DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mpo and cd

DIOPT Version :9

Sequence 1:	NP_034954.2	Gene:	Mpo / 17523	MGIID:	97137	Length:	718	Species:	Mus musculus
Sequence 2:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	244/730 - (33%)
Similarity:	341/730 - (46%)	Gaps:	144/730 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    37 LSCMEEAKQLVDRAYKERRESIKRSLQSGSASPTELLFYFKQPVAGTRTAVRAADYLHVALDLLK 101
            ||...||::|..|.|.|.:.:|                                       |:.|
  Fly   156 LSTNPEARKLARRGYVENQATI---------------------------------------DIAK 181

Mouse   102 RKLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDV-------RVTCPPNDKYRTITGHCNNRRS 159
            |         ||.|.  .|.:.|:     |...:.|       |:.|..|.:||..||.|||::.
  Fly   182 R---------FNYTK--QPGRSNI-----GWGPKIVLPDPTVLRLECDFNARYRRSTGVCNNKQH 230

Mouse   160 P-TLGASNRAFVRWLPAEYEDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTKDQERA 223
            | |.|||...:.|.:..:|.||::     .|.|:.:| ::|.|||||..|.|   .....|....
  Fly   231 PRTYGASMVPYRRMVSPDYADGIA-----APRVSHHG-RLPPARQVSLKIHR---SSYETDSNFT 286

Mouse   224 LMFMQWGQFLDHDITLTPEPATRFSFFTGLNCET--SCL-----QQPPCFPLKIPPNDPRIKNQK 281
            :|...:|||:|||||.|       |..|....|:  .|:     |.|.|:|:.|.|:||..|...
  Fly   287 VMLAVFGQFMDHDITAT-------SLTTSQEGESIDCCVAATREQHPECYPVDILPDDPYYKQYN 344

Mouse   282 -DCIPFFRSCPACTRNNITIRNQINALTSFVDASGVYGSEDPLARKLRNLTNQLGLLAINTRFQD 345
             .|:.|.||.||.| .....|.|:|..|:|:|||.|||:.:....:||:..|.    ::.....|
  Fly   345 ISCMNFVRSAPAPT-GRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFING----SLRMFVTD 404

Mouse   346 NGRALMPFDSLHDDPCLLTNR--SARIP--CFLAGDMRSSEMPELTSMHTLFVREHNRLATQLKR 406
            :||.|:|..|...|.|   ||  ..|:.  ||.:||.|::|...|||||.|:.|.||.||.||:.
  Fly   405 DGRQLLPISSNPADGC---NRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQE 466

Mouse   407 LNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLG----------PAAMKKYLPQYRSYNDSVD 461
            .||.|..|:||||||||:||.:..|||.::||::||          ||......|.  :|:..||
  Fly   467 QNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPD--TYDPEVD 529

Mouse   462 PRIANVF-TNAFRYGHTLIQPFMFRLNNQYRPTGPNPRVPLSKVFFASWRVVLEGGIDPILRGLM 525
            |.|||.| ..|||:.|||: |.:|.::   |.......:.|.|:.|..:.:..|.|||..|....
  Fly   530 PSIANCFAAAAFRFAHTLL-PGLFNIS---RDNSTPEAIELHKMLFNPFSLWAEHGIDHALMTAA 590

Mouse   526 ATPAKLNRQNQIVVD-----EIRERLFE-----QVMRIGLDLPALNMQRSRDHGLPGYNAWRRFC 580
            .||.       :.||     |:.::|||     :|...||||.:||:||.||||:|.|..:||.|
  Fly   591 NTPV-------MQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHC 648

Mouse   581 GLPQPSTVGELGTVLKN--LELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQF 643
            .||...|..|:...:.|  |:..|::   |.:|.::|::.|.:|||.......|.||:|::..||
  Fly   649 RLPTVDTWEEMSQAIDNATLDSIRQI---YESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQF 710

Mouse   644 RKLRDGDRFWWE---NPGVFSKQQRQALASISLPRIICDNT-GITTVSKNNIFMSNTYPRDFVSC 704
            .:|:.||..|:|   .|..|:|.|...:...||..|||.|: |||.|.::.:..........|.|
  Fly   711 LRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPHVDC 775

Mouse   705 NTLP--KLNLTSWKE 717
            ..|.  ..|...|.|
  Fly   776 QDLEGFHFNFEPWSE 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpo	NP_034954.2	An_peroxidase	147..685	CDD:281139	214/577 (37%)
Mpo	NP_034954.2	myeloperoxidase_like	289..702	CDD:188656	162/443 (37%)
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	213/576 (37%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	153/408 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870