DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACSL3 and CG9993

DIOPT Version :9

Sequence 1:	NP_001341087.1	Gene:	ACSL3 / 2181	HGNCID:	3570	Length:	720	Species:	Homo sapiens
Sequence 2:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	118/517 - (22%)
Similarity:	195/517 - (37%)	Gaps:	174/517 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   157 KPKTNIAIFCE-TRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTK 220
            |||   .|||: ...:.:.|.::...:..:::.|..||.|           |.||   ::||
  Fly   125 KPK---VIFCDLDNYQTLSAVKSSLKFKTEIILLTGTLPG-----------VRNI---QDLL--- 169

Human   221 LKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIM 285
                            .||        ..|....|:.|.            ||.  ...|.|.|:
  Fly   170 ----------------ADG--------CTGYDEKTLFAC------------PHL--CGDDTAFII 196

Human   286 YTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEED-VYIGYLPLAHVLELSAELVCLSHGCRI 349
            .:||.|||||||..||.:::     .:.:||:|...| |...:.||..:..:...|..|.:|||.
  Fly   197 TSSGVTGLPKGVTRSHRSLL-----NSAKIPQLFTSDTVLFCFSPLYWISCIFTLLASLVNGCRR 256

Human   350 GYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYN 414
            ..::                      :|..:|...::::|      ::||.:.:...::.:||.:
  Fly   257 IITN----------------------RPFSVAYFADLVER------HQVSFVLTVPHHMALLAKS 293

Human   415 YKMEQIS-----------KGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFC 468
            .:.::::           .|...|:   .::|::..|||.|                ||..:
  Fly   294 PERQELAAKMQCVQSFVCSGSKVPM---GIWRQLYELLGAN----------------RFAVL--- 336

Human   469 CPVGQGYGLTESAGAGTISEVWDYNTGRVGAPL-----VCCEIKLKNWEEGGYFNTDKPHPRGEI 528
                  |||||:.|   ||:       .||.||     :...::::..:..|  .:..|:..|:|
  Fly   337 ------YGLTETGG---ISK-------NVGGPLGSEGRLLRNVQVRVVDPHG--QSLGPNQTGQI 383

Human   529 LIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKL------- 586
            |:.......|||.|..:|:.....|   .:||.|||.|.|:.:|||....|..|:.|.
  Fly   384 LVRLNLRWGGYYHNPQETQVTVTPD---GKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYP 445

Human   587 QAGEYVSL---GKVEAALKNLP--LVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKG 643
            :..|.|.|   |..|.|:..:|  :..|:.|.|          ||.|:.||.....:..:||
  Fly   446 KQIEDVILHLPGVHEVAVFGIPDEVSTNLTACA----------VVRNEDELGAQLTEADVKG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	118/517 (23%)
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	118/517 (23%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	118/517 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840