Protein Alignment NLGN1 and Gli

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Alignment Length: 821
• Identity: 225/821 - (27%)
• Similarity: 349/821 - (42%)
• Gaps: 178/821 - (21%)

Human    46 QKLDDV----DPLVATNFGKIRGIKKELN----------------NEILGPVIQFLGVPYAAPPT 90
            |:.|.:    |..|.||:|:::|.|..:.                :.::|....|||:|||.|||
  Fly   124 QRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPT 188

Human    91 GERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLY 155
            .|.||:||.....| .:..|..|.|.|||            ||.:|.    .:..:.|..|||||
  Fly   189 FEGRFKPPRVHRGW-QLLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLY 236

Human   156 LNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASY 220
            ||:|.|.....:.:|.                      |||||||||.::.|..||:.|.:|||:
  Fly   237 LNVYSPKTGAGVAQKY----------------------PVMVYIHGGEFIRGASNLFQGHILASF 279

Human   221 GNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGS 285
            .:|:|:|:|||||.||||||||:.:.||||:||...||||..:||.||.||...||:||.||||:
  Fly   280 YDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGA 344

Human   286 CVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV---SFQPAKYARMLATKVGCNVSDT 347
            ...||.:         :..|:.:.:|.|||||:||:.||:   .::....:|:|...:||::..:
  Fly   345 SAGLLMV---------APQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESS 400

Human   348 VELVECLQK-KPYKELVDQDIQPARYHIAFGPVIDGD-VIPDD-----------------PQILM 393
            .:||.||:. :.:.||.:.:..|......:|||:|.: .:|.|                 |:.|:
  Fly   401 WKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLI 465

Human   394 EQGEF-LNYDIMLGVNQGEGLKFVENIVDSDDGIS------ASDFDFAVSNFVDNLYGYPEGKDV 451
            ..|:| .|...|.||...|...||.    .::.:|      ...||..:...|.. |.|....:.
  Fly   466 RAGKFNRNIQYMTGVTTQEAAFFVA----QNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNG 525

Human   452 LRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQ 516
            :.|.||::||.|.|.:|....|...:.:.:|..:.||......|......|.|.|......:...
  Fly   526 VYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALN 590

Human   517 VPAWADAAHGDEVPYVLGIPMIGPTELFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQ 574
            :|.|....|..|..::.|.|.: .||.||..       ::.||..:|...|..:||||:.|:
  Fly   591 LPQWRKYPHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN--- 651

Human   575 PVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIG--LKPRVKEHYRANKVNLWLELVPHLHNLN 637
            |.||....:|          :.|..|.:..||:|.  ....:..:||..:...|.:.:|.:..:
  Fly   652 PTPQQVLGMH----------FQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGV- 705

Human   638 DISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAV 702
                  ...|..|:|:..:.|..    |:..||                         .|:::|
  Fly   706 ------LVPTYPPTTEYWWEPKE----PLQIAF-------------------------WSMSVA- 734

Human   703 GASLLFLNIL-AFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHEC-- 764
               ..||.:| ....:.::..||:.|   |...:....|......|::...:...|...:|..
  Fly   735 ---CFFLIVLVVICCIMWRNAKRQSD---RFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALR 793

Human   765 --ESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITM 803
              ::|:.:.     ..|...|||.:...|...|.:|:::.|
  Fly   794 SRDNIYEYR-----DSPSTKTLASKAHTDTTSLRSPSSLAM 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	192/627 (31%)
Gli	NP_476602.1	COesterase	137..695	CDD:395084	191/624 (31%)
		PRK13335	818..>918	CDD:139494	3/12 (25%)