Protein Alignment FLCN and BHD

DIOPT Version :10

• Sequence 1: NP_001340158.1
• Gene: FLCN / 201163
• HGNCID: 27310
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_648090.1
• Gene: BHD / 38793
• FlyBaseID: FBgn0261111
• Length: 460
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 154/593 - (25%)
• Similarity: 243/593 - (40%)
• Gaps: 152/593 - (25%)

Human     1 MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGDGNEDSPGQGEQAEEEEGGIQMNSRMRAHSPAE 65
            |||::|||||||.|||..:|||:.|.                                  .:..|
  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTLR----------------------------------DTKLE 31

Human    66 GASVESSSPGPKKSDMCEGCR-SLAAGHPGYISHDKETSIKYVSHQHPSHPQLFSIVRQACVRSL 129
            ..|:|..:     ...|..|. |:...:....|.|.|:...:||.:....|::.|:|:||.|.||
  Fly    32 DLSLEQQT-----QKTCSACNYSMGKNNNAIYSRDTESGATFVSTKVAVLPEVASLVKQAAVLSL 91

Human   130 SCECRESAVAALTCWFFCMLQVCPGREGP-IFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIITI 193
            |.....|                  ::|. :||||...|.:.||||.:.|..|||:.:.:|||.:
  Fly    92 SNGTDAS------------------KDGEFVFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVL 138

Human   194 MMDRIYLINSWPFLLGKVRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARS 258
            |.|:.:|:|..|||...::.:..|||..|.|..|.|:....:|.:|::.|  .||..    .:|:
  Fly   139 MKDKYFLLNIKPFLAEHLKKVSSELQAAAKKTKETEEQTYSERQRRLSGA--QFLMP----TSRA 197

Human   259 LTSLTSDDNLWACLHTSFAWLLKACGSR-LTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEA 322
            |..||.:::::|.||:.|:|||.| ||| |||.:..|
  Fly   198 LLELTGEEHIFAQLHSHFSWLLLA-GSRFLTEHVTFG---------------------------- 233

Human   323 EEEEKAPVLPESTEGRELTQGPAE-----SSSLSGCGSWQPRKLPVFKSLRHMRQVLGAPSFRML 382
                ..|.||..:.||.    ||:     ||:|....|.....|..|.||||::.|:....|..:
  Fly   234 ----NLPWLPPQSSGRP----PAQRLTYNSSTLPMIESIDDPDLEEFFSLRHLKSVVRKEEFATV 290

Human   383 AWHVLMGNQVIWKSRDVDLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPHVQIPPH 447
            .:..|.|.:::.:. |..........|:.:||.....::...:|::                  |
  Fly   291 CYCALTGVKIVVRG-DPRKTFRFMVCLKKLLPEPMHNLMRIDAQHQ------------------H 336

Human   448 VLSSEFAVIVEVHAAARSTLHPVGCEDDQSLSKYEFV--------VTSGSPVAADRVGPTILNKI 504
            .:|||:.:|    :.:.....|:.   ..|:.:.:|:        |:...|....|..|.::.|:
  Fly   337 SISSEYKII----SVSNDIAVPMA---SSSVYRIDFLDKHVNGHEVSVKWPGELPRKLPDLMVKL 394

Human   505 EAALTNQNLSVDVVDQCLVCLKEEWMNKVKVL--FKFTKVDSRPKEDTQKLLSILGASEEDNVKL 567
            ..|:..:|.:..|:::....|.|||.|||..|  .|.|.|..       ||..:||....|. .:
  Fly   395 LKAVEEKNFTELVLNKQTKVLIEEWKNKVTCLNHAKSTSVQG-------KLKKVLGVQPHDQ-PI 451

Human   568 LKFWMTGL 575
            :.:|.|.|
  Fly   452 INYWSTHL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLCN	NP_001340158.1	Folliculin	106..283	CDD:463323	59/177 (33%)
		Folliculin_C	362..584	CDD:465236	49/224 (22%)
BHD	NP_648090.1	Folliculin	68..222	CDD:463323	60/178 (34%)
		Folliculin_C	270..459	CDD:465236	48/222 (22%)