Protein Alignment ATP6V1C2 and atp6v1c2

DIOPT Version :8

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: XP_002940167.1
• Gene: atp6v1c2 / 100485790
• XenbaseID: XB-GENE-962058
• Length: 381
• Species: Xenopus tropicalis
• Alignment Length: 437
• Identity: 274/438 (63%)
• Similarity: 334/438 (76%)
• Gaps: 57/438 (13%)

Human     1 MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAE 65
            |||.||||.||||.||.||:||||||||:|||.|.||.||:.||||||:||||||||||||.:||
 Frog     1 MSELWLISVPGDKTNLTALDRMNTVTSKANLSSNAKFVIPELKVGTLDALVGLSDELGKLDAYAE 65

Human    66 SLIRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKIDLTSFVTHFEWDMAKYPVKQPLVSV 130
            |||:::||.:.|||:||..|.||:|||||          :||.|::..||||||||||||||.::
 Frog    66 SLIKKIAQYIGEVMDDSTDKAQENLLANG----------VDLISYLARFEWDMAKYPVKQPLKNI 120

Human   131 VDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLL 195
            ::.::||::||:.|||||::|||.:|.:|::||:|::|||.||||:|||:|||||||||||||||
 Frog   121 MEVLSKQMSQIDTDLKSRSSAYNNIKGSLQSLERKTVGNLLTRTLADIVNKEDFVLDSEYLVTLL 185

Human   196 VIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREF 260
            |:|||.:|..||||||||||||||||||:|.||.|||||||||||||::|||.||:||||.||||
 Frog   186 VVVPKSSYGAWQKTYESLSDMVVPRSTKMIAEDAEGGLFTVTLFRKVMDDFKAKARENKFIVREF 250

Human   261 YYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERE 325
            .::|||::.|:.|:.:|.:||||.|
 Frog   251 LFNEKELQSEKAEIVKLAADKKQLY---------------------------------------- 275

Human   326 SEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREV 390
                  ||||||||||||||||.||||||||||||||||||||||||||:|||:|| |.||||:|
 Frog   276 ------GPLLRWLKVNFSEAFIGWIHIKALRVFVESVLRYGLPVNFQAVVLQPNKK-SMKRLRDV 333

Human   391 LNSVFRHLDEVAATSILDASVEIPGLQLNNQDYFPYVYFHIDLSLLD 437
            ||::||||||.||.::.|..:|||||||::|||:|||.|.|||:.||
 Frog   334 LNAIFRHLDENAAANMKDIGMEIPGLQLSSQDYYPYVCFKIDLTNLD 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:308707	264/422 (63%)
		3-helical coiled coil	55..75	CDD:270211	14/20 (70%)
		3-helical coiled coil	130..156	CDD:270211	12/26 (46%)
		3-helical coiled coil	284..361	CDD:270211	29/77 (38%)
atp6v1c2	XP_002940167.1	V-ATPase_C	5..370	CDD:281248	264/422 (63%)
		3-helical coiled coil	55..75	CDD:270211	14/20 (70%)
		3-helical coiled coil	120..146	CDD:270211	12/26 (46%)
		3-helical coiled coil	274..305	CDD:270211	29/77 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C34021581
eggNOG	1	0.900				E1_COG5127
Hieranoid	1	1.000
Homologene	1	1.000				H15866
Inparanoid	1	1.050	540	1.000	Inparanoid score	I6614
OMA	1	1.010
OrthoDB	1	1.010				D1016088at2759
OrthoFinder	1	1.000				FOG0001431
OrthoInspector	1	1.000				T1884517
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1630
TreeFam	1	0.960
	12	11.800