Protein Alignment CG30275 and CFAP61

DIOPT Version :10

• Sequence 1: NP_788430.3
• Gene: CG30275 / 246522
• FlyBaseID: FBgn0050275
• Length: 1298
• Species: Drosophila melanogaster
• Sequence 2: NP_056400.3
• Gene: CFAP61 / 26074
• HGNCID: 15872
• Length: 1237
• Species: Homo sapiens
• Alignment Length: 1291
• Identity: 282/1291 - (21%)
• Similarity: 519/1291 - (40%)
• Gaps: 220/1291 - (17%)

  Fly     7 RLAQAGDQDGLNKLIRSPGVKWFGNIRPKFRGKDSLFNSYQTYRILAFCTESSALVAYAEFRNYP 71
            |..::.|...:..|||....|.||.:       :.::...:....:..|.:...::|.|.|.:||
Human    17 RRTESQDVYCIKSLIRKFTCKLFGKL-------NIIYLLEKANLAVTLCNDKEEIMAQATFLDYP 74

  Fly    72 SIAALPTDCWLEWLSTRYCLSMSI--SWLNALFFNFCVYKSDQS-PVLVEIIKDVLYRESRVWFL 133
            :......|   :|:|....|...|  :.||.||.:..|...:.| ....||::.|......:.|:
Human    75 NWNVAKQD---DWVSVFRELDSDIPCTPLNTLFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFI 136

  Fly   134 ITVRCPYVPQPIHFVETFDDLEKISQVFYPLEYSMDKNNNTQSLYIVDRFVILPRITYRKALAED 198
            ..:...|:......:..||.:..|..:.|..::         :::|..|....|::..|||..||
Human   137 FLIVPSYMSLGSTLITVFDQVGNIPCLTYEEDF---------AVHICHRHSHYPQLHVRKARVED 192

  Fly   199 NDDIIAMQEVENPEMREELGDYYIAEEVMGQNPKSMLVVAETINQSQESEMAIFLWLSSDIDIMF 263
            :||::.:....:..::|..|:|::||.:..|:.::..||.|.     |.....|:.:.|.:::..
Human   193 HDDLMPIFMRYDTILKETYGEYFLAELIEAQDEENHAVVCEV-----EGTAVGFMSVCSRVNMQL 252

  Fly   264 YVRNYEMEQFGNLVKPADGRSFHYETMTVS----SVQRRAEASMFTADALDDLNAVTILGGLQKV 324
            ....:::..|..|..|      |.:.:..|    ||:|..:|.:.::..           |.||:
Human   253 LHECFDLGPFHGLCFP------HPDDVLESPQDLSVRRSQDAELRSSSQ-----------GSQKI 300

  Fly   325 DSGMSVASLGKMKVSSIGGTIVDTNVANENKFYMRECLYSKFKYILEKLH--STDYYLRH---EQ 384
            ...:. ..:....:.:|.|.|.....:.|....::....|:.:.| |||.  ||.|...|   .:
Human   301 VEELQ-EPVSPDTMENIQGNIAREAASEEALTAVQSGNVSEPEDI-EKLSDISTGYAQYHHVSSR 363

  Fly   385 SVINFIYPAGTEPAGPAAM---AAASNVFLLRCIVARQDFPLPRLFNAMVAIFSAYPDRDYCMML 446
            |:.:.:.|  .||.....:   |:|:....|.||..:.:   .|..:.|..:||.:.|:::|  :
Human   364 SLASLVLP--EEPVHFRPIYRGASAAFCIQLFCIDEKYE---ARSLDFMNFVFSLFSDKNFC--V 421

  Fly   447 MSVKYKASKSYLEVMQYFMPVASRPSNLSSLD-DVFITHRSTIFGEISLYKLEKEDVAHVHKLAL 510
            :|:.:...:.:|  :|.|:.:.  |.|..:|: |:::.||:.:...|::......|...|.
Human   422 ISLPHLTPEFFL--IQNFVKMV--PFNTCTLEQDLYVFHRAGLLKSINIRFATLLDTPGVE---- 478

  Fly   511 GNLPSNTQTPNSSSSSFSYCSKVNEREELEHELHVLDAIMKDVLENEFSEFAVFTIRCGISTRSV 575
             ||.|......|........:|.  |::.:..|  |.|.:.:|.|.
Human   479 -NLVSTLMLNKSILEDLDRYNKA--RKDPDGTL--LQAFVAEVAEQ------------------- 519

  Fly   576 RENTAIGFVIVREFHSHEKLFEHYHLPKQEYQLNRRRAE---IISLRLHPLFLVSAGLIFRDLAR 637
                .:|..::|.....|.:..||::....|..:.:|.|   :....|:|:|........:::.|
Human   520 ----IVGIAVIRNEMDIEYIRSHYNIEDFIYFSHHQREEHGHMHHFALNPIFRHYTKFFLKEILR 580

  Fly   638 ---KTSFYDYYFIHSVDG---YKYSNDLKKMMMVVEPKPIKKVPVFTRVQANHKKPRKKLDLPPP 696
               |:..|...:..|.:|   ..|::.|...:..:.|...::..|:...:.....|.|.:...|.
Human   581 LGFKSCLYYRVYPKSREGKFQNPYAHSLTSALHYLVPVRPRRQIVYPLEKLGINAPSKAVSKDPM 645

  Fly   697 NFSRDNLIIYRHKLNPVKWFTNSQKLVIIGFSAVTKAFLRQLVFQWNSKDHKNSENFTCLTRLQV 761
            :::.::.   ..||......|.:.|::::|.|:|..:||..|||..:.|       |..||.:..
Human   646 SYALNHT---NRKLTLEPKITVNAKIIVVGASSVGISFLETLVFCSHMK-------FNNLTLIST 700

  Fly   762 TVICRAGIVEADYDSLFKCPYCTNRQGCYLSYRNESCYVRDCCMRIDLRCWVHFVPGKVEKVDRD 826
            ..:....:::.:........:|.|.:...|               :.|..||:.|.|::..:||.
Human   701 HGLPGKKLLDTEQRKFLASDHCFNDKDYAL---------------MSLCSWVNVVVGRMTGIDRA 750

  Fly   827 KKFVKLDSCEIY-YDTLLLMCDRMFVLRC------------IDVPVYSPR------PCNLVEINF 872
            .|.|.|.:.||. ||.|:|...:.:.:.|            .:||..|.|      |||    :|
Human   751 AKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEADISQHLTNREVPNSSQRRYTGKVPCN----HF 811

  Fly   873 RLN------KFLLFYKVRALLEDMPRTYLVLVYGNNLHTYECIAFLIGHGVDCSRMVFVQP---H 928
            .||      |.|::.:..::..:..    ::||||.:.||..:..|:..||..||:..|||   .
Human   812 TLNEEEDCFKALIWIRNNSITTEGN----IIVYGNTIDTYTTVETLLNLGVSGSRIHLVQPPPAS 872

  Fly   929 RITGRDADMKEKCPYWDKNLQMIMDDILVEKGVNIFTDYDFHHYNLHKSTDFIMEVIFQHFPTQK 993
            .||..:          :.:::..:.|.|...||.::.|.....:|.....|.|....|. .|| |
Human   873 TITCIN----------NYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDPIYSASFT-TPT-K 925

  Fly   994 QMTFECDLFISFQEGHLHQRHKQWLENAGIELDGNQILVNERYQTNDPDVYAAGSFIKMRITPNY 1058
            ....:|.:|.||.|.::.....:.|.:|.:..| ::::::..:.|||..:.||||..|.   .|.
Human   926 PFRLQCSMFFSFCEKNVDYETFKALNDACLVYD-SRLVIDTNFHTNDIAIRAAGSLTKF---SNR 986

  Fly  1059 QY-------KFVSER---ELARKILHHLGIVTDKNFEDRFAEPVLFQAILPL------------- 1100
            .|       .|.|:.   :||..:||    :.|...|.....|.....::|:
Human   987 YYSNEWTHSNFSSKEIGFQLAAAMLH----LFDPTLEPVTEPPANLDRLIPMYKGAKIQGGILPG 1047

  Fly  1101 --RYF-ITKVTMPRRYLLSQVPVIKNCNLTT--YKNKTFCRVGLSTRMMVDEIVVVTKKECNLDF 1160
              .|. |.|..:|....:..........|.|  .||.|:.|:.::...||:.|..::::......
Human  1048 SYHYLHIAKPAIPTPLEVQMAQPNYGLELVTGSAKNGTYFRIHINKYKMVETITCLSREPFPASN 1112

  Fly  1161 LLYFCGKHELLLNKLKSRYRANLIHCFLKFFQEPWTELIMHDDFEELQAENKELLS 1216
            .:...|:||.|||.|.:||..|||.....:|.|||...:.||.|.:|:.|.:::|:
Human  1113 YIRLFGQHEQLLNNLCARYDENLITDLYSYFTEPWCLALFHDRFIDLRKELRQILA 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30275	NP_788430.3	CFAP61_N	5..279	CDD:465016	58/274 (21%)
		FadH2	791..>1047	CDD:440215	70/283 (25%)
CFAP61	NP_056400.3	CFAP61_N	17..266	CDD:465016	57/272 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..301		7/33 (21%)
		NirB	667..>772	CDD:440863	32/126 (25%)