DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30424 and Cgas

DIOPT Version :9

Sequence 1:	NP_001097455.1	Gene:	CG30424 / 246606	FlyBaseID:	FBgn0050424	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_775562.2	Gene:	Cgas / 214763	MGIID:	2442261	Length:	507	Species:	Mus musculus

Alignment Length:	326	Identity:	74/326 - (22%)
Similarity:	124/326 - (38%)	Gaps:	110/326 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKIAKPNEFDLVFKLKFP------YYKSIA--VTRDPKIP-GNVL--------LDMTRVLELLKD 49
            :||:.|||||::|||:.|      ||::.|  :.:..:|| ||.|        |..|::|...:.
Mouse   204 VKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRK 268

  Fly    50 DPREDFQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRTCGP 114
            ..:|:.:.|::              :|                           ||..|.:...|
Mouse   269 IIKEEVKEIKD--------------ID---------------------------VSVEKEKPGSP 292

  Fly   115 AHTIYVYGDYEYSVDYVPAICLAAE---------------QNVLPTKQLECFKRANTSYWEAIPK 164
            |.|:.:....|.|||    |.||.|               |..|.||.....:|   ..:..:||
Mouse   293 AVTLLIRNPEEISVD----IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRR---EPFYLVPK 350

  Fly   165 PLKPLTETSMISFRSSFYAVEKILLQD--VHENC----------RNAIRFM--------KKFRDV 209
            ..|........::|.||...||.:|.:  :.:.|          :..::.|        |:|:::
Mouse   351 NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQEL 415

  Fly   210 KTNLGNCKSYYIKTLFLWKIIQEPESYWLNPLSFILADMFDDL----AENLRRGVITFFWDPELN 270
            .   ..| ||::||.......|:|:....:|.:  |:..||.|    .|.||...:..::.|:.|
Mouse   416 D---AFC-SYHVKTAIFHMWTQDPQDSQWDPRN--LSSCFDKLLAFFLECLRTEKLDHYFIPKFN 474

  Fly   271 M 271
            :
Mouse   475 L 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30424	NP_001097455.1	Mab-21	1..289	CDD:281298	74/326 (23%)
Cgas	NP_775562.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151
		DNA-binding. /evidence=ECO:0000269\|PubMed:28363908	1..146
		PHA03247	<3..142	CDD:223021
		Required for association with the cell membrane. /evidence=ECO:0000250\|UniProtKB:Q8N884	48..59
		Required for activation upon DNA viral infection. /evidence=ECO:0000269\|PubMed:28314590	119..132
		DNA-binding. /evidence=ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0007744\|PDB:5N6I	158..201
		Mab-21	200..495	CDD:397398	74/326 (23%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8N884	281..291		4/36 (11%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:23647843, ECO:0000269\|PubMed:28902841, ECO:0000269\|PubMed:28963528, ECO:0007744\|PDB:5N6I	372..395		3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030