Protein Alignment myo-2 and zip

DIOPT Version :9

• Sequence 1: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0265434
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1990
• Identity: 710/1990 - (35%)
• Similarity: 1121/1990 - (56%)
• Gaps: 83/1990 - (4%)

 Worm     5 NDPGWKYLRRSREEMLQDQSRA-YDSKKNVWIPDSEDGYIEGVITKTAGDNVTVSIGQ-GAEKTV 67
            |||..|||...|.:.....::| :..|:.||:|....|::...|.:..||.|.|.:.: |....:
  Fly    53 NDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMI 117

 Worm    68 KKDVVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTD 132
            .:|.:|:||||||:|.|||:.||.||:||||:|:|.||.:.||||||||||||:||||:|||||:
  Fly   118 LRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTE 182

 Worm   133 SVARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAA 197
            .:...:.|.:|.|:|||:||::|.||||||.:.|:||:|.||||||||||||||||.:.|.|.|:
  Fly   183 KIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAAS 247

 Worm   198 QQETFGA--------------------KKAA---------------TEEDKNKKKVTLEDQIVQT 227
            :.:..||                    |..|               .|.:.|.::..||.|::|.
  Fly   248 KPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQA 312

 Worm   228 NPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCYHIFYQ 292
            ||:||||||||||:|:|||||||||||:|...|.::..:||.|||||||.||||..||.:|||||
  Fly   313 NPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQ 377

 Worm   293 VFSDYLPNLKKDLLLNKPVKDYWFIAQAELIIDGINDKEEHQLTDEAFDILKFTPTEKMECYRLV 357
            :.:...|..::..:|: .||.|.|::...|.:.|::|..|.|.|.::.:|:..|..:....:|:|
  Fly   378 LLAGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIV 441

 Worm   358 AAMMHMGNMKFKQRPREEQAE-PDGTDDAERAAKCFGIDSEEFLKALTRPRVKVGNEWVNKGQNI 421
            :|::..|:|||:|....:||. ||.| .|::.|...|:...:..:|...||:|||.::|.|.|..
  Fly   442 SAVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTK 505

 Worm   422 EQVNWAVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIGVLDIAGFEIFDFNSFEQLWINFV 486
            |||.:||.|:||..|.|:|.|||.:.|::||:.......|||:||:||||||:.||||||.||:.
  Fly   506 EQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYT 570

 Worm   487 NEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIEKPLGIIAMLDEECIVPKATDL 551
            ||||||.|||.||:||||||.||||:|.|||||||||..|:||:||.||:|:|||||..|||||.
  Fly   571 NEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDK 635

 Worm   552 TLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMRHYAGTVRYNCLNWLEKNKDPLNDTVVTVMK 616
            |...||:..| ..||.|.|    ...:..|.||:.||||.|.|:...||.||.||||:.:|::::
  Fly   636 TFVDKLVSAH-SMHPKFMK----TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQ 695

 Worm   617 ASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYRESLNKLMTMLHSTHPH 681
            .|:: ..:|.:|:|......|..|......||:.  :.|.|.|||.||:|.|.|||..|.:|:|:
  Fly   696 GSQD-PFVVNIWKDAEIVGMAQQALTDTQFGART--RKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757

 Worm   682 FIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYALLAADESIIG 746
            |:||||||.:|.:|.|||.|||:||.||||||||||||:|||||....:|.|||.||..:....|
  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG 822

 Worm   747 KTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQSLAQLITGLQAQIRWY 811
            ..|.||....|:..|    :|:...:|||.:|:||:||::||||:.||..::.||...||..|.:
  Fly   823 FMDGKKACEKMIQAL----ELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGF 883

 Worm   812 YQTIERKRRVEKITALKIIQRNIRSWAELRTWVWFKLYGKVKPLVNSGKIEAQYEKLQETVATLK 876
            ......::|::::.|::|||||..::.:||.|.|::||.|||||:   ::..|.|||
  Fly   884 LARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLL---EVTKQEEKL-------- 937

 Worm   877 DTVVQEEEKKRQLQEGAERLNKETAD--------------LLAQLEASKGSTREVEERMTAMNEQ 927
               ||:|::.:|::|..:.|.|.|.:              |..||:|......|.||..:.:..:
  Fly   938 ---VQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMAR 999

 Worm   928 KVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAKEHQIR 992
            |..||..:.:...::|.||.|.:.:..:||.:|....||::..::.:.:.:|::.||...:.:|:
  Fly  1000 KQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIK 1064

 Worm   993 ALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQTMERE 1057
            ..::::...|:...||.||:|..||:...|::.|...||:.....|||||...::.:.|:.:.::
  Fly  1065 KYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKD 1129

 Worm  1058 KRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRKETELHTLGMKLEDEQAAVAKLQK 1122
            ::.|.:.|::|||.|.|:...:|.|.|......:.:..|.::|.||....:::::|.|..|..||
  Fly  1130 QQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQK 1194

 Worm  1123 GIQQDEARVKDLHDQLADEKDARQRADRSRADQQAEYDELTEQLEDQARATAAQIELGKKKDAEL 1187
            ..::.|:::.::.:.|..||.||.:|::.|.|...|.:.|..:|.|....||||.||..|::.||
  Fly  1195 AQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQEL 1259

 Worm  1188 TKLRRDLEESGLKFGEQLTVLKKKGSDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDESSAALD 1252
            ..|::.|||..:.....|..::.|.|..:..::||:|.|:|.|..:||.||.::.|..:.:..|.
  Fly  1260 ATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELR 1324

 Worm  1253 QEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQDFVSSKGRLNSENSDLARQVEELEAKIQAA 1317
            .....|.:.:|..|..|.::.||::|..|..|...:......:|..|..::..|:||.|.|..||
  Fly  1325 SVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAA 1389

 Worm  1318 NRLKLQFSNELDHAKRQAEEESRERQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASV 1382
            .:......::|..|::..|||:|::..||:..:.:..|.|.|:|.:|::...|....|:|::.:.
  Fly  1390 VKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTT 1454

 Worm  1383 ELDQWRTKFETEGLIGADEFDEVKKRQNQKTSEIQDALDACNAKIVALENARSRLTAEADANRLE 1447
            ::.:.:.|.|.:..: |.|.:|.|||.|:....::..:....|:...|:.::.::.:|.:...:|
  Fly  1455 QMQEIKKKAEEDADL-AKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIE 1518

 Worm  1448 AEHHAQAVSSLEKKQKAFDKVIDEWKKKVDDLYLELDGAQRDARQLSGEAHKLRGQHDTLADQVE 1512
            .|.....|..||||||.|||::.|.|...:.:..|.|.|:|:||:...:...:..:.|...|::|
  Fly  1519 LEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIE 1583

 Worm  1513 GLRRENKSLSDETRDLTESLSEGGRATHALSKNLRRLEMEKEELQRGLDEAEAALESEESKALRC 1577
            .|..:.|:|.:|..||..:.....:..|.|.|..|.||.:..||:...:|.|..|:..|...||.
  Fly  1584 DLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRL 1648

 Worm  1578 QIEVSQIRAEIEKRIAEKEEEFENHRKVHQQTIDSIQATLDSETKAKSELFRVKKKLEADINELE 1642
            ::.:..:|::.|:.:..|||..|..|:...:.:..::..||.|.|.::.....|||||.|:.|:|
  Fly  1649 EVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIE 1713

 Worm  1643 IALDHANKANEDAQKNIRRYLDQIRELQQTVDEEQKRREEFREHLLAAERKLAVAKQEQEELIVK 1707
            ..::..||..|||.|:.::...|:::..:..:|.:..:||.:.....||||:...:.|..:|...
  Fly  1714 TTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTED 1778

 Worm  1708 LEALERARRVVESSVKE-HQEHNNELNSQNVALAAAKSQLDNEIALLNSDIAEAHTELSASEDRG 1771
            |.:.|||||..|:...| .:|..|..|..:: :...|.:|:..||.|..::.|..:......||.
  Fly  1779 LASSERARRAAETERDELAEEIANNANKGSL-MIDEKRRLEARIATLEEELEEEQSNSEVLLDRS 1842

 Worm  1772 RRAASDAAKLAEDLRHEQEQSQQLERFKKQLESAVKDLQERADAAEAAVMKGGAKAIQKAEQRLK 1836
            |:|.....:|..:|.:|:..||:.|..:..||...|:|:.:....|.|........|...|.::.
  Fly  1843 RKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIA 1907

 Worm  1837 AFQSDLETESRRAGEASKTLARADRKVREFEFQVAEDKKNYDKLQELVEKLTAKLKLQKKQLEEA 1901
            ..:..||.|.:......|...:.|:|::|....:.:::::.|:.:|.::||.:::||.|:.|:|.
  Fly  1908 NLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDET 1972

 Worm  1902 EEQANSHLSKYRTVQLSLETAEERADSAEQCLVRIRSRTR 1941
            ||:.....::.|..|...|...|..::..:.:..::::.|
  Fly  1973 EEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo-2	NP_510092.2	Myosin_N	31..68	CDD:280832	10/37 (27%)
		Myosin_head	83..782	CDD:278492	355/734 (48%)
		MYSc_class_II	95..782	CDD:276951	348/722 (48%)
		Myosin_tail_1	876..1939	CDD:279860	290/1077 (27%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	355/734 (48%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	348/722 (48%)
		Myosin_tail_1	931..2011	CDD:279860	294/1092 (27%)
		Prefoldin	1431..1515	CDD:298833	18/84 (21%)
		FAM76	<1847..1926	CDD:292665	17/78 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720