTQQQNHFKIT 3687
            ..:.|||.||.|.||:.|:|::|:||||..|||||||..|:..||.:||..|.:|.:........
  Fly  3655 CYITTKLPNPAYTPEIFARTSIIDFTVTMRGLEDQLLGRVILAERKELEDERVQLVETVTGNMKK 3719

  Fly  3688 LKFLEDDLLARLSSAGDNVLEDVTLVMNLEKTKKTADEIEVKVAEAKITGVQIDSAREAYRPAAE 3752
            :|.||.:||.:||:...::|:|||::..|..:|.||.|::.|:..||:|..:|::|||.||..|.
  Fly  3720 MKELEANLLQKLSTTKGSLLDDVTVIEVLNTSKNTAIEVKEKIEIAKVTEAKINAAREEYRVVAT 3784

  Fly  3753 RASIIYFILNDLFKINPIYQFSLKAFTVVFNNAMLKAMAAEKLKDRVENLIDSITFCSFVYTSRG 3817
            |.|::||::..:.::|.:||.||..|...|:.:|..:......:.|::.:|:.:||..:.|.|||
  Fly  3785 RGSVLYFLVCSMARVNNMYQTSLVQFLERFDASMYNSSKTHITQKRIKRIINYLTFEIYRYKSRG 3849

  Fly  3818 LFEQDKLIFLTQLCIQILVNLGEVEPTELDFLLR---------FPYMPNQTSNFTWLTHVGWGGI 3873
            |:|:||.:|:..:.:.|...|..:...|....::         .|.:|     |.|.|...|..:
  Fly  3850 LYEKDKFLFVLLMALSIDRQLELITFDEFQVFIKGGAALNLNDCPPVP-----FRWTTDETWLNL 3909

  Fly  3874 RALNNQAVFKGLEKDIEGSHKRWKKFVDSESPENEKFPGEWKGKSAIQRLCIMRCIRPDRMSYAM 3938
            ..|.|...|..:...:.|:.:.|..:...::||||..|..:......:::.::|....||.....
  Fly  3910 VQLTNLTPFVNILSKVSGNERAWFTWYKKDAPENEIIPDGYNSLDPFRKMLLVRSWCMDRTISQC 3974

  Fly  3939 RSFIEEKLGSKYIDARSMEFSRTFEESSPETHIFFVLSPGVDPLKDVEKLGKSLGFSFDHENFHS 4003
            |.:|...||.::.:...:.|.....||.....:...||.|.||..::|.|.|.     :....|.
  Fly  3975 RKYIANSLGDRFAEPVVLNFEELLLESRELMPMICFLSLGSDPSSNIELLAKK-----NELKCHP 4034

  Fly  4004 VSLGQGQEIVAENAIEIASQYGHWVILQNIHLVARWLPS-----LEKKMESSLSNVHTSYRLFLS 4063
            :|:||||||.|...|....:.|.||:|||.||...::..     ||.:.:...:.|:.::|::::
  Fly  4035 ISMGQGQEIHARKLILSCLEDGGWVLLQNCHLGLEYMVELTVQILELERQGKDAAVNPNFRIWIT 4099

  Fly  4064 AEPAGDPAAHILPQGILESAIKITNEPPTGMMANIHKALDNFSDETLEMCSKETEFKAILFSLCY 4128
            .||  .|.   .|..:|:..:|.|||||.|:.|.:.:...|.|.:.|:. |:...:..:::|:.:
  Fly  4100 TEP--HPK---FPITLLQMCLKYTNEPPAGIRAGLKRTYTNLSQDFLDY-SQSPFYLPLVYSISF 4158

  Fly  4129 FHAVVAERRKFGPQGWNRSYPFNVGDLTISVYVLYNYL---EANTRVPWEDLRYLFGEIMYGGHI 4190
            .|.||.|||||||.|||..|.||..|...|...:.|:|   |....:.|..:||:.||:.|||.:
  Fly  4159 LHTVVQERRKFGPLGWNIPYEFNSSDWYASCLFVQNHLDDIEQGKGISWVTVRYMLGEVQYGGRV 4223

  Fly  4191 TDDWDRRLCRTYLEEFMQPELIDGELEYCQGFPAPGILKYTGYHNYIDDNLPSESPSLYGLHSNA 4255
            |||:|:||..|:...:....|.:...::.:|:......:...|...|||....:.|.:||.||||
  Fly  4224 TDDYDKRLLNTFTRVWFHDTLFEDCFQFFKGYKVYSFKEQEAYLAAIDDMANVDPPQVYGFHSNA 4288

  Fly  4256 EIGFLTTVSERLFRIVFELQPRMTGGSSGGETVSQEDIIKNIIEDILDKTPTPFNILEL------ 4314
            ||.:.|.....:...:..:||:   .||.|...|:||.:...::::|.|||..|::.::
  Fly  4289 EITYQTNTMRNILDEIMSIQPK---ESSAGTGESREDRVARQVKEMLSKTPLAFDLFDVKQHLIA 4350

  Fly  4315 MGRVEDRSPYIIVAFQECERMNNLMTELKRSLNELDLGLKGELTISSVMEDLMVCLYMDQVPEQW 4379
            ||.....:   |...||.:||..::..::....:|.|.::|.:.:|..:.|.:..::..:||..:
  Fly  4351 MGATSSMN---IFLRQEIDRMQRIIILVRSIFKDLLLAVEGTIIMSENLRDALDNIFNARVPTVF 4412

  Fly  4380 TKLAY-PSMLGLQSWFSDLMLRLRELEGWVADFRMPSSIWLAGFFNPQSLLTAIMQQTARKNE-W 4442
            .:.:: .|.||.  ||::|:.|..:...|....| |...|::||||||..|||:.|:.||.:: |
  Fly  4413 KRGSWVSSSLGF--WFTELLERHTQFYNWCFGAR-PVVFWMSGFFNPQGFLTAMRQEVARAHQGW 4474

  Fly  4443 PLDRMCLNCDVTKKWKEELTTAPREGAYINGLFMEGARWDMKMGTIADAFLKELFPAMPVLYIKA 4507
            .||::.::.||.|...||....|:||.::.|||::||.||.:...:.:|..|.||..|||::|.|
  Fly  4475 ALDQVTMHNDVLKVGPEECKKPPKEGVFVYGLFVDGAGWDKRTSRLVEATNKVLFTLMPVIHIYA 4539

  Fly  4508 VTQDKQDIKNVYECPVY-KIRLRGPTFVWTFNLKSRERASKWTLAGVCLL 4556
            :.........:|.|||| ||......::....|:|.:....|||.||.||
  Fly  4540 IFSTAAKNSKLYTCPVYKKINRTDLNYICALWLQSNKHPDHWTLRGVALL 4589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kl-5	NP_001015499.4	DHC_N1	197..763	CDD:285571	131/668 (20%)
		DHC_N2	1368..1770	CDD:285579	126/413 (31%)
		P-loop_NTPase	1903..2132	CDD:304359	141/229 (62%)
		P-loop_NTPase	2217..2352	CDD:304359	51/134 (38%)
		P-loop_NTPase	2510..2783	CDD:304359	81/278 (29%)
		P-loop_NTPase	2860..3127	CDD:304359	102/271 (38%)
		MT	3140..3480	CDD:289543	95/350 (27%)
		AAA_9	3509..3722	CDD:289547	93/215 (43%)
		Dynein_heavy	3864..4549	CDD:281078	209/701 (30%)
kl-3	NP_001104482.3	DHC_N1	266..800	CDD:285571	123/627 (20%)
		DHC_N2	1378..1778	CDD:285579	126/409 (31%)
		P-loop_NTPase	1914..2145	CDD:304359	141/230 (61%)
		P-loop_NTPase	2229..2364	CDD:304359	51/134 (38%)
		P-loop_NTPase	2521..2790	CDD:304359	79/272 (29%)
		P-loop_NTPase	2889..3151	CDD:304359	99/261 (38%)
		MT	3164..3506	CDD:289543	92/345 (27%)
		AAA_9	3538..3754	CDD:289547	93/215 (43%)
		Dynein_heavy	3900..4582	CDD:281078	209/701 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450571
Domainoid	1	1.000	84	1.000	Domainoid score	I5259
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47047
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740