Protein Alignment Pax6 and toe

DIOPT Version :10

• Sequence 1: NP_038655.1
• Gene: Pax6 / 18508
• MGIID: 97490
• Length: 436
• Species: Mus musculus
• Sequence 2: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 161/522 - (30%)
• Similarity: 226/522 - (43%)
• Gaps: 178/522 - (34%)

Mouse    11 LGGVFVNGRPLPD--------------STRQKIVELAHSGARPCDISRILQTHADAKVQVLDNEN 61
            |||:|..|.....              :::.:::||:..|.|..|:::.:.:
  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLS------------- 155

Mouse    62 VSNGCVSKILGRYYETGSIRPRA-IGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGV 125
             ..|.|||:|      |::||.. ||||||:||||.|||||.|||||.|:|||||||:||::|||
  Fly   156 -QQGAVSKLL------GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGV 213

Mouse   126 CTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWG-----TRPGWYPGTSVP-- 183
            |||...||||||||:|||.|:|:    |...:       .:..|:|     |.|  :|.||.|
  Fly   214 CTNATAPSVSSINRILRNRAAER----AAAEF-------ARAASYGYAIHPTHP--HPYTSFPTW 265

Mouse   184 -----------------GQPTQDGCQQQEGG--------------------------GENTNSIS 205
                             |.|...|...|.||                          |.||||.|
  Fly   266 PAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGS 330

Mouse   206 SNGEDSDEAQMRLQL------------------------------------KRKLQRNRTSFTQE 234
            ..| ||.....||.|                                    :.|.:||||:|:.|
  Fly   331 GCG-DSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPE 394

Mouse   235 QIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHI 299
            |::.|||||:::|||.|..||:|||:..|.|||:|||||||||||||.:::...:::.|
  Fly   395 QLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDS------ 453

Mouse   300 PISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMP-SFTMANNLPMQPPVPS 363
            |.:||..|.:..|:..|.:|:                        |:| ...:..:...:.|.|.
  Fly   454 PSTSSSPTPLVNPVVSPVSPI------------------------PVPVPVAVPESGQQKQPYPY 494

Mouse   364 QTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSG-------TTSTGLISPGVSVPVQV 421
            .||: .|...:|.| |.:..:|..|   .:.|:|:....|.       ..:....||..|.|:.:
  Fly   495 STSN-MCNTSSSSS-NSQPCNTINP---GSKMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSM 554

Mouse   422 PG 423
            .|
  Fly   555 GG 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax6	NP_038655.1	PAX	4..142	CDD:128645	62/145 (43%)
		Homeodomain	226..281	CDD:459649	36/54 (67%)
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197	57/115 (50%)
		Homeodomain	385..441	CDD:459649	36/55 (65%)