Protein Alignment ACSL3 and Acsl

DIOPT Version :10

• Sequence 1: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_001260810.1
• Gene: Acsl / 46068
• FlyBaseID: FBgn0263120
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 716
• Identity: 348/716 - (48%)
• Similarity: 459/716 - (64%)
• Gaps: 38/716 - (5%)

Human    32 LYTILTYIPFYFFSE---SRQEKSNRIKAKPVNSK---------PDS-------------AYRSV 71
            :|.|:| :|.|...:   .|::.|.|:||||:|.|         ||.             .||:.
  Fly    19 VYDIIT-LPVYLVLQKPWKRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNELTYRTT 82

Human    72 N-SLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWL 135
            : ..|....:|....|||:|||.|....:.:||.||||::|:||||||.||::|||..||.|.|.
  Fly    83 DPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWK 147

Human   136 SYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVH 200
            ::.:....|.|||.||:.|||||:.||.||.||||||||||..||.....:||:|||||...:.|
  Fly   148 TFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAH 212

Human   201 ALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDG---KPPTWSEFPKGIIVHTMAAVEAL 262
            .:.|||||.:|||.:|| .|.|.::...|.::.||.::.   |..| :.|.:|:.:.....|...
  Fly   213 CITETEVTTVITSHDLL-PKFKTLLDKCPLVKTIIYIEDQLQKTET-TGFKEGVKILPFNQVVKT 275

Human   263 GAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGY 327
            |..:..|:.|   |...|||:|||||||||.||||::||.|.||.:.|..:.:| :..:||.||:
  Fly   276 GQDSKFEHVP---PKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVP-IYPDDVLIGF 336

Human   328 LPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYK 392
            ||||||.||.||.|||..|..||||:|.||.|.|||||:|.|||.::||||.|.:||.|:|||.|
  Fly   337 LPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISK 401

Human   393 NVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSA 457
            .:.:||:..|:|:::||...|.||::.:.:|..|||.|..||:||..|:||.:|:::.|||||||
  Fly   402 GINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSA 466

Human   458 TTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKP 522
            .|...:..|.|..:.|||||||:....|:.:..|...||.|.||..|:|:|.|||||.|..|:||
  Fly   467 DTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKP 531

Human   523 HPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQ 587
            :|:||:||||:.|:.||||...||..|||| |:||||..||||||.:.||.||||||||||||||
  Fly   532 YPQGEVLIGGECVSQGYYKLPGKTNEDFFE-EDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQ 595

Human   588 AGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGL-KGTWEELCNS 651
            |||||||||||:.||...:::|||.|.:....|.:..|||||..|.|||:|.|| ..::||||:|
  Fly   596 AGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSS 660

Human   652 CEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERM 716
            ..:|..:||.::|.|....|:|:|:|..|.|..|.|:|:.||||.|||||||:::..||.||.||
  Fly   661 PIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRM 725

Human   717 Y 717
            |
  Fly   726 Y 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	346/714 (48%)
Acsl	NP_001260810.1	LC_FACS_euk1	142..714	CDD:341294	295/578 (51%)