DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-3 and brdt

DIOPT Version :9

Sequence 1:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	XP_002662470.2	Gene:	brdt / 333996	ZFINID:	ZDB-GENE-030131-5928	Length:	1093	Species:	Danio rerio

Alignment Length:	325	Identity:	95/325 - (29%)
Similarity:	141/325 - (43%)	Gaps:	72/325 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRLNTGCYLSA 75
            |..:..|..|:|.:||..:...||.||:|:|.:.|||.|||||:.:|||:||::.::....|..|
Zfish   270 SERLKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDA 334

  Fly    76 ADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQV-----QLYICSSGSKV---RAEE 132
            ..||.|:||:|.|.|.|..|.|....||::||.:||..:|::     .....||.::|   ||..
Zfish   335 LQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKIPDEPKNANPVSSHNRVKKERARS 399

  Fly   133 ESSSDESD--SSSPE-----DEVNGSEVSPSIMGAPPSCTPTTE----CTPTPDWTP-------- 178
            .|||:.||  |||||     :|.:..|.:..:...........|    .|.||...|
Zfish   400 PSSSESSDSESSSPENSSDTEEEDEEERAHRLASLEEQLKAVREQLQLLTQTPLLKPKKKEKSKK 464

  Fly   179 ------------------PATL-------ETSEQQE-------------PFTTEEDLDLHAKIQQ 205
                              ||.:       ::|.::|             |.:.||...|...|.:
Zfish   465 KKKKERESSKRKGEEMKKPAKILKRSSSSKSSGRKESRACDSEEEMNTLPMSYEEKRQLSLDINK 529

  Fly   206 LDGEVLLHVIHFIQRMEG--AEYCNKELEFDICKLKVHTKRGIRDYLASKGFTGKRVART---KP 265
            |.|:.|..|::.|:..|.  .:...:|:|.|...||..|.|.:..|:.  |...|:...|   ||
Zfish   530 LPGDKLGKVVNIIKAREPLLRDTDPEEIEIDFETLKPSTLRALECYVV--GCLRKKTKETNKNKP 592

Fly 266 265
Zfish 593 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	43/100 (43%)
brdt	XP_002662470.2	Bromo_Brdt_I_like	29..135	CDD:99929
		Bromo_Brdt_II_like	273..373	CDD:99930	43/99 (43%)
		BET	514..577	CDD:293640	19/62 (31%)
		BRD4_CDT	1050..1093	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.940