Protein Alignment Gclm and AKR1D1

DIOPT Version :10

• Sequence 1: NP_732780.1
• Gene: Gclm / 248194
• FlyBaseID: FBgn0046114
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_005980.1
• Gene: AKR1D1 / 6718
• HGNCID: 388
• Length: 326
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 48/225 - (21%)
• Similarity: 79/225 - (35%)
• Gaps: 56/225 - (24%)

  Fly    20 IATELGQRKSNEELYDGLKITLHTDSTAERVVVEKEIDELHGRVQRATQELTTRLTENGRNEISI 84
            :|.:.|.|.     .||..|..:.....|  .:.::|.|  |:|:              |.:|..
Human    43 VAIDTGYRH-----IDGAYIYQNEHEVGE--AIREKIAE--GKVR--------------REDIFY 84

  Fly    85 GAKIFLNRHSTESVNQAVEELLHILSVTHVD----NVVLAYHPNAVATATPVATTKPPCSEDSNV 145
            ..|::...|..|.|...:|..|.:|.:.:||    .|.:|:.|.                 |...
Human    85 CGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPG-----------------DEIY 132

  Fly   146 SRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHNSAQV--VPTIAQV 208
            .|..|......|..:....|..:..:...|   :..||:::.:...||.:.|...:  .|...||
Human   133 PRDENGKWLYHKSNLCATWEAMEACKDAGL---VKSLGVSNFNRRQLELILNKPGLKHKPVSNQV 194

  Fly   209 NLSTCC---VVPPELQEFCTAHDIQLNTHS 235
            .    |   ...|:|.:||..|||.:..:|
Human   195 E----CHPYFTQPKLLKFCQQHDIVITAYS 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gclm	NP_732780.1	AKR_SF	<79..>235	CDD:444925	36/164 (22%)
AKR1D1	NP_005980.1	AKR_AKR1D1-3	15..322	CDD:381335	48/225 (21%)