DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS1 and slc17a5

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	476	Identity:	160/476 - (33%)
Similarity:	247/476 - (51%)	Gaps:	43/476 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TAETNTGPMIG-QRHLQTFLLFLSIVVNYMAKFNAGVAVVAM---TNAENTNP------NFP--- 53
            |.:....|..| .|:...||......|.|..:.|..||:|.|   ::..||:.      |.|
Zfish    23 TEDIQKAPACGSSRYGLAFLSCYGFFVAYALRVNLSVAMVDMLKNSSKANTSSSICPPHNIPVPK 87

  Fly    54 ------EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVS 112
                  .||||...:.:||.|||:|||:||..||:|.|:|||:..:.:..:.:.:..:|.|....
Zfish    88 HNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAKWLLGLGILCTVIFTLLTPLAAD 152

  Fly   113 WG-GWQAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLA 176
            .| |:  ..|:|:..|:.:|..:|.:||..|:|.|..||:||..::.||...||:||:..||.:
Zfish   153 LGAGY--LIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLTISYTGAQLGTVVALPLSGQI- 214

  Fly   177 ASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATG 241
            ...:.|..:||:...||:||..:|..|.:|.|...|.|.|||..||.:|:.:       ||..|.
Zfish   215 CFYLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTYIMSSLKN-------ELSPTQ 272

  Fly   242 PIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVM 306
            .. :||.:|:.|:|.||::|.....:|.:.||.|.:|.|||.||...::.|.:.||||||..|::
Zfish   273 DY-IPWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQNGMLSALPYLGCWLL 336

  Fly   307 AFVYLIIADILLTRGIMSITGIRKSVNSI-----AFFVPAAALIGVSFLDNTQKTLAVVLMCANV 366
            |.:...:||:|..|.:.....:||:...:     |.|:.||...|.:::      |||..:..:.
Zfish   337 ALLGGQLADLLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTGCNYI------LAVAFLTISS 395

  Fly   367 GINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISA 431
            .:...|..|..||.:|::|::||||:||.|:.:.|..::.|::...:.|.:...| |||||.|||
Zfish   396 SLGGISASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIARSLTKSNTIPE-WQIVFYISA 459

  Fly   432 VIFCVGNIVYVAFGKMVNQPW 452
            .|...|.:.:..|||...|||
Zfish   460 AINIFGAVFFTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	150/449 (33%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	156/458 (34%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	159/472 (34%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	137/397 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840