Protein Alignment ACSL3 and hll

DIOPT Version :10

• Sequence 1: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_609696.1
• Gene: hll / 34822
• FlyBaseID: FBgn0286723
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 753
• Identity: 169/753 - (22%)
• Similarity: 304/753 - (40%)
• Gaps: 175/753 - (23%)

Human    63 KPDSAYRSVNSLDGL----------ASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEV 117
            ||.::|||.:..|.:          :..:.|  .|:.:.|..:..|:.:...|
  Fly     5 KPATSYRSTSLHDAVKLRLDEPSSFSQTVPP--QTIPEFFKESCEKYSDLPAL------------ 55

Human   118 QPNGKIFKKVILGQYNW--LSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACF 180
                 :::....|...|  |::.:...|.......|..:|.:.::::.|......||..|.....
  Fly    56 -----VWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGAL 115

Human   181 MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWS 245
            .....:..:|.:....|:.|.|...|.:..:........||:.|...:|||:.:|.:.|....:.
  Fly   116 RAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFV 180

Human   246 EFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDI------------AVIMYTSGSTGLPKGVM 298
            :...|..           :...::.|..|..|..::            |::::|||:.|:||.||
  Fly   181 DHEPGYF-----------SWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVM 234

Human   299 ISHSNIIAGITGMAERIPEL--GEEDVYIGYLPLAHV-LELSAELVCLSH-GCRIGYSSPQTLAD 359
            :||.|::......|..:.::  |:|. ::.||||:|| .::....:.||| ||       .|.||
  Fly   235 LSHDNLVFDTKSAAAHMQDIQVGKES-FVSYLPLSHVAAQIFDVFLGLSHAGC-------VTFAD 291

Human   360 QSSKIKKGSKGDT-SMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQ---I 420
            :.:  .||:...| ...:||.|..||.:.:::.:.::...::...:.|.|...|.....|.   :
  Fly   292 KDA--LKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTL 354

Human   421 SKGRNTPLCDSF-------VFRKVRSLLG-GNIRLLLCGGAPLSATTQRF---MNICFCCPVGQG 474
            ..|::..:..:.       |.:.:|.::| .|.|:...||||.|...::|   ::|.    :|:.
  Fly   355 MAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIA----LGEC 415

Human   475 YGLTESAGAGT----ISEVWDYNTGRVGAPLVCCE---IKLKNWEEGGYFNTDKPHPRGEILIGG 532
            ||::|::||.|    ||.:  |:.|:      .||   :|:...:..|         :||||:.|
  Fly   416 YGMSETSGAITLNVDISNL--YSAGQ------ACEGVTLKIHEPDCNG---------QGEILMRG 463

Human   533 QSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKV 597
            :.|.|||.....||:....||    .||.:||:|..:|.|.|.|..|.|:|:....||.:....:
  Fly   464 RLVFMGYLGLPDKTEETVKED----GWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHI 524

Human   598 EAAL-KNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKK------------GLKGTWEELC 649
            |..: |.||.|.|:         .:||   .::|.||.|...|            .|:....|..
  Fly   525 EELIKKELPCVSNV---------LLIG---DHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWL 577

Human   650 NSCEME----NEVLKVLSE-------AAISASLE-------------------KFEIP-----VK 679
            ...::.    :|:|.:.::       ||::|:||                   |:.|.     .|
  Fly   578 RDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQK 642

Human   680 IRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMY 717
            ..|....::..||.:....|::|..:...|...|||:|
  Fly   643 FALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	168/751 (22%)
hll	NP_609696.1	Adenylate forming domain, Class I superfamily	62..680	CDD:473059	157/675 (23%)