Protein Alignment FUS and fus

DIOPT Version :10

• Sequence 1: NP_004951.1
• Gene: FUS / 2521
• HGNCID: 4010
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_957377.3
• Gene: fus / 394058
• ZFINID: ZDB-GENE-040426-1010
• Length: 542
• Species: Danio rerio
• Alignment Length: 578
• Identity: 360/578 - (62%)
• Similarity: 402/578 - (69%)
• Gaps: 88/578 - (15%)

Human     1 MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSG--YGQSSYSS-YGQSQ 62
            ||||||.|.::..||.|..|.||.|||.|:|.|.||||.||:||:::|.  |.|..||| |||||
Zfish     1 MASNDYGQTSSHGYGGYGGQSGQSYSQPSAQNYSQQSYGGYNQSSESSSAPYNQGGYSSNYGQSQ 65

Human    63 NTGYGTQSTPQGYG------STGGYGSSQ----SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSS 117
            :.|||:|:..|||.      |:|||.::.    :....|.|||||.||.|. :|:|..|.|.|||
Zfish    66 SGGYGSQAPSQGYSQSSQSYSSGGYSNTSQPPPAQSGGYSQQSSYSGYNQS-SPASAPGGYSSSS 129

Human   118 QSSSYGQPQ-------SGSYSQQPSY-------------GGQQQ-------SYGQQQSYN--PPQ 153
            |||.|||.|       .||..|...|             |||.|       ||....:|:  |||
Zfish   130 QSSGYGQQQQQSGGGYGGSGGQSGGYGSSGGQSSGFGGSGGQHQSSQSGGGSYSPSPNYSSPPPQ 194

Human   154 GYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGR 218
            .||||:||           |.|.|.||...| ||||.|||||.||       |||.|..||||||
Zfish   195 SYGQQSQY-----------GQGGYNQDSPPM-SGGGGGGGYGGQD-------GGYSQDGRGGRGR 240

Human   219 GGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGS--RHDSEQDN 281
            |  ||.||.|.||::|.       ||||.| ||||||..|||||||||||||.|:  .:..||||
Zfish   241 G--GGFGGRGAGGFDRG-------GRGGPR-GRGGMGMGDRGGFNKFGGPRDHGAGGPNMQEQDN 295

Human   282 SDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPS 346
            ||||||||||||::.|::|||||||||||||.|||||.|||||||||||||||||||||||||||
Zfish   296 SDNNTIFVQGLGDDYTVDSVADYFKQIGIIKVNKKTGLPMINLYTDRETGKLKGEATVSFDDPPS 360

Human   347 AKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNG--RGGRGRGGPMGRGGYGGGGSGGGGRGG 409
            |||||||||||:|:|||||||||||||:|.|||.:|  ||||||||||||||:|||..|||| ||
Zfish   361 AKAAIDWFDGKDFNGNPIKVSFATRRAEFGRGGSSGGMRGGRGRGGPMGRGGFGGGRGGGGG-GG 424

Human   410 FP--SGGGG----GGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNY 468
            |.  :||||    ||||||||||||.||:|.|:||||||||||||.|||:|.|||.  |.|||.:
Zfish   425 FQGNNGGGGGSGNGGGQQRAGDWKCSNPSCGNLNFSWRNECNQCKEPKPEGSGGGM--SPMGGGF 487

Human   469 GDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY 526
            |.:|  ||||:||||:|||||||||||||| ||||||||||||||||:||.|||:|||
Zfish   488 GGER--GRGGFDRGGFRGRGGDRGGFRGGR-GGDRGGFGPGKMDSRGDHRHDRRDRPY 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..286		160/328 (49%)
		RRM_FUS_TAF15	283..368	CDD:409951	75/84 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..424		39/56 (70%)
		zf-RanBP	422..449	CDD:395516	22/26 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..526		62/81 (77%)
fus	NP_957377.3	None