DRSC/TRiP Functional Genomics Resources

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Protein Alignment cGlr2 and Cgas

DIOPT Version :10

Sequence 1:NP_001400984.1 Gene:cGlr2 / 246606 FlyBaseID:FBgn0050424 Length:459 Species:Drosophila melanogaster
Sequence 2:NP_775562.2 Gene:Cgas / 214763 MGIID:2442261 Length:507 Species:Mus musculus


Alignment Length:394 Identity:89/394 - (22%)
Similarity:150/394 - (38%) Gaps:117/394 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SRNLENFVEKKLYECKKKYVDIPKDEGQRYGKHYEALTSKIFEILRKENPELDIIIAEFSLEGSV 68
            ||...:.::|.|.:.:.|..|| .:..:...|..|.|      :.|.:..|.:....|....||.
Mouse   143 SRKEPDKLKKVLDKLRLKRKDI-SEAAETVNKVVERL------LRRMQKRESEFKGVEQLNTGSY 200

  Fly    69 GDMLKIAKPNEFDLVFKLKFP------YYKSIA--VTRDPKIP-GNVL--------LDMTRVLEL 116
            .:.:||:.|||||::|||:.|      ||::.|  :.:..:|| ||.|        |..|::|..
Mouse   201 YEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSK 265

  Fly   117 LKDDPREDFQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRT 181
            .:...:|:.:.|::              :|                           ||..|.:.
Mouse   266 FRKIIKEEVKEIKD--------------ID---------------------------VSVEKEKP 289

  Fly   182 CGPAHTIYVYGDYEYSVDYVPAICLAAE---------------QNVLPTKQLECFKRANTSYWEA 231
            ..||.|:.:....|.|||    |.||.|               |..|.||.....:|   ..:..
Mouse   290 GSPAVTLLIRNPEEISVD----IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRR---EPFYL 347

  Fly   232 IPKPLKPLTETSMISFRSSFYAVEKILLQD--VHENC----------RNAIRFM--------KKF 276
            :||..|........::|.||...||.:|.:  :.:.|          :..::.|        |:|
Mouse   348 VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEF 412

  Fly   277 RDVKTNLGNCKSYYIKTLFLWKIIQEPESYWLNPLSFILADMFDDL----AENLRRGVITFFWDP 337
            :::.   ..| ||::||.......|:|:....:|.:  |:..||.|    .|.||...:..::.|
Mouse   413 QELD---AFC-SYHVKTAIFHMWTQDPQDSQWDPRN--LSSCFDKLLAFFLECLRTEKLDHYFIP 471

  Fly   338 ELNM 341
            :.|:
Mouse   472 KFNL 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cGlr2NP_001400984.1 Mab-21 69..261 CDD:460873 53/223 (24%)
Mab-21_C 265..359 CDD:466416 21/99 (21%)
CgasNP_775562.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..151 2/7 (29%)
DNA-binding. /evidence=ECO:0000269|PubMed:28363908 1..146 2/2 (100%)
PHA03247 <3..142 CDD:223021
Required for association with the cell membrane. /evidence=ECO:0000250|UniProtKB:Q8N884 48..59
Required for activation upon DNA viral infection. /evidence=ECO:0000269|PubMed:28314590 119..132
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q8N884 154..159 1/4 (25%)
DNA-binding. /evidence=ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0007744|PDB:5N6I 158..201 11/49 (22%)
Mab-21 200..377 CDD:460873 53/224 (24%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q8N884 281..291 4/36 (11%)
Interaction with collided ribosomes. /evidence=ECO:0000250|UniProtKB:Q8N884 329..370 11/43 (26%)
DNA-binding. /evidence=ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0007744|PDB:5N6I 372..395 3/22 (14%)
Mab-21_C 393..495 CDD:466416 20/89 (22%)
Blue background indicates that the domain is not in the aligned region.

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