Protein Alignment FXN and fh

DIOPT Version :10

• Sequence 1: NP_000135.2
• Gene: FXN / 2395
• HGNCID: 3951
• Length: 210
• Species: Homo sapiens
• Sequence 2: NP_511094.1
• Gene: fh / 31845
• FlyBaseID: FBgn0030092
• Length: 190
• Species: Drosophila melanogaster
• Alignment Length: 185
• Identity: 77/185 - (41%)
• Similarity: 105/185 - (56%)
• Gaps: 17/185 - (9%)

Human    38 GRRGLRTDIDATC--TPRRASSNQRGLNQIWNVKKQSV---------YLMNLRK-SGTLGHPGSL 90
            ||..:|:.:...|  |..|.|..|...:|:......::         :..|.|. |..:....:|
  Fly     4 GRLMVRSIVGRACLATMGRWSKPQAHASQVILPSTPAIAAVAIQCEEFTANRRLFSSQIETESTL 68

Human    91 DETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIW 155
            |..||||:..:|||:|.::||:|.:.....:..||::..|||||.|||..||||||:||||||||
  Fly    69 DGATYERVCSDTLDALCDYFEELTENASELQGTDVAYSDGVLTVNLGGQHGTYVINRQTPNKQIW 133

Human   156 LSSPSSGPKRYDWTGK----NWVYSHDGVSLHELLAAELTKALKTK-LDLSSLAY 205
            ||||:|||||||:.|.    .|:|.|.|.||||||..|:...||:: :|...|.|
  Fly   134 LSSPTSGPKRYDFVGTVAAGRWIYKHSGQSLHELLQQEIPGILKSQSVDFLRLPY 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FXN	NP_000135.2	mito_frataxin	94..192	CDD:132463	58/101 (57%)
fh	NP_511094.1	mito_frataxin	72..173	CDD:132463	58/100 (58%)