DRSC/TRiP Functional Genomics Resources

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Protein Alignment HEY2 and dpn

DIOPT Version :10

Sequence 1:NP_036391.1 Gene:HEY2 / 23493 HGNCID:4881 Length:337 Species:Homo sapiens
Sequence 2:NP_476923.1 Gene:dpn / 35800 FlyBaseID:FBgn0010109 Length:435 Species:Drosophila melanogaster


Alignment Length:336 Identity:106/336 - (31%)
Similarity:157/336 - (46%) Gaps:47/336 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    11 ESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLV 75
            ::|::...|....|.|| .|..|..|:::|...|:...||..:.|:|||||.|||:.|:||:.|:
  Fly     4 KNDINSDDDFDCSNGYS-DSYGSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLI 67

Human    76 PTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLS 138
            ..|.:|..:  .|||||:||:|||.||:.:|.........:....:.....||.||..||.||:|
  Fly    68 LEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVS 132

Human   139 SVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAH-HHHPLHPHHWAAAFHHLPAALLQ--PN 200
            .::|:|:.  :|.||.:||:.||...|.....|:.:: :...|.|   |.|....|..|..  |.
  Fly   133 QMDGIDTG--VRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFP---ATAVTAAPTPLFPSLPQ 192

Human   201 GLHASESTPCRLSTTSEVPPA---HGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSA 262
            .|:.:       |.|....||   .|..|:.:.....:.||.||:|||.||  ||...:....:|
  Fly   193 DLNNN-------SRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAP--PPGPFAWPGSAA 248

Human   263 TVHAAAAAATAAAHSFPL---SFAGAFPM--------------LPPNAAAAVAAATAI------S 304
            .|.|..|:|..|:.:.|.   .:..:|.|              ||.|....:...|.:      |
  Fly   249 GVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTS 313

Human   305 PPLS-VSATSS 314
            |||| :|:.||
  Fly   314 PPLSPISSISS 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HEY2NP_036391.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 12/40 (30%)
bHLH-O_HEY2 40..121 CDD:381490 32/82 (39%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 47..116 30/70 (43%)
ORANGE 119..165 CDD:128787 18/45 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..337 5/9 (56%)
YRPW motif 327..330
dpnNP_476923.1 bHLH-O_hairy_like 39..105 CDD:381483 30/65 (46%)
ORANGE 114..158 CDD:128787 18/45 (40%)
Blue background indicates that the domain is not in the aligned region.

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