DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NT5E-2 and nt5e

DIOPT Version :9

Sequence 1:	NP_611218.1	Gene:	NT5E-2 / 246458	FlyBaseID:	FBgn0050104	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_957226.1	Gene:	nt5e / 393906	ZFINID:	ZDB-GENE-040426-1261	Length:	571	Species:	Danio rerio

Alignment Length:	566	Identity:	232/566 - (40%)
Similarity:	345/566 - (60%)	Gaps:	33/566 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EFIILHNNDMHARFDQTSVNSGTC--PPEDVHTNKCYGGFARVAHEVRKYRKEAQEGGTSVLYLN 94
            :..:||.||:|||.::|:.:||.|  ||       |:.|.:|.:.::::.|.:.:    :||.|:
Zfish    26 QLTLLHTNDVHARVEETNKDSGKCSKPP-------CFAGVSRRSTKIKEIRSKEK----NVLLLD 79

  Fly    95 AGDTYTGTSWFTIFKDKIASAFLNKLKPDAISLGNHEFDERVEGLI-PFLNEVTFPVLACNLDLS 158
            |||.:.||.||..:|...|:.|:|:||.||::|||||||..|:||: |||.||...||:.|:...
Zfish    80 AGDQFQGTVWFNYYKGAEAAYFMNQLKYDAMALGNHEFDNGVDGLLKPFLQEVNCTVLSANIKAD 144

  Fly   159 KVPQLKATWHLANSAILETNGTKVGVIGYLTPDTKKLTL-NMDVEFNEEVESINVEAKKLKAQGI 222
            :....:.:.:.....|......||||:||.:.:|..|:| ...::|.:|:.::..:..||...|:
Zfish   145 ETLAPRISGYYFPYKIFTLGSEKVGVVGYTSAETPALSLPGPHLKFEDEITALQPQVDKLLTLGV 209

  Fly   223 KIIIALGHSGYLKDLEIAKNCPEVDIVIGGHTNTFLYTGAQPDAEHIDGPYPTMVKQNSGKEVPV 287
            ..||||||||:|.|..|||....||:|||||||||||||..|..|...||||.|||.:.|::|||
Zfish   210 NKIIALGHSGFLMDQMIAKKVQGVDVVIGGHTNTFLYTGDPPSTEVPAGPYPLMVKSDDGRQVPV 274

  Fly   288 VQAYAYTKYLGKLHVQFDADGNLIQWDGSPILLNASVAQEQDLLDLLEVFRPNVTRLEKSVVGHT 352
            |||||:.||||.|.|.|||:||:::..|:|||||:||..:.|:...::.:|.|:.......||.|
Zfish   275 VQAYAFGKYLGFLKVTFDANGNVLESTGNPILLNSSVEPDPDIQAKVDSWRMNLANYSSQQVGQT 339

  Fly   353 KVHLEGNKAVCRAEECNLGNLIADAMVFSRLM---EEQGGDFWTDAAISIMQGGGIRSSIEKRS- 413
            .|.|.|....||..||||||||.||||...:.   |.|    |...:..|:.|||||..|::|:
Zfish   340 LVFLNGTFEECRFRECNLGNLICDAMVHHNIKYADELQ----WNHVSSCILNGGGIRGPIDERNR 400

  Fly   414 DGAITDNDILSVLPWGNKLYMVPMTGSTIRRALEHGAALRGKDSDGGFLQVSGIRVVFNSNKPEG 478
            :|:||..|:::|||:|....:|.:.|||:..|.||.....|.:: |.||||||.:||::.:|..|
Zfish   401 NGSITMEDLIAVLPFGGTFDLVQLNGSTLLEAFEHSVRRHGGNT-GEFLQVSGFQVVYDLSKAPG 464

  Fly   479 QRVVSVQVRCAACRVPTYSDLNDTAIYNVVLGEFLLDGGDGHVMRDSAHQPQRLQNN----DLEA 539
            .||.||:|.|..||||.|..|....:|.|||..:|:|||||..|    .:.::|:::    |:..
Zfish   465 SRVKSVKVLCTQCRVPHYEPLVPNKVYKVVLPSYLVDGGDGFTM----IKEKKLKHDSGDLDISV 525

  Fly   540 VSQYLNQRDYVYPEIEGRIIFINASSTLMG-SAALLLISSLLIKII 584
            |:.|:::|..|:|.:|||..|.::.:.|.| ::.:||:.::.:.::
Zfish   526 VAGYISERKRVHPAVEGRFQFSSSCAGLRGYTSTVLLLWAVWLMLV 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NT5E-2	NP_611218.1	MPP_CD73_N	33..320	CDD:277354	128/290 (44%)
		nadN	35..520	CDD:211667	215/492 (44%)
		5_nucleotid_C	348..519	CDD:280945	78/174 (45%)
nt5e	NP_957226.1	UshA	23..525	CDD:223808	219/518 (42%)
		MPP_CD73_N	27..307	CDD:277354	128/290 (44%)
		5_nucleotid_C	335..505	CDD:280945	78/174 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594714
Domainoid	1	1.000	159	1.000	Domainoid score	I4048
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1830
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm26617
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	LDO	PTHR11575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5252
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840