Protein Alignment X11L and apba1a

DIOPT Version :10

• Sequence 1: NP_001285376.1
• Gene: X11L / 252671
• FlyBaseID: FBgn0026313
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_001343372.1
• Gene: apba1a / 100003938
• ZFINID: ZDB-GENE-060526-175
• Length: 968
• Species: Danio rerio
• Alignment Length: 1154
• Identity: 378/1154 - (32%)
• Similarity: 526/1154 - (45%)
• Gaps: 299/1154 - (25%)

  Fly    90 GSGSYGSNAGRDSGSYYYQRPQLHQ--IRLGRSPGSQFETRDVLPQGLASPGSPTDVGKADGQCL 152
            |.||..||..|:.|:........||  .|..|..||...|...     .:...|.:.|.|:.|.:
Zfish    41 GDGSSRSNRSRNHGTENNHHQSQHQGAPRYRRCEGSNGGTNRT-----HAARRPEEEGDAEQQTI 100

  Fly   153 RDGEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITMG 217
            :       ..|....:.:.   :|.|.||..|:          |:.:...:|...|.:...
Zfish   101 Q-------QPIPRPAVTRY---RRQGDNEARLR----------AQQQRQRQRERQQRDAER---- 141

  Fly   218 GPRKRPPGFPQRVSPT-TSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSET 281
            ..:.|.....|.:||| |.:.......|:          :.|.:.|..|.....|....:..::.
Zfish   142 AEQHRLEQQQQLLSPTQTMLPTREPEEAE----------EDEGDGSSALARSASTESGFHNHTDR 196

  Fly   282 RK-----VLEEFFKANPEDEKRY-------TDYTTESGDDVASSQPQEYPATPMEQAYIGQRLAR 334
            .:     |||    |.||||..|       .:..|||.:   |.|....||
Zfish   197 AEGDAVMVLE----AEPEDENTYGIPLRPEAEEYTESAE---SEQQHGGPA-------------- 240

  Fly   335 IPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTL 399
                  |:..:.|.:.||..:.|...                     |:..|||.        ||
Zfish   241 ------YLQPQYPPQPPPLPREPLPN---------------------AERPLEAE--------TL 270

  Fly   400 SPETTDYDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASDT--ENNVSVVCDK---- 458
            :|   :|.|.........|    ||:.|:.:......::..|..:...|  |:....:.|.
Zfish   271 NP---NYSSYVYTQPMYHN----PTEAGEAHEGGATEDEQYSEPYVDYTLQEHVYEEITDAPLSR 328

  Fly   459 ---QQSSQSQP---------VHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPP 511
               |...|.:|         ..:....|.||.: |:..|..    .:|:.:..  ::||  |.|.
Zfish   329 AEGQTPQQQRPEFRLFERDLYQQQEAVGSRLHH-YDERSDG----ESDSPEKE--AEFA--PYPR 384

  Fly   512 APPPSSPPQIE--IADASES----------MTMVPDADNPLD-----SHYGAVYAAALGGTHTEK 559
            |........|:  :|:..||          |.:..|.|...|     ||          |...:.
Zfish   385 ADSCEQDEDIDQIVAEVKESLSSQSLDRIAMGLNKDGDKEEDWPESESH----------GQLNDN 439

  Fly   560 SAGSGLGVTPVTAGGSLPSQAASE--------------IQEAMKEIRSALQRAKTQPEKLKFCDE 610
            :.     :.||:. |.||...:.:              |..|:|:|:.|::..||:..:..:
Zfish   440 NP-----LEPVSE-GELPRSPSEDQAPVIRSSREKRDAISLAIKDIKEAIEEVKTRTVRSPY--- 495

  Fly   611 VLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEG 675
             .|.:|..|:||.|:            |..|..:.:....||          ||...:.:.:.:|
Zfish   496 -TPDEPKEPIWVMRQ------------DLSPTAESDLQPSLG----------ADSPGSGSTSPQG 537

  Fly   676 TDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEK 740
            .:.:|:..::....::..:|....|....|.|:.            |...::.|..|
Zfish   538 AESSSHQMMSQEGSDSFESPSPAGKESRRSLASF------------PTYVEVPGPCD-------- 582

  Fly   741 LQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVCEGQPTKSTR 805
                                              |:.||:|::|.|.|||||||:.:..|:|:.|
Zfish   583 ----------------------------------PEDLIDGIIFAANYLGSTQLLSDKTPSKNVR 613

  Fly   806 MMQAEEAVSRIKAL---------APEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISY 861
            ||||:|||||||..         ||||::||.|||||||||::|.|||.|.:|.||||.||||||
Zfish   614 MMQAQEAVSRIKTAQKLAKNKKKAPEGDAQPMTEVDLFISTQRIKVLNADSQETMMDHPLRTISY 678

  Fly   862 IADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFES 926
            |||||::||||||||.            |..|      .:|.....:|.....|..|||||||||
Zfish   679 IADIGNIVVLMARRRM------------PRSD------SQENMEASDPAQDEKRQYKMICHVFES 725

  Fly   927 DEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVV 991
            ::||.|||||||||.|||.|||:||||..|.|::: :|.::||:|:::.|:|..|:|.|..|:|.
Zfish   726 EDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQK-EYSDLLNTQDMYNDDLIHFSKSENCKDVY 789

  Fly   992 VPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQ 1056
            :.|.||||||:|||||||||:||||:|||:|..|.|.:.|:||||||:::|||.|||||||||||
Zfish   790 IEKQKGEILGLVIVESGWGSILPTVIIANMMHGGPAEKSGRLNIGDQIMSINGTSLVGLPLSTCQ 854

  Fly  1057 SYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRI 1121
            |.|:..|||:.:|..:|.||||..|.|.||...:|||||||||:||||:||||||||||||||||
Zfish   855 SIIKGLKNQSRIKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRI 919

  Fly  1122 IEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170
            ||||:|||||.||:.||.:||::||||.|||||.:|:||||.||.|:||
Zfish   920 IEINSQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	105/187 (56%)
		PDZ1_APBA1_3-like	988..1071	CDD:467203	55/82 (67%)
		PDZ2_APBA1_3-like	1082..1154	CDD:467255	54/71 (76%)
apba1a	XP_001343372.1	Mint1_CID	469..514	CDD:439308	14/60 (23%)
		PTB_X11	583..754	CDD:269919	106/188 (56%)
		PDZ1_APBA1_3-like	786..871	CDD:467203	55/84 (65%)
		PDZ2_APBA1_3-like	875..952	CDD:467255	57/76 (75%)