DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30340 and PRLHR

DIOPT Version :9

Sequence 1:	NP_724812.2	Gene:	CG30340 / 246550	FlyBaseID:	FBgn0050340	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_004239.2	Gene:	PRLHR / 2834	HGNCID:	4464	Length:	370	Species:	Homo sapiens

Alignment Length:	332	Identity:	88/332 - (26%)
Similarity:	148/332 - (44%)	Gaps:	64/332 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LHKPNGEITWKICTFLPLIAFGLYGNFSMVYVIATNRSLRSPTNLIIANMAVADLLTLAICPAMF 88
            :|:..|.|   :..:..::..||.||..:|.|||..|.|.:.||.:|.|:|::|:|....|..:.
Human    56 VHQLKGLI---VLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLT 117

  Fly    89 MVNDFY-QNYQLGCVGCKLEGFLVVVFLITAVLNLSVVSYDRLTAIVLPMETRLTIRGVQIVVVC 152
            :...|. :.:..|...|.|..||..|.:..:|..|:.::.||...:|.|:..|:::|.....|:.
Human   118 LAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLA 182

  Fly   153 TWVSGILLASPLAFYRSYRVRVWKNFTERYCKENTSVLPKYW-------------YVLITILVWL 204
            .|....:||.|.|.: :|.|.: |....|.|:|       :|             .:|:|.|  |
Human   183 IWALSAVLALPAAVH-TYHVEL-KPHDVRLCEE-------FWGSQERQRQLYAWGLLLVTYL--L 236

  Fly   205 PLGIMLICYIAIFYKLDRYEKRVLSRENPLTVSY---------KRSVAKTLFIVVVVFAALRLPF 260
            ||.::|:.|:.:..||   ..||:    |..|:.         :|.....|.::|||||...||.
Human   237 PLLVILLSYVRVSVKL---RNRVV----PGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPL 294

  Fly   261 TILVVLR-------EKY-FGEDVSVSSGMQLFWYISQYLMFLNAAVNPLIYGFNNENFRRAYYQ- 316
            .:..:||       :.| ||          |...:..:|...:|..||.||.:.:::||....:
Human   295 HVFNLLRDLDPHAIDPYAFG----------LVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKL 349

  Fly   317 -ISWVRR 322
             ::|.|:
Human   350 LVAWPRK 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30340	NP_724812.2	7tm_4	44..315	CDD:304433	83/301 (28%)
CG30340	NP_724812.2	7tm_1	48..303	CDD:278431	77/285 (27%)
PRLHR	NP_004239.2	7tmA_PrRP_R	77..346	CDD:320516	81/296 (27%)
		TM helix 2	95..120	CDD:320516	8/24 (33%)
		TM helix 3	134..164	CDD:320516	9/29 (31%)
		TM helix 4	175..196	CDD:320516	5/20 (25%)
		TM helix 5	222..251	CDD:320516	8/30 (27%)
		TM helix 6	271..301	CDD:320516	9/29 (31%)
		TM helix 7	314..339	CDD:320516	8/34 (24%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000269\|PubMed:11641419	365..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100