Protein Alignment ACSL3 and Fatp3

DIOPT Version :10

• Sequence 1: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_726437.2
• Gene: Fatp3 / 37887
• FlyBaseID: FBgn0034999
• Length: 687
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 130/596 - (21%)
• Similarity: 217/596 - (36%)
• Gaps: 167/596 - (28%)

Human   162 IAIFCETRAE----WMIAAQACFMYNFQLVT--LYATLGGPAIVHALNETEVTNIITSKELLQT- 219
            :|:..|||.|    |:..:|      ..::|  :.:.|.|.:::|::.......:|...|||..
  Fly   166 VALLMETRLEYPCIWLGLSQ------LGVITALINSNLRGESLLHSIKVANAKALIVGSELLDVL 224

Human   220 ---KLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMA-----AVEALGAKASMENQPHSKP 276
               :.|:.:..||..::.          .:..:|:..|.:.     .|.||..:..:|
  Fly   225 VSLREKEQLDEVPIYQYT----------DDEVRGVAGHDLLPGAVDLVTALKTQKKLE------- 272

Human   277 LPSDIA--------VIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHV 333
            |||.:.        :.:||||:|||||..:|::...:....|....: ::..:||....|||.|
  Fly   273 LPSAVCPGEARSKLLYVYTSGTTGLPKAAVITNLRFLFMSAGSYYML-KMSSDDVVYDPLPLYH- 335

Human   334 LELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEI-MDRIYKNVMNK 397
                      :.|..:|.         .:.|..||   |.:|:....|....: .||....|...
  Fly   336 ----------TAGGIVGV---------GNAILNGS---TVVLRKKFSARNFWLDCDRHNCTVAQY 378

Human   398 VSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRF 462
            :.|:..     ::||.:|..:|...                     |:||:...|......:|..
  Fly   379 IGELCR-----YLLATSYSPDQQKH---------------------NLRLMYGNGLRPQIWSQFV 417

Human   463 MNICFCCP-VGQGYGLTESAGAGTISEVWDYNTGRVGA---------------PLVCCEIK---L 508
            ..  |..| :|:.||.||  |...:..:    |.||||               .|.|.|..   |
  Fly   418 RR--FGIPHIGEIYGATE--GNSNLINI----TNRVGAIGFVPVYGSSLYPVQVLRCDEYTGELL 474

Human   509 KNWEEGGYFNTDKPHPRGEILIG------GQSVTMGYY---KNEAKTKADFFEDENGQRWLCTGD 564
            |  :..|:....:|...| :|:|      ..|...||.   .:|.|...:.|  .:|..:..:||
  Fly   475 K--DSKGHCIRCQPGQAG-LLVGKVDARRAVSAFHGYADKGASEQKLLRNVF--TSGDVFFNSGD 534

Human   565 IGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQ 629
            :...:..|.....||..|..:.: ||.|:..:|||.:.|...:::...|         |..:|:
  Fly   535 MVVRDILGYFYFKDRTGDTFRWR-GENVATQEVEAIITNCVGLEDCVVY---------GVQIPH- 588

Human   630 KELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLV 694
                 :..|.|:...       .:.|.:|........:..||..:..|:.|||..|  .|.|.
  Fly   589 -----VEGKAGMAAI-------VDPERKVDMDYLSVVLRGSLPPYARPLFIRLLDE--IPRTA-- 637

Human   695 TDAFKLKRKEL 705
              .||||::||
  Fly   638 --TFKLKKREL 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	130/596 (22%)
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:341262	130/596 (22%)