Protein Alignment ACSL3 and hll

DIOPT Version :9

• Sequence 1: NP_001341087.1
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 753
• Identity: 169/753 - (22%)
• Similarity: 304/753 - (40%)
• Gaps: 175/753 - (23%)

Human    63 KPDSAYRSVNSLDGL----------ASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEV 117
            ||.::|||.:..|.:          :..:.|  .|:.:.|..:..|:.:...|
  Fly     5 KPATSYRSTSLHDAVKLRLDEPSSFSQTVPP--QTIPEFFKESCEKYSDLPAL------------ 55

Human   118 QPNGKIFKKVILGQYNW--LSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACF 180
                 :::....|...|  |::.:...|.......|..:|.:.::::.|......||..|.....
  Fly    56 -----VWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGAL 115

Human   181 MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWS 245
            .....:..:|.:....|:.|.|...|.:..:........||:.|...:|||:.:|.:.|....:.
  Fly   116 RAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFV 180

Human   246 EFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDI------------AVIMYTSGSTGLPKGVM 298
            :...|..           :...::.|..|..|..::            |::::|||:.|:||.||
  Fly   181 DHEPGYF-----------SWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVM 234

Human   299 ISHSNIIAGITGMAERIPEL--GEEDVYIGYLPLAHV-LELSAELVCLSH-GCRIGYSSPQTLAD 359
            :||.|::......|..:.::  |:|. ::.||||:|| .::....:.||| ||       .|.||
  Fly   235 LSHDNLVFDTKSAAAHMQDIQVGKES-FVSYLPLSHVAAQIFDVFLGLSHAGC-------VTFAD 291

Human   360 QSSKIKKGSKGDT-SMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQ---I 420
            :.:  .||:...| ...:||.|..||.:.:::.:.::...::...:.|.|...|.....|.   :
  Fly   292 KDA--LKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTL 354

Human   421 SKGRNTPLCDSF-------VFRKVRSLLG-GNIRLLLCGGAPLSATTQRF---MNICFCCPVGQG 474
            ..|::..:..:.       |.:.:|.::| .|.|:...||||.|...::|   ::|.    :|:.
  Fly   355 MAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGEC 415

Human   475 YGLTESAGAGT----ISEVWDYNTGRVGAPLVCCE---IKLKNWEEGGYFNTDKPHPRGEILIGG 532
            ||::|::||.|    ||.:  |:.|:      .||   :|:...:..|         :||||:.|
  Fly   416 YGMSETSGAITLNVDISNL--YSAGQ------ACEGVTLKIHEPDCNG---------QGEILMRG 463

Human   533 QSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKV 597
            :.|.|||.....||:....||    .||.:||:|..:|.|.|.|..|.|:|:....||.:....:
  Fly   464 RLVFMGYLGLPDKTEETVKED----GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHI 524

Human   598 EAAL-KNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKK------------GLKGTWEELC 649
            |..: |.||.|.|:         .:||   .::|.||.|...|            .|:....|..
  Fly   525 EELIKKELPCVSNV---------LLIG---DHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWL 577

Human   650 NSCEME----NEVLKVLSE-------AAISASLE-------------------KFEIP-----VK 679
            ...::.    :|:|.:.::       ||::|:||                   |:.|.     .|
  Fly   578 RDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQK 642

Human   680 IRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMY 717
            ..|....::..||.:....|::|..:...|...|||:|
  Fly   643 FALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	168/751 (22%)
hll	NP_609696.1	AFD_class_I	62..680	CDD:388389	157/675 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810