DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tcp1 and CCT1

DIOPT Version :9

Sequence 1:	NP_036802.1	Gene:	Tcp1 / 24818	RGDID:	3832	Length:	556	Species:	Rattus norvegicus
Sequence 2:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	406/555 - (73%)
Similarity:	475/555 - (85%)	Gaps:	2/555 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLL 65
            :..|||:.|.|.:|.::|:||||||.||:||||||||||||||||||||||||:||||||||:||
  Fly     4 LASPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLL 68

  Rat    66 EVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVR 130
            ||||||||||.|||.|||:|||||||||||:||||||||||||||||||||:|||||:|||||.:
  Fly    69 EVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACK 133

  Rat   131 YINENLIINTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAVKYTDIRGQPRYPVNSV 195
            ||:|:|....||||||.|||.|||||||||||.:.:||:.|||||..:||.||.|||..|.:.::
  Fly   134 YISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAI 198

  Rat   196 NILKAHGRSQIESMLINGYALNCVVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKL 260
            |:|||||:|..||:||.||||||.:.||.|.|:|||||||||||||||||||:||||:|.||:||
  Fly   199 NVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKL 263

  Rat   261 DQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGA 325
            :.||.||.|||||||..||.||.||:|.:||:||:|:||||||||||||||.|.|||.||||:||
  Fly   264 EAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGA 328

  Rat   326 SILSTLANLEGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMER 390
            :.:::|.|::|||:|:|:|:|:|.||.|||||||||||||.||||.:|||||||.|||.||||||
  Fly   329 AFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMER 393

  Rat   391 SLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVN 455
            |:||||||||||||||.||.|||.|||||||||||:|||:.|||||||||||:||||||.||:||
  Fly   394 SVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVN 458

  Rat   456 AAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEA 520
            ||:|:||||||||::||.:|..|||.:|||.||||:.|..||||:|||.||.:.|:|||||||||
  Fly   459 AAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEA 523

  Rat   521 AITILRIDDLIKLHPESKDDKHGGYENAVHSGALD 555
            |||||||||:|||:||.|..|  .|.:|..:|.||
  Fly   524 AITILRIDDMIKLNPEDKSGK--SYADACAAGELD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tcp1	NP_036802.1	TCP1_alpha	9..535	CDD:239451	394/525 (75%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	394/525 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335373
Domainoid	1	1.000	757	1.000	Domainoid score	I87
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5656
Inparanoid	1	1.050	796	1.000	Inparanoid score	I483
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	1	1.000	-	-		FOG0005251
OrthoInspector	1	1.000	-	-		oto98218
orthoMCL	1	0.900	-	-		OOG6_101890
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3773
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770