Protein Alignment ATP6V1C2 and Vha44

DIOPT Version :8

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001137679.1
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0262511
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 878
• Identity: 225/879 (26%)
• Similarity: 302/879 (34%)
• Gaps: 488/879 (56%)

Human     1 MSEFWLISAPGDKENLQALERMNTVTSKS-NLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFA 64
            |||:|:|||||||...|..:.||.:|||. ||..|.||.|||.||||||.||||||:||||||:.
  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66

Human    65 ESLIRRMAQSVVEVMEDSKGKVQEHLLANGG---------------------------------- 95
            |.:.|::|..:.||:||.:.|:.|:|:||..
  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131

Human    96 -----------------LKGK-------------------------------------------- 99
                             ||||
  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196

Human   100 -----------------------------------------------MKC--------------- 102
                                                           .:|
  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456

Human   103 ------------------------------------------LKI-------------------- 105
                                                      |.|
  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521

Human   106 ------------------------DLTSFVTHFEWDMAKYPVKQPLVSVVDTIAKQLAQIEMDLK 146
                                    :|..::|.|:|||||||:||.|.::.|.|:||:.||:.|||
  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586

Human   147 SRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVIVPKPNYSQWQKTYE 211
            :::.|||.||.||:|||||..|:|.||.|:|:|.||.|:||||||.||||||||...:.|...||
  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651

Human   212 SLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMAR 276
            .::||:||||::||.||.:..||.||||:||.|:||..|:|.||.||:|.|:|:|:...:.||.:
  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716

Human   277 LLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERESEGEGEGPLLRWLKVN 341
            |::|||:|:                                              |||:||||||
  Fly   717 LMTDKKKQF----------------------------------------------GPLVRWLKVN 735

Human   342 FSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSI 406
            |||||.|.||:|||||||||||||||||||||:|::|:|| |.||||:|||.::.|||..:|...
  Fly   736 FSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKK-SVKRLRDVLNQLYGHLDGASAGGA 799

Human   407 LDA--SVEIPGLQLNNQDYFPYVYFHIDLSLLD 437
            :.:  :|:||||.....:|||||::.:::.:::
  Fly   800 VSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:308707	221/863 (26%)
		3-helical coiled coil	55..75	CDD:270211	10/20 (50%)
		3-helical coiled coil	130..156	CDD:270211	13/26 (50%)
		3-helical coiled coil	284..361	CDD:270211	26/77 (34%)
Vha44	NP_001137679.1	V-ATPase_C	6..>98	CDD:301617	52/92 (57%)
		3-helical coiled coil	57..77	CDD:270211	10/20 (50%)
		V-ATPase_C	<547..822	CDD:281248	162/322 (50%)
		3-helical coiled coil	570..596	CDD:270211	13/26 (50%)
		3-helical coiled coil	724..755	CDD:270211	26/77 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C34172251
eggNOG	1	0.900				E1_COG5127
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1016088at2759
OrthoFinder	1	1.000				FOG0001431
OrthoInspector	1	1.000				T609581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR10137
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1630
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	10	9.840