DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30203 and Spon1

DIOPT Version :9

Sequence 1:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_663559.1	Gene:	Spon1 / 233744	MGIID:	2385287	Length:	807	Species:	Mus musculus

Alignment Length:	643	Identity:	195/643 - (30%)
Similarity:	302/643 - (46%)	Gaps:	109/643 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GVCNRIPQGASGPRSPVDDNFKILIDGNPETYVPEHQYNVSLSCPINMKFVSFTLVVEAEDPSAA 81
            |.|:||.: |.|.|......|.:.::|:|:.|.|...|.|:||......|..|||:...|:....
Mouse    42 GYCSRILR-AQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIALKENQEGD 105

  Fly    82 FGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNAKIYIAVSWIAPRNPDSGCVLIKAGVVQHRD 146
             ..:|..|.|:::...:|:|.::|...|..:....:..|.|.||||.. .:|||::||.:||.|.
Mouse   106 -KEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPT-GTGCVILKASIVQKRI 168

  Fly   147 VWFLDDGFLTKRICPEEIDELNSLTP-PLETCCACDEAKYEIVLERKWARNTHWKDFP--SEDWR 208
            ::|.|:|.|||::| |:...|:.:|. |:..||||..|||.:.....|:..||.||:|  :..|
Mouse   169 IYFQDEGSLTKKLC-EQDPTLDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHW- 231

  Fly   209 TRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHGATRTLENEIRENTQNGEVRTIIKA----PG 269
               ..:||.|||.:|..|.|||.||:|:|::||.|:...:|.|||:  |:.||.|:|||    |.
Mouse   232 ---SAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQ--QSDEVLTVIKAKAQWPA 291

  Fly   270 IPYRP-KTFGTTLANARLDPVHHQISLAAKIDPSPDWILGVAGLELCLSNCTWLERKVLNLYPWD 333
              ::| .......|...:|...|.:|....:.|||||.:|::..:||...|.|:::.|.:|.|||
Mouse   292 --WQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWD 354

  Fly   334 IGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDH-RSPFYDDTGAPMKPLATLYLTRKKLYIRECE 397
            .|||||.:|.|.::|.:|.:.:|.:||   .|| :|||||..|..:..:|.:.:.|......:|.
Mouse   355 AGTDSGVTYESPNKPTIPQEKIRPLTS---LDHPQSPFYDPEGGSITQVARVVIERIARKGEQCN 416

  Fly   398 EVP-----------------QEGPLECAVHPWNEWTNC-STRCGQGYSHRQRSFKNPNLAANFNC 444
            .||                 .:.|..|....|:.|:.| |:.|.:|...|||..| ..|..:..|
Mouse   417 IVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLK-AQLDLSVPC 480

  Fly   445 DRRLEEFRQCQGTQCGAAEEELEGEEPGLGMENPPSSGSMAECQLTNWGEWSPCTKTCGRGSSTR 509
            . ..::|:.|.|..|        .:|.|            :.|.::.|..||||:.:||.|  .|
Mouse   481 P-DTQDFQPCMGPGC--------SDEDG------------STCTMSEWITWSPCSVSCGMG--MR 522

  Fly   510 TRDYYNPQARQRCLSVMRIPLEETREC-IGSDCGGT---IPDNGELDGFPEPDVFGETDHGGYMG 570
            :|:.|..|..:.. ||..:|.|||.:| :..:|..:   :.:.||.|.               ..
Mouse   523 SRERYVKQFPEDG-SVCMLPTEETEKCTVNEECSPSSCLVTEWGEWDD---------------CS 571

  Fly   571 KTTSWNSKQEHSSL------GSGNQAWNRK-----------------PYNSWKDKSLS 605
            .|.....|:.|..:      ||..:|...:                 |::.|.|.|::
Mouse   572 ATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVT 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	47/141 (33%)
		Spond_N	183..372	CDD:283999	76/196 (39%)
		TSP1	411..459	CDD:214559	15/48 (31%)
		TSP1	492..541	CDD:214559	19/49 (39%)
		KU	<739..773	CDD:197529
Spon1	NP_663559.1	Reeler	43..182	CDD:260081	47/141 (33%)
		Spond_N	205..392	CDD:283999	77/197 (39%)
		TSP_1	446..494	CDD:278517	15/49 (31%)
		TSP_1	505..554	CDD:278517	19/51 (37%)
		TSP_1	562..610	CDD:278517	9/62 (15%)
		TSP_1	618..665	CDD:278517	4/12 (33%)
		TSP_1	672..720	CDD:278517
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..752
		TSP_1	758..807	CDD:278517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831120
Domainoid	1	1.000	184	1.000	Domainoid score	I3399
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1946
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.710