Protein Alignment CG45065 and CHDH

DIOPT Version :10

• Sequence 1: NP_001285251.1
• Gene: CG45065 / 19835504
• FlyBaseID: FBgn0266435
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_060867.2
• Gene: CHDH / 55349
• HGNCID: 24288
• Length: 594
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 219/586 - (37%)
• Similarity: 306/586 - (52%)
• Gaps: 76/586 - (12%)

  Fly    41 RRQYDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDETEISDVPALAGYLQLTELDWKYQTTP 105
            |.:|.:||:|.||||.|:|.||:|.....|||||||..:       .|||..:|:   ||.....
Human    38 RDEYSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPKD-------VLAGSKRLS---WKIHMPA 92

  Fly   106 SSTRQYC-------------QAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYNHWASLGNPG 157
            :.....|             :.:.|...:||||:|.||||.|||||||||...||..|...|..|
Human    93 ALVANLCDDRYNWCYHTEVQRGLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARG 157

  Fly   158 WDYDSMLKYFLKSEDVRNPYLAKTPYHETGGYLTVQEAPWRTPLSIAFLQAGIEMGYE-NRDING 221
            |||...|.||.|::   ...|..:.|....|.|.|.......||..|||:|..:.||. ..|:||
Human   158 WDYAHCLPYFRKAQ---GHELGASRYRGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNG 219

  Fly   222 AQQTGFMLTQSTIRRGARCSTGKAFIRPVRQRKNFDVLLHAEA----TRILFDKQKRAIGVEYMR 282
            .||.||.....||..|.|.|...|::.|...|.|    |.|||    :|:||: ..||:||||::
Human   220 FQQEGFGWMDMTIHEGKRWSAACAYLHPALSRTN----LKAEAETLVSRVLFE-GTRAVGVEYVK 279

  Fly   283 GGRKNVVFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVISDLP-VGNNMQDHVGLGGLT 346
            .|:.:..:..:|||.|.||:|:|:||||||:|.|:.|::..|||:..|| ||.|:|||:.:
Human   280 NGQSHRAYASKEVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEI---- 340

  Fly   347 FVVDA---PLTV--TRNRFQTIPVSMEYILRERGPMTFSGVEGVAFLNTKYQDPSVDWPDVQFHF 406
            ::..|   |:|:  .:...:.:.:.:|::.:..|....:.:|...|:.::   |.|..||:||||
Human   341 YIQQACTRPITLHSAQKPLRKVCIGLEWLWKFTGEGATAHLETGGFIRSQ---PGVPHPDIQFHF 402

  Fly   407 CPSSINSDGGEQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTGWVRLNSRNPQHQPKI 471
            .||.:...|                  ..|.| .|.:.:....:|..|.||::|.|.|||..|.|
Human   403 LPSQVIDHG------------------RVPTQ-QEAYQVHVGPMRGTSVGWLKLRSANPQDHPVI 448

  Fly   472 IPNYFAHQEDIDVLVEGIKLAINVSNTQAFQRF-GSRLHNIPLPGCRHLPFQSNEYWACCIKEFT 535
            .|||.:.:.||:.....:||...:...:|...| |..|.    || .|:  ||::.....::...
Human   449 QPNYLSTETDIEDFRLCVKLTREIFAQEALAPFRGKELQ----PG-SHI--QSDKEIDAFVRAKA 506

  Fly   536 FTIYHPAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPNAPVIAIGEKASDLI 600
            .:.|||:.||:||...|.||||||:.||.||..:|||||||||::|:||.|||.|.|.|||:|:|
Human   507 DSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADII 571

  Fly   601 K 601
            |
Human   572 K 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45065	NP_001285251.1	BetA	43..603	CDD:441878	218/584 (37%)
CHDH	NP_060867.2	PRK02106	40..594	CDD:235000	218/584 (37%)