DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30203 and spon-1

DIOPT Version :9

Sequence 1:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_495473.2	Gene:	spon-1 / 174169	WormBaseID:	WBGene00006893	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	843	Identity:	232/843 - (27%)
Similarity:	352/843 - (41%)	Gaps:	197/843 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRHIVLLILLSS----EVRGVCNRIPQGASGPRSPVDDNFKILIDGN-------PETYVPEHQY 54
            :|:.|:||:|:.|    |.:  |...|..|.|.:||..:.:.|.|:|.       .:.:||...|
Worm     7 ILQFILLLLLIFSCNADEAK--CTIKPYEAKGDKSPGSNGYVIEINGTTTKSMDISKGFVPGEIY 69

  Fly    55 NVSL---SCPINMK-FVSFTLVVEAEDPSAAFGGQDMTGHFELLGVGDTRFSTSC-ENMVENTNT 114
            .||:   .....:| |..|.:....||.::|...|.:.||      ||.|.|..| ::.|.:.|.
Worm    70 KVSIRGWRTQYTVKTFRGFVVSSLFEDNTSAGSWQVVKGH------GDARISPGCRQSGVSHANL 128

  Fly   115 NAKIYIAVSWIAPRNPDSGCVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDE-LNSLTPPLETCC 178
            .:|..:.:.|.|| ...||||:.:|.|::.:.:||.:...||.::|.::..: |..:..|..|||
Worm   129 KSKTSVHMMWKAP-EVSSGCVVFRASVIETKYIWFTEAEGLTVKLCIQKGTQILKPVDDPSATCC 192

  Fly   179 ACDEAKYEIVLERKWARNTHWKDFPSEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHG 243
            |||.|:|::.....|::|||.||:|:.:..|...:::|:|||.:|..|..||.::.||||:||.|
Worm   193 ACDIAQYDLEFTGIWSKNTHPKDYPTLEHLTHFTDMLGSSHSSNYSLWTIGGISTDGMKEIAEWG 257

  Fly   244 ATRTLENEIRENTQNGEVRTIIKAPGIPYRPKTFGTTLANARLDPVHHQISLAAKIDPSPDWILG 308
            .|...|.|.:  .:..|||:::|..|: :.|...|||.:...::..||.:|||....|||||.:|
Worm   258 NTYKAEAEAK--AKASEVRSLMKVKGL-WFPDVQGTTKSQFVVNKYHHFVSLATMFGPSPDWCVG 319

  Fly   309 VAGLELCLSNCTWLERKVLNLYPWDIGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDHRSPFYDD 373
            ::.:.|||.:|||.|.:...|.|:|.||||||:|||.:||..|.:.:..||:..  :..||||:.
Worm   320 LSSVNLCLPDCTWAEERTFELQPFDAGTDSGPTYMSPNEPTEPREPIHWITTKL--NPLSPFYNS 382

  Fly   374 TGAPMKPLATLYLTRKKLYIREC-----------------EEVPQEGPLECAVHPWNEWTNCSTR 421
            ....:..||.:.|.||.:...||                 |:...:...||.:..|..|:.||..
Worm   383 KSDTIPTLAKVILRRKNVTSSECKSDDILKAEAHNITNTSEDEEYKDRRECMMTQWEPWSLCSAT 447

  Fly   422 CGQGYSHRQRSFKNPNLAANFNCDRRLEEFRQCQG--TQCGAAEEELEGEEPGLGMENPPSSGSM 484
            ||:|...|.|.:..|..|..|:|.|:..|.:.|..  .:|                ||  |....
Worm   448 CGKGIRIRSRVYVFPIKAQVFHCHRQTTEKQFCNAKINEC----------------EN--SEAFS 494

  Fly   485 AECQLTNWGEWSPCTKTCGRGSSTRTRDYYNPQARQRCLSVMRIPLEETRECI---GSDCGGTIP 546
            ::||:::||.|..|:..||.|..:|.|.:.||..:....||   .||....|:   |.||..|
Worm   495 SKCQVSSWGSWGECSVQCGHGMRSRNRTFLNPATKSGDCSV---DLERKDICVGENGDDCNVT-- 554

  Fly   547 DNGELDGFPEPDVFGETDHGGYMGKTTSWNSKQEHS-SLGSGNQAWNRKPYNSWKDKSLSNPRDN 610
                    |:|           :.|||:|:.....| |...|.:...|..:.|..:|...:.  |
Worm   555 --------PDP-----------LCKTTAWSDWSPCSASCDEGVRVRTRLFFYSEHEKRCMHV--N 598

  Fly   611 AQESPNLPFDQIENPQRPAYNPSDNMGGYDKGFPPTNS---YSNDKLVGNRPGYNDFNSDYNNKD 672
            .||.........                  :.|...||   ...||..|...|
Worm   599 LQEKDTCVMQSC------------------RRFIEINSEEICQEDKQAGQCAG------------ 633

  Fly   673 AYNDYTTPSFTSRTPFGSRYPNQQETVEGNTNDINGNYNVVQDYCFEKPYASTLPCFAKPVVESN 737
                              .:|                                           .
Worm   634 ------------------NFP-------------------------------------------R 637

  Fly   738 YWFYDHEDHECKIFTTDNCDQNRNRFRTLTACEGTCLQPQINMERS---ENDAMDLYGRRSYD 797
            || |:||..:|:.|....|..|||:|.|...|:..|| |.....:|   .|..::.:|....|
Worm   638 YW-YNHEKTQCERFIFTGCKGNRNQFETEEECKQICL-PGYEKSKSLIPNNQLLEDFGNTEVD 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	44/153 (29%)
		Spond_N	183..372	CDD:283999	75/188 (40%)
		TSP1	411..459	CDD:214559	16/49 (33%)
		TSP1	492..541	CDD:214559	17/51 (33%)
		KU	<739..773	CDD:197529	13/33 (39%)
spon-1	NP_495473.2	Reeler	36..171	CDD:260081	41/141 (29%)
		Spond_N	197..381	CDD:283999	75/188 (40%)
		TSP1	435..481	CDD:214559	15/45 (33%)
		TSP1	499..551	CDD:214559	17/54 (31%)
		TSP1	562..610	CDD:214559	11/49 (22%)
		Kunitz_BPTI	621..672	CDD:278443	19/124 (15%)
		TSP1	708..759	CDD:214559
		TSP1	766..816	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156312
Domainoid	1	1.000	57	1.000	Domainoid score	I7227
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.660