DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FXN and fxn

DIOPT Version :9

Sequence 1:	NP_000135.2	Gene:	FXN / 2395	HGNCID:	3951	Length:	210	Species:	Homo sapiens
Sequence 2:	NP_001076485.1	Gene:	fxn / 556389	ZFINID:	ZDB-GENE-070209-286	Length:	169	Species:	Danio rerio

Alignment Length:	183	Identity:	94/183 - (51%)
Similarity:	116/183 - (63%)	Gaps:	30/183 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    29 RPAELAPLCGRRGLRTDIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLG-----HPG 88
            |....|.:|||.       ..|           .::|.|  |:.::|     ||.||     |..
Zfish    12 RSVSSANICGRH-------TQC-----------FDRILN--KRDLHL-----SGPLGEEKAHHLR 51

Human    89 SLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQ 153
            .:.|..||||||||||:||::||||.|:.:|..||||.|.:||||||:|.|.|||||||||||:|
Zfish    52 EISEAEYERLAEETLDALADYFEDLTDENFTGLDYDVVFSNGVLTVKVGSDHGTYVINKQTPNRQ 116

Human   154 IWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYS 206
            ||||||:||||||||||:.|||:||.|.||.||:.||:...||.:|||.|.:|
Zfish   117 IWLSSPTSGPKRYDWTGERWVYTHDAVPLHSLLSKELSIIFKTNIDLSHLIHS 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FXN	NP_000135.2	mito_frataxin	94..192	CDD:132463	71/97 (73%)
fxn	NP_001076485.1	Frataxin_Cyay	54..161	CDD:279789	74/106 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331916
Domainoid	1	1.000	161	1.000	Domainoid score	I16507
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H47908
Inparanoid	1	1.050	171	1.000	Inparanoid score	I11387
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1372185at2759
OrthoFinder	1	1.000	-	-		FOG0004275
OrthoInspector	1	1.000	-	-		oto45590
orthoMCL	1	0.900	-	-		OOG6_102217
Panther	1	1.100	-	-	LDO	PTHR16821
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.400