Protein Alignment FUS and fust-1

DIOPT Version :10

• Sequence 1: NP_004951.1
• Gene: FUS / 2521
• HGNCID: 4010
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_495483.1
• Gene: fust-1 / 174175
• WormBaseID: WBGene00016173
• Length: 448
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 184/513 - (35%)
• Similarity: 221/513 - (43%)
• Gaps: 166/513 - (32%)

Human    56 SSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSS 120
            ::|.|||    ...|||:|                   |.:|..|.||            ..|..
 Worm     2 AAYDQSQ----PDYSTPEG-------------------QQAYWAYYQQ------------QQQQQ 31

Human   121 SYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPP----QGYGQQNQYNSSSGGGGGGGGGGNYGQDQ 181
            ..|||....|: ..:|||..|:...|..|.||    ..|||        |.||..||...|||
 Worm    32 PGGQPDQDPYA-AAAYGGHDQAQQPQNPYAPPPPGADPYGQ--------GSGGQSGGSDPYGQ-- 85

Human   182 SSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGG 246
               |.|||.||..|::   ||||..|         |||||.||..||.|||....|     ||||
 Worm    86 ---SRGGGRGGFGGSR---GGGGYDG---------GRGGSRGGYDGGRGGYGGDRG-----GRGG 130

Human   247 GRGGRGG--MGGS--DRGGFNKFGGP-------RDQGSRHD----------------SEQDNSD- 283
            ||||..|  .|||  |.|..::.|||       :|:|.|.|                :.:..||
 Worm   131 GRGGYDGERRGGSRWDDGNSDRQGGPPGGRGGYQDRGPRRDGPPSGGGYGGGGAASGNREFGSDG 195

Human   284 ----NNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDP 344
                ..|:||||:........:||.|...|.|..|.:  .|.|.:||||.||:.|||..::|.|.
 Worm   196 RVELKETVFVQGISTTANEAYIADVFSTCGDIAKNDR--GPRIKIYTDRNTGEPKGECMITFVDA 258

Human   345 PSAKAAIDWFDGKEFSG--NPIKVSFATRRADF--NRGGGNGRG--GRGRGGPM-GRGGYG---G 399
            .:|:.||..::|:.|.|  :|:.:|.|..|||.  .|||..|||  |.|||||| ||||:|   |
 Worm   259 SAAQQAITMYNGQPFPGGSSPMSISLAKFRADAGGERGGRGGRGGFGGGRGGPMGGRGGFGGDRG 323

Human   400 GGSGGGGRGGFPSGGGGGGG--------------------------------------------- 419
            |..||||||||..|.|||||
 Worm   324 GYGGGGGRGGFDGGRGGGGGFRGGDRGGFRGGDRGGFRGGDRGGFRGGDRGGDRGGFRGGRGVGG 388

Human   420 -----QQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDR 472
                 :||..||.|..  |.|.||::|.|||||:||:|||..||.||...||..|.||
 Worm   389 GNANMEQRKNDWPCEQ--CGNSNFAFRRECNQCQAPRPDGGSGGGGGERRGGPPGGDR 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..286		85/265 (32%)
		RRM_FUS_TAF15	283..368	CDD:409951	32/91 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..424		36/106 (34%)
		zf-RanBP	422..449	CDD:395516	14/26 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..526		18/29 (62%)
fust-1	NP_495483.1	RRM_FET	203..284	CDD:409722	30/82 (37%)
		ZnF_RBZ	398..421	CDD:197784	13/24 (54%)