DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30203 and CG30046

DIOPT Version :9

Sequence 1:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	354/892 - (39%)
Similarity:	487/892 - (54%)	Gaps:	118/892 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IVLLILLSSEVRG-----VCNRIPQGASGPRSPVDDNFKILIDGNPETYVPEHQYNVSLSCPINM 64
            :|.|:||.|.|.|     :|.|.|.....|:||||:||.|.:.||||||:...:|||||:.....
  Fly     9 LVELLLLGSLVIGRVSSLICTRRPANTGSPKSPVDENFMISVSGNPETYILGQEYNVSLNAFNGH 73

  Fly    65 KFVSFTLVVEAEDPSAAFGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNAKIYIAVSWIAPRN 129
            :::||.:.:|.|  :..|...|..|.|||..:.:||||.:|.|||||||||:|.::.::|:||..
  Fly    74 RYISFIMALENE--NGDFSYNDDLGRFELSDLIETRFSPNCINMVENTNTNSKTHMHLTWVAPSE 136

  Fly   130 PDSGCVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDELNSL-TPPLET---CCACDEAKYEIVLE 190
            |.||||||:|.|.|||:||.:|||.||||||.|..|::.|. |.|...   |||||||:||::.|
  Fly   137 PGSGCVLIRATVQQHREVWHMDDGGLTKRICEEVTDDVESQPTAPAAVDVPCCACDEARYELIFE 201

  Fly   191 RKWARNTHWKDFPSEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHGATRTLENEIREN 255
            ..|:||.|.||||:..|.||..|::||:||..||:|..|..||..|||.|||.::|.||.|...|
  Fly   202 GVWSRNLHPKDFPTRGWETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHCSSRLLEREFSIN 266

  Fly   256 TQNGEVRTIIKAPGIPYRPKTFGTTLANARLDPVHHQISLAAKIDPSPDWILGVAGLELCLSNCT 320
            .::.::||||||.| |..|.....|:|:.|:||:||.:|.|:||:||||||:||.||||||.|||
  Fly   267 FRDQKIRTIIKARG-PSYPNISSKTMASVRVDPIHHMVSFASKIEPSPDWIVGVTGLELCLRNCT 330

  Fly   321 WLERKVLNLYPWDIGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDHRSPFYDDTGAPMKPLATLY 385
            |:|.||:||||||:||||||:|.|||:|||||||:||:.|.:|:|.||||||.:|.||||:|.|.
  Fly   331 WMEEKVINLYPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFYDISGTPMKPMAILT 395

  Fly   386 LTRKKLYIRECEEVPQEG----PLECAVHPWNEWTNCSTRCGQGYSHRQRSFKNPNLAANFNCDR 446
            :.|:::|.|.|.:.....    |.||..|||:.|::||::||.|..:|:|.:|.|.||..:||:.
  Fly   396 VKRQRIYERRCADEDSNNDPDVPRECFTHPWSSWSDCSSKCGVGMQYRRRVYKQPELARVYNCNE 460

  Fly   447 RLEEFRQCQGTQCG-----AAEEELEGEEPG---LGMENPPSSGSMAECQLTNWGEWSPCTKTCG 503
            ...|.|:|||..||     ...||.|..||.   :|.:  ||....|||:|::||.||||:.|||
  Fly   461 AQYEERECQGEMCGQNNLMREPEEFEDLEPDPRRIGYQ--PSQQRRAECELSSWGSWSPCSVTCG 523

  Fly   504 RGSSTRTRDYYNPQARQRCLSVMRIPLEETRECIGSDCGGTIPDN--------------GELDG- 553
            .|...|.|.|.||||...|..|.|:.|:|||:|.|.||.|::|.:              |.:.|
  Fly   524 DGYEMRQRQYLNPQAEFDCQGVHRMELQETRKCSGRDCLGSLPGSYSTDMDSPYGGASPGRIGGN 588

  Fly   554 ------FPEPDVFGETD--HGGYMGKTTSWNSKQEHSSLGS-GNQAWNRKPYNSWKDKSLSNP-- 607
                  .||.:.||:.|  ..|.:|.....|.|      |: ||.|.||:. |..:|.....|
  Fly   589 MYGPQLEPEAENFGDYDDSRNGAVGGFEVGNLK------GNIGNWALNRQT-NLGRDVPSLRPTN 646

  Fly   608 ----RDNAQESPNLPFDQIENPQRPAYNPSDNMGGYDKGFPPTNSYSN----DKLVGNRPGYNDF 664
                |..|::|....:.....|..|.....:....:.:  .|:|.|.:    .::|..|..:...
  Fly   647 YDRARQQAEKSERTTWSGQSRPDDPRLEDVERAPWHRQ--RPSNKYGSIVEAPEMVSPREPWQRA 709

  Fly   665 NSDYNNKDAYNDYTTPSFTSRTPFGSRYPNQQETVEGNTNDINGNYNVVQDYCFEKPYASTLPCF 729
            | ::.|.|.|           ||.|...|:.             :|.     ||:....:...|.
  Fly   710 N-NFGNPDMY-----------TPGGDVDPSL-------------SYR-----CFQMVQTAQPRCH 744

  Fly   730 AKPVVESNYWFYDHEDHECKIFTTDNCDQNRNRFRTLTACEGTCLQPQINMERSENDAMDLYGRR 794
            .: .:..::|||:....||.::..|.||:|.|:||....|| .|.||               |..
  Fly   745 DQ-TITGHFWFYNFCADECMLYAADQCDRNVNKFRRWEDCE-KCRQP---------------GMA 792

  Fly   795 SYDQKQTRGRPYDQTSGIAYGQTEGRSYDQKVGKSYDRTFGRSYKQT 841
            :..|:.|.....:....|  .|.|.|:.::|...:..|.:|.|..:|
  Fly   793 ALQQEHTNSPQCEDFRAI--WQAEQRAREEKRPSNRRRNYGDSRYRT 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	71/141 (50%)
		Spond_N	183..372	CDD:283999	110/188 (59%)
		TSP1	411..459	CDD:214559	21/47 (45%)
		TSP1	492..541	CDD:214559	26/48 (54%)
		KU	<739..773	CDD:197529	14/33 (42%)
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	71/140 (51%)
		Spond_N	194..382	CDD:283999	110/188 (59%)
		TSP1	425..473	CDD:214559	21/47 (45%)
		TSP1	510..561	CDD:214559	26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438634
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	P	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
	10	9.840