Protein Alignment HEY2 and E(spl)m7-HLH

DIOPT Version :10

• Sequence 1: NP_036391.1
• Gene: HEY2 / 23493
• HGNCID: 4881
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Alignment Length: 205
• Identity: 58/205 - (28%)
• Similarity: 90/205 - (43%)
• Gaps: 43/205 - (20%)

Human    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFD 113
            ||..:.::|::||.|||..|.||:.|:.....:.|.||.|||:||::||.||:.|:.:      .
  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKES------K 72

Human   114 AHALAMDFMSI--GFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHH 176
            .|..|....|.  |:.....||:|.|:|:..:|.:  ....|::||.....|.|
  Fly    73 KHVPANPEQSFRAGYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE----------- 124

Human   177 HHPLHPHHWAAAFHHLPAALLQP----NGLHASESTPCRLSTTSEVPP-AHGSALLTATFAHADS 236
             .|:..          |.|:..|    .|..:|.||....|:.|.:.| :.|.|      :..:|
  Fly   125 -QPMEQ----------PQAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYA------SDNES 172

Human   237 ALRMPSTGSV 246
            .|::.|.|.|
  Fly   173 LLQISSPGQV 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH-O_HEY2	40..121	CDD:381490	27/71 (38%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		25/66 (38%)
		ORANGE	119..165	CDD:128787	12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..337
		YRPW motif	327..330
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	25/64 (39%)
		ORANGE	81..125	CDD:128787	13/57 (23%)