Protein Alignment FUS and fus

DIOPT Version :8

• Sequence 1: NP_004951.1
• Gene: FUS / 2521
• HGNCID: 4010
• Length: 526
• Species: Homo sapiens
• Sequence 2: XP_012809196.1
• Gene: fus / 100038234
• XenbaseID: XB-GENE-495119
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 586
• Identity: 411/587 (70%)
• Similarity: 441/587 (75%)
• Gaps: 92/587 (16%)

Human     1 MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSY-SSYGQSQNT 64
            ||:|||:|||:|.|||||:||.|||.||.||.|.||.||||.||...|.||||.| |||||.|:.
 Frog     1 MATNDYSQQASQGYGAYPSQPSQGYGQQGSQSYSQQGYSGYGQSAGGSSYGQSGYSSSYGQDQSA 65

Human    65 GYGTQSTPQGYGSTGGYGSSQSSQSSYG-------QQSSYPGYGQQPAPSSTSGSYGSSSQSSSY 122
            ||.:||||||||| ||||:||||||.||       .||||..|.|||..||.:|||..|||.|||
 Frog    66 GYSSQSTPQGYGS-GGYGNSQSSQSPYGSGQPQQQSQSSYSSYSQQPPASSNTGSYSGSSQPSSY 129

Human   123 GQPQSGSYSQQP---------SYGGQQQ------------------SYGQQQ--SYNPPQGYG-Q 157
            .|.|||.|.|||         |||||||                  ||||||  ||:.||||| |
 Frog   130 QQQQSGGYGQQPSGGYGSQQSSYGGQQQSSYGSQQGQSGYGSQQPSSYGQQQQSSYSQPQGYGQQ 194

Human   158 QNQYNSSSGGGGGGGG---------GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR 213
            |.||:         ||         .|.|.||..||.|     |.||     ||...||||.|||
 Frog   195 QTQYS---------GGVPDVYDLFPAGGYNQDSPSMGS-----GSYG-----GGSDQGGYGGQDR 240

Human   214 GGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGS--RHD 276
             ||||||.||.|||||||    :||::.||| |.|||||||||.:||||:||||||:.|.  ||:
 Frog   241 -GRGRGGFGGRGGGGGGG----AGGFDSRGR-GSRGGRGGMGGGERGGFSKFGGPREGGGPPRHE 299

Human   277 -SEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVS 340
             :||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
 Frog   300 MAEQDNSDNNTIFVQGLGENVTVESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVS 364

Human   341 FDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFN-RGGGNGRG-GRGRGGPMGRGGYGG--GG 401
            |||||||||||||||||||||||||||||||||||| |||||||| ||| ||||||||:||  ||
 Frog   365 FDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNSRGGGNGRGRGRG-GGPMGRGGFGGPPGG 428

Human   402 SGG-GGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMG 465
            ||. ||.||:||   ||||||||||||||||:||||||||||||||||||||:|| |||||||||
 Frog   429 SGSRGGSGGYPS---GGGGQQRAGDWKCPNPSCENMNFSWRNECNQCKAPKPEGP-GGPGGSHMG 489

Human   466 GN-----YGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERP 525
            |:     :||:|||||||:||||:|||||||||||||| ||||||||||||||||:||||||:||
 Frog   490 GDVIAGGFGDERRGGRGGFDRGGFRGRGGDRGGFRGGR-GGDRGGFGPGKMDSRGDHRQDRRDRP 553

Human   526 Y 526
            |
 Frog   554 Y 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUS	NP_004951.1	RRM_FUS_TAF15	283..368	CDD:240979	84/85 (99%)
		zf-RanBP	422..449	CDD:279035	26/27 (96%)
fus	XP_012809196.1	RRM	<298..>398	CDD:223796	96/100 (96%)
		RRM_FUS_TAF15	307..392	CDD:240979	84/85 (99%)
		zf-RanBP	447..474	CDD:279035	26/27 (96%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C309027512
eggNOG	1	0.900				E1_KOG1995
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	761	1.000	Inparanoid score	I4357
OMA	1	1.010
OrthoDB	1	1.010				D1539664at2759
OrthoFinder	1	1.000				FOG0002470
OrthoInspector	1	1.000				T1889081
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R4499
TreeFam	1	0.960
	10	9.890