Protein Alignment FOXO3 and foxo

DIOPT Version :8

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 701
• Identity: 230/702 (33%)
• Similarity: 286/702 (41%)
• Gaps: 236/702 (34%)

Human    15 EVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAI 79
            ::.||..||||:|.||.|||..|||....|......|.|
  Fly    27 DLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKA-------------------------- 65

Human    80 GGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGS 144
                             |.:.||||........|.||
  Fly    66 -----------------SNQQLAPGDSQQAIQNANAA---------------------------- 85

Human   145 GQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNS 209
               :|.|||||||||||||||||.||.|:.||||||||||||||:.|||||||||||||||||||
  Fly    86 ---KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNS 147

Human   210 IRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAAL 274
            ||||||||:||||||||||||||||::||: .|.||:.||||.||:.| :|.|.||||.|:..||
  Fly   148 IRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEAL 210

Human   275 QTAP----ESADDSPSQ-----LSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS 330
            :.|.    ..|..|||.     |..:|.||. .|........|||.|.:||||: .||||||.|
  Fly   211 RQAGVVGLNDATPSPSSSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA- 272

Human   331 TELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNIT 395
                  ||               |.|....|...:...:| .|....|     |.|...:.|.:|
  Fly   273 ------QD---------------LEPDWGFPVDYQNTTMT-QAHAQAL-----EELTGTMADELT 310

Human   396 L-------------PPSQPSP--------TGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSS 439
            |             .||||.|        .....|:....||...|     |.|.:|:  ..|.|
  Fly   311 LCNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNG-----PASGYNT--LQPQS 368

Human   440 LNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQN 504
            ...|.:|...:...|                    ..|.||.:.|..|.|.          :..|
  Fly   369 QCLLHRSLNCSCMHN--------------------ARDGLSPNSVTTTMSP----------AYPN 403

Human   505 SRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNM---GLSESSSLG 566
            |                :|:..||                       |:.||:   |.:::::|.
  Fly   404 S----------------EPSSDSL-----------------------NTYSNVVLDGPADTAALM 429

Human   567 SAKHQQQSPVSQSMQTLSDSLSGSSLYSTSAN--LPVMGHEKFPSDLDLDMFN------GSLECD 623
            ..:.|||    |..|.||.||..::..||...  |.|:.:|..|    :|.||      |:|||:
  Fly   430 VQQQQQQ----QQQQQLSASLEDNNCASTLIGQCLEVLNNEAQP----IDEFNLENFPVGNLECN 486

Human   624 MESIIRSELMDADGLDFNFDSLISTQNVVG-----LNVGNFTGAKQASSQS 669
            :|.:::.|:.....||.|........|:|.     |::.|.:.....||.|
  Fly   487 VEELLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSISNISNLSNISSNS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Required for mitochondrial import. {ECO:0000269|PubMed:23283301}	80..108		5/28 (18%)
		FH	157..237	CDD:238016	71/80 (89%)
		Nuclear localization signal. {ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193}	242..259		10/17 (59%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. {ECO:0000269|PubMed:15084260}	300..673		95/408 (23%)
		FOXO_KIX_bdg	433..508	CDD:318810	13/75 (17%)
		FOXO-TAD	606..644	CDD:318811	13/44 (30%)
foxo	NP_001262557.1	FH	95..175	CDD:238016	71/80 (89%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E33208_3BC6N
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3036
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000606
OrthoInspector	1	1.000				T609481
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR45767
Phylome	1	0.910		0.900	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R4575
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	9	8.950