Protein Alignment NT5E-2 and SMN1

DIOPT Version :10

• Sequence 1: NP_611218.1
• Gene: NT5E-2 / 246458
• FlyBaseID: FBgn0050104
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_012072.3
• Gene: SMN1 / 856609
• SGDID: S000001245
• Length: 602
• Species: Saccharomyces cerevisiae
• Alignment Length: 632
• Identity: 119/632 - (18%)
• Similarity: 212/632 - (33%)
• Gaps: 198/632 - (31%)

  Fly    36 LHNNDMH----ARFDQTSVNSGTCPPEDVHTNKCYGGFARVAHEVR-KYRKEAQEGGTSVLYLNA 95
            :|..|.|    :...|...::.            :|.|......:| |..:::::    |:.::.
Yeast    47 IHTTDTHGWLGSHLSQNDYDAD------------WGDFVAFVDILREKILRQSRD----VIVIDT 95

  Fly    96 GDTYTG-----TSWFTIFKDKIASAFLNKLKPDAISLGNHEFDERVEGLIPFLNEVTFPVLACNL 155
            ||...|     .:|....:   :|...|.:..|.::|||||.......::.:..
Yeast    96 GDKRDGNGLSDATWPPGLR---SSEIFNMMDYDLLTLGNHELYTAESAILEYRG----------- 146

  Fly   156 DLSKVPQLKATWHLANSAILETNGTKV----GVIGYLTPDTKKLTLNMDVEFN------------ 204
             .|:..:.|..:..:|...:|.:||:|    ..|.:.||..|:..|.:...|:
Yeast   147 -TSQSSKFKDKYVCSNVEFIEDDGTRVPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTP 210

  Fly   205 --EEVESIN-----VEAKKLKAQGIKIIIALGHSGYLKDLE---------IAKNCPEVDI-VIGG 252
              ||:...:     ||..  :.:.|.:||..||.......|         |.|..|...| ..||
Yeast   211 PLEEITQKSWFQNMVETN--REEEIDLIIVFGHLPATDPTEREMHKIHALIRKYYPNTVIQYFGG 273

  Fly   253 HT-----------NTFLYTGAQPD---------AEHIDGPYPTMVKQ--NSGKEVPVVQAYAYTK 295
            ||           :|.|.:|...:         .:.:|...|...::  :..||       |:..
Yeast   274 HTHIRDFVQLDSKSTCLQSGRFAETVGFLSINMTDPVDAESPIFSRRYIDFNKE-------AFKY 331

  Fly   296 YLGKL-HVQFDADGNLIQWDGSPILLNASVAQEQDLLDLLEVFRPNVTRLEKSVVGHTKVHLEGN 359
            :|.|| |     |.|:      |:    |..:.:.:..|:...|..:...||  :|:.......:
Yeast   332 HLSKLGH-----DSNV------PV----STKKGKTISRLVNDLRHELNLNEK--LGYIPQTYYVS 379

  Fly   360 KAVCRAEECNLGNLIADAMV------------FSRLMEEQGGDFWTDAAISIMQGGGIRSSIEKR 412
            .....:|| ||.:||...::            .||.:              ::..|.:|..:.|
Yeast   380 TRPLNSEE-NLYHLITHKILPNLIPPKNYEPSMSRFI--------------LINTGSVRYDLYK- 428

  Fly   413 SDGAITDNDILSVLPWGN--KLYMVPM-TGSTIRRALEHGAALRG---------KDSDGGFLQVS 465
              |..|.:....|:|:.|  :...||: ..|.:...|..|..:..         |...|||.:..
Yeast   429 --GPFTKDTEYIVMPFNNDWRFITVPLVVASRVETYLNKGPVIASLGIPSSSHHKQHFGGFQKCP 491

  Fly   466 GIRVVFNSNKPEG------------------QRVVSVQ--VRCAACRVPTYSDLNDTAIYNVVLG 510
            .|.   |.|..||                  ||...:.  |:|...:.....:.:.:.:.:|:..
Yeast   492 FIN---NPNLSEGYTTEDDFGCHGDDTPHNSQREYDIPNVVQCKEVKKVQEEEADPSKMVHVIFY 553

  Fly   511 EFL-LD--GGDGHVMRDSAHQPQRLQNNDL-----EAVSQYLNQRDY 549
            .|: ||  .....::.|...:.:.|..||.     ::..:.|  |||
Yeast   554 SFMELDILNAVNSIINDLGLRMENLTTNDCSHYGGDSTKKLL--RDY 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NT5E-2	NP_611218.1	MPP_CD73_N	33..320	CDD:277354	67/349 (19%)
		5_nucleotid_C	348..519	CDD:427027	39/217 (18%)
SMN1	NP_012072.3	MPP_YHR202W_N	39..325	CDD:277352	57/310 (18%)