Protein Alignment LARP4B and Larp4B

DIOPT Version :10

• Sequence 1: XP_016871476.1
• Gene: LARP4B / 23185
• HGNCID: 28987
• Length: 1273
• Species: Homo sapiens
• Sequence 2: NP_647793.1
• Gene: Larp4B / 38399
• FlyBaseID: FBgn0035424
• Length: 1531
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 216/795 - (27%)
• Similarity: 321/795 - (40%)
• Gaps: 214/795 - (26%)

Human   541 HDRDGQFVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGH-----HADRGPQGSDA 600
            |....|.:..|.|:......:.......||...........|.....||     .|..|..|:.:
  Fly   103 HPHQAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTIS 167

Human   601 NG---------DGDQGHE----NAALPDPQESDPA--------DMNALALGPSEYD--------- 635
            .|         :|...:|    |.||...|:....        :.|.:||.|..:.
  Fly   168 GGAVGPSGVVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPV 232

Human   636 ------SLPENSETGGNESQPDSQ-----EDP-------REVLKKTLEFCLSRENLASDMYLISQ 682
                  .||.|   |..:.|..|.     |:|       :::|...||:..||||||:|.||:||
  Fly   233 QVPVPVQLPAN---GSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQ 294

Human   683 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISEST 747
            |||||||||.|||..:.::||:.|::||.||||..|.||||:||.:||||:.|||:||||||.:|
  Fly   295 MDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNT 359

Human   748 PVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKA 812
            |:::|:|||..::.|:.|:||||.|::|:||||::.|||:||||||||||.||||||.||||.|:
  Fly   360 PLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKS 424

Human   813 IAINTF--LPKNGFR---PLDVSLYAQQRYATSFYFPP--------MYSPQQQFPLY------SL 858
            . ||..  :||||:|   |           .|:..|.|        .|:..|| |.|      ::
  Fly   425 F-INRIQAVPKNGYRLTSP-----------PTANVFDPAGAGGATVSYAAAQQ-PRYLYTNGAAI 476

Human   859 ITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSH------ 917
            ..|    |:..|.:|.|: |.|...|..|.       .|.|      :||.:...:.:|
  Fly   477 AAP----ASVQYSNPVLI-PIPQNQFYPGL-------VAGP------WPPGTVAATTAHGQNFYE 523

Human   918 ------LRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAG 976
                  ..:.:|......|..::|                |.|.||..| .:.|....|.....|
  Fly   524 LGGNIFTTNPLPPQPVTAGFAQAP----------------PPTSQAMVT-PKPQGGGRYNNNHRG 571

Human   977 -PGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFP----- 1035
             |..|  |...|.|                     .::::|..|...||.|...|.:..|
  Fly   572 NPNNV--GGANSGP---------------------RAESRSKPPRSTPSASHIQGGNIMPIQITA 613

Human  1036 PLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSP 1100
            |:||...::...::.::.|....:....::.:..          :.::||..|....:||.:.:.
  Fly   614 PIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQQ----------IQQQPSSSAQQQQAATVQMNN 668

Human  1101 SPAHLPDDPK----------------VAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCL 1149
            :..|.|....                ||.....|..|..||:.......:. |:.|....:...|
  Fly   669 TTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQ-QLQGQTQQQHYQL 732

Human  1150 PSCTTAARLWCEQTLRTPAPARFLITSNLELRKPSYAE---ICQRTSKEPPSSPLQPQKEQKPNT 1211
            .|.:.|:..........|||           ::|...:   :.|:|         |||::|:...
  Fly   733 ASSSAASAPQVTYVTTAPAP-----------QQPGQHQHHLVVQQT---------QPQQQQQQQQ 777

Human  1212 VGCGKEEKKLAEPAE 1226
            |...:::.::.|..|
  Fly   778 VVLQQQQVQVQELQE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP4B	XP_016871476.1	LARP_5	657..731	CDD:153405	43/73 (59%)
		RRM_LARP5	736..812	CDD:410105	49/75 (65%)
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	43/73 (59%)
		RRM_LARP4_5_like	348..423	CDD:409864	49/74 (66%)