DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARID3A and osa

DIOPT Version :9

Sequence 1:	NP_005215.1	Gene:	ARID3A / 1820	HGNCID:	3031	Length:	593	Species:	Homo sapiens
Sequence 2:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	143/589 - (24%)
Similarity:	201/589 - (34%)	Gaps:	184/589 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    28 PPDPPAAPPGRARAAPDEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPG--SEE 90
            ||.....|.|.....|.....|:|..:|..|..            |..|| ||.|.|.|.  |::
  Fly   809 PPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQPQ------------GQGAS-GGPESGGPEHISQD 860

Human    91 EDAAREGTPGSPGRG------REGPGEEHFEDMASDEDMKPKWEEEEMEEDLGED------EEEE 143
            ...:..|..|:.|..      ..||      |..|.:::..:..........|||      :..:
  Fly   861 NGISSSGPTGAAGMHAVTSVVTTGP------DGTSMDEVSQQSTLSNASAASGEDPQCTTPKSRK 919

Human   144 EEDYEDEEEEEDEEGLGPP-------------GPA---SLGTTALFPRKAQPPQAFRGDGVPRVL 192
            .:.|       .:..|.||             ||.   .:.:...:||.|..||.|.
  Fly   920 NDPY-------SQSHLAPPSTSPHPVVMHPGGGPGEEYDMSSPPNWPRPAGSPQVFN-------- 969

Human   193 GGQERPGPGPAHPGGAAHVAPQLQPPDHGDWT---YEEQFKQLYELDGDPKRKEFLDDLFSFMQK 254
                             || |..|.|.....|   ..:...:|||:|.:|.|:.:||.|.:||::
  Fly   970 -----------------HV-PVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRRGWLDKLRAFMEE 1016

Human   255 RGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYM 319
            |.||:...|.::||.|||:.||:.|.|:||.|||...|.|::|...|.:..| :|||:|||..|.
  Fly  1017 RRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGAS-SSAAYTLRKHYT 1080

Human   320 KYLYPYECE-KRGLSNPNELQAAIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLA 383
            |.|..:||. .||..:|..:...:::    |.::....:....||||.|       |...:....
  Fly  1081 KNLLTFECHFDRGDIDPLPIIQQVEA----GSKKKTAKAASVPSPGGGH-------LDAGTTNST 1134

Human   384 ASTNGSSITPAPKIKKEEDSAIPITVPGRLP-VSLAGHPVVAAQAAAVQAAAAQA--AVAAQAAA 445
            .|:|.....|||              ||..| .::.|:|.....:....|:..|.  |.|.|
  Fly  1135 GSSNSQDSFPAP--------------PGSAPNAAIDGYPGYPGGSPYPVASGPQPDYATAGQ--- 1182

Human   446 LEQLREKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSIRINSQASESRQDSAVNL 510
                                        |||...||              |.|.......:||
  Fly  1183 ----------------------------MQRPPSQN--------------NPQTPHPGAAAAV-- 1203

Human   511 TGTNGSNSISMSVEINGIMYTGVLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGGNTGTSGGQA 575
              ..|.| ||:|                   .|...|...|||.|..:....|:|...|.:.|.|
  Fly  1204 --AAGDN-ISVS-------------------NPFEDPIAAGGGPGSGTGPGPGQGPGPGAASGGA 1246

Human   576 GPAG 579
            |..|
  Fly  1247 GAVG 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARID3A	NP_005215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..222		45/223 (20%)
		Acidic	119..156		5/42 (12%)
		BRIGHT	239..331	CDD:128777	41/92 (45%)
		Important for nuclear localization. /evidence=ECO:0000250	445..488		5/42 (12%)
		Homodimerization	490..513		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..516		3/18 (17%)
		Important for cytoplasmic localization. /evidence=ECO:0000250	537..557		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..593		13/41 (32%)
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	41/91 (45%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.900