Protein Alignment FUS and caz

DIOPT Version :10

• Sequence 1: NP_004951.1
• Gene: FUS / 2521
• HGNCID: 4010
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_523365.2
• Gene: caz / 32587
• FlyBaseID: FBgn0285954
• Length: 399
• Species: Drosophila melanogaster
• Alignment Length: 461
• Identity: 195/461 - (42%)
• Similarity: 235/461 - (50%)
• Gaps: 110/461 - (23%)

Human   111 GSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYN-PPQGYGQQNQYNSSSGGGGGGGGG 174
            |.||..|     ||..:......|:|   ||...:..:|| ||..||:|        |||...|.
  Fly     4 GGYGGGS-----GQGYNNFAVPPPNY---QQMPNKTGNYNEPPPNYGKQ--------GGGYDSGS 52

Human   175 GNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGY 239
            |:.|      |.|.|:||        |||||    ..|||    |.|.|.||.....||:..|||
  Fly    53 GHRG------SGGSGNGG--------GGGGS----WNDRG----GNSYGNGGASKDSYNKGHGGY 95

Human   240 EPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADY 304
            ...|.|||.||.||.||:|.                     .:..:||||.|:..:.|.:.:..:
  Fly    96 SGGGGGGGGGGGGGSGGNDM---------------------ITQEDTIFVSGMDPSTTEQDIETH 139

Human   305 FKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFA 369
            |..|||||.:|:|.:|.|.||.::|||..||||||::||..:|::||:||||::|:||.||||.|
  Fly   140 FGAIGIIKKDKRTMKPKIWLYKNKETGASKGEATVTYDDTNAAQSAIEWFDGRDFNGNAIKVSLA 204

Human   370 TRRADFNRGGGNGRGGRGRGGPMG-RGGYGGGGSGGGGRGGFPSGGGGGGG-------------- 419
            .|:.::|:|||.|.||.||||..| |||.||||.||||.|.|..|||||||
  Fly   205 QRQNNWNKGGGGGGGGGGRGGFGGRRGGGGGGGGGGGGGGRFDRGGGGGGGRYDRGGGGGGGGGG 269

Human   420 ---QQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDR 481
               |.|.|||||  .:|.|.||:||||||:||.||.|..|...||.  ||.||..  ||.|||||
  Fly   270 GNVQPRDGDWKC--NSCNNTNFAWRNECNRCKTPKGDDEGSSGGGG--GGGYGGG--GGGGGYDR 328

Human   482 GGYRGRGG------DRGG-FRGGRGGG----------DRGGFGPGKMDSRGEHRQD--------- 520
            |..||.||      |||| .:||.|||          |..|.|.|.....|.:|:|
  Fly   329 GNDRGSGGGGYHNRDRGGNSQGGGGGGGGGGGYSRFNDNNGGGRGGRGGGGGNRRDGGPMRNDGG 393

Human   521 RRERPY 526
            .|.|||
  Fly   394 MRSRPY 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..286		57/175 (33%)
		RRM_FUS_TAF15	283..368	CDD:409951	42/84 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..424		34/66 (52%)
		zf-RanBP	422..449	CDD:395516	17/26 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..526		44/107 (41%)
caz	NP_523365.2	RRM_SARFH	122..204	CDD:240978	42/81 (52%)
		zf-RanBP	275..304	CDD:395516	20/30 (67%)
		RanBP2-type Zn finger	279..298	CDD:275375	13/20 (65%)