DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LARP4B and Larp4B

DIOPT Version :9

Sequence 1:	XP_016871476.1	Gene:	LARP4B / 23185	HGNCID:	28987	Length:	1273	Species:	Homo sapiens
Sequence 2:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	216/795 - (27%)
Similarity:	321/795 - (40%)	Gaps:	214/795 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   541 HDRDGQFVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGH-----HADRGPQGSDA 600
            |....|.:..|.|:......:.......||...........|.....||     .|..|..|:.:
  Fly   103 HPHQAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTIS 167

Human   601 NG---------DGDQGHE----NAALPDPQESDPA--------DMNALALGPSEYD--------- 635
            .|         :|...:|    |.||...|:....        :.|.:||.|..:.
  Fly   168 GGAVGPSGVVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPV 232

Human   636 ------SLPENSETGGNESQPDSQ-----EDP-------REVLKKTLEFCLSRENLASDMYLISQ 682
                  .||.|   |..:.|..|.     |:|       :::|...||:..||||||:|.||:||
  Fly   233 QVPVPVQLPAN---GSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQ 294

Human   683 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISEST 747
            |||||||||.|||..:.::||:.|::||.||||..|.||||:||.:||||:.|||:||||||.:|
  Fly   295 MDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNT 359

Human   748 PVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKA 812
            |:::|:|||..::.|:.|:||||.|::|:||||::.|||:||||||||||.||||||.||||.|:
  Fly   360 PLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKS 424

Human   813 IAINTF--LPKNGFR---PLDVSLYAQQRYATSFYFPP--------MYSPQQQFPLY------SL 858
            . ||..  :||||:|   |           .|:..|.|        .|:..|| |.|      ::
  Fly   425 F-INRIQAVPKNGYRLTSP-----------PTANVFDPAGAGGATVSYAAAQQ-PRYLYTNGAAI 476

Human   859 ITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSH------ 917
            ..|    |:..|.:|.|: |.|...|..|.       .|.|      :||.:...:.:|
  Fly   477 AAP----ASVQYSNPVLI-PIPQNQFYPGL-------VAGP------WPPGTVAATTAHGQNFYE 523

Human   918 ------LRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAG 976
                  ..:.:|......|..::|                |.|.||..| .:.|....|.....|
  Fly   524 LGGNIFTTNPLPPQPVTAGFAQAP----------------PPTSQAMVT-PKPQGGGRYNNNHRG 571

Human   977 -PGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFP----- 1035
             |..|  |...|.|                     .::::|..|...||.|...|.:..|
  Fly   572 NPNNV--GGANSGP---------------------RAESRSKPPRSTPSASHIQGGNIMPIQITA 613

Human  1036 PLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSP 1100
            |:||...::...::.::.|....:....::.:..          :.::||..|....:||.:.:.
  Fly   614 PIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQQ----------IQQQPSSSAQQQQAATVQMNN 668

Human  1101 SPAHLPDDPK----------------VAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCL 1149
            :..|.|....                ||.....|..|..||:.......:. |:.|....:...|
  Fly   669 TTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQ-QLQGQTQQQHYQL 732

Human  1150 PSCTTAARLWCEQTLRTPAPARFLITSNLELRKPSYAE---ICQRTSKEPPSSPLQPQKEQKPNT 1211
            .|.:.|:..........|||           ::|...:   :.|:|         |||::|:...
  Fly   733 ASSSAASAPQVTYVTTAPAP-----------QQPGQHQHHLVVQQT---------QPQQQQQQQQ 777

Human  1212 VGCGKEEKKLAEPAE 1226
            |...:::.::.|..|
  Fly   778 VVLQQQQVQVQELQE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LARP4B	XP_016871476.1	None
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	43/73 (59%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	49/74 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151757
Domainoid	1	1.000	72	1.000	Domainoid score	I9336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm40845
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.930