DRSC/TRiP Functional Genomics Resources

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Protein Alignment DAPK1 and bt

DIOPT Version :10

Sequence 1:NP_004929.2 Gene:DAPK1 / 1612 HGNCID:2674 Length:1430 Species:Homo sapiens
Sequence 2:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster


Alignment Length:585 Identity:186/585 - (31%)
Similarity:275/585 - (47%) Gaps:110/585 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70
            |::|.|.||..||:|:|.|.||.:|||:|||..:|||||....:      |.::.|.||:.|:.:
  Fly  7982 QQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHS------VEKDLIRREIDIMNQ 8040

Human    71 IQHPNVITLHEVYENKTDVILILELVAGGELFD-FLAEKESLTEEEATEFLKQILNGVYYLHSLQ 134
            :.|..:|.||:.:|:..::|||||.::|||||: ..||...:||.|...:::||..|:.::|...
  Fly  8041 LHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQN 8105

Human   135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEAD 199
            |.|.|:||||||...|:  ...:|:||||||.::|.....|...||.||.||||||.||:|...|
  Fly  8106 IIHLDIKPENIMCQTRS--STNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTD 8168

Human   200 MWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRM 264
            ||:.||::|:||||.|||.||...:||.||.|.:::|:.|.|...|..||||||:|||::.:|||
  Fly  8169 MWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRM 8233

Human   265 TIQDSLQHPWIKPKDT--QQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSR-SFLSRS 326
            |..:.|.|||:....:  :|.::|.......||.     |:|::...|.:....|||. |.|.:.
  Fly  8234 TAHECLLHPWLTGDHSAMKQEINRDRYLAYREKL-----RRKYEDFERFLLPIGRLSEYSSLRKL 8293

Human   327 NMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKH-------GTPPLL 384
            .|...:..|.:.:......:.:|.       |..|..      |: .|..|.       .||.|.
  Fly  8294 LMEKYKIHDAVFDRRQAAPRFVIR-------PSSQFC------YE-GQSVKFYCRCIAIATPTLT 8344

Human   385 IAAGCGNIQILQLL--IKRG---------SRIDVQDKGGSNAVYWAARH-GHVDTLKFLSENKCP 437
            .:.  .||::.|.:  :||.         :|:.:.|:|  ..:..|..| |..:.:.||:....|
  Fly  8345 WSH--NNIELRQSVKFMKRYVGDDYYFIINRVKLDDRG--EYIIRAENHYGSREEVVFLNVQPLP 8405

Human   438 ------------------------LDVKDKSGEMALHVAARYGHA-DVAQLLCSFGSN--PNI-- 473
                                    .:..:.:......:..|...| |..:|||.....  ||:  
  Fly  8406 KEQPRYRTESTPVRRREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKPVPNVRW 8470

Human   474 -QDKEEETPLHCAAWH-----------------GYYSVAKALC----EAGCNVNIKNREGE--TP 514
             :|..|.:....|..|                 |.||.....|    |..|.|.:   |||  ||
  Fly  8471 YKDGRELSKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIV---EGEWVTP 8532

Human   515  514
              Fly  8533  8532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DAPK1NP_004929.2 STKc_DAPK1 7..275 CDD:271096 123/268 (46%)
Calmodulin-binding 267..334 17/69 (25%)
Autoinhibitory domain. /evidence=ECO:0000250 292..301 2/8 (25%)
Ank_2 <338..409 CDD:463710 15/88 (17%)
ANK repeat 378..409 CDD:293786 9/48 (19%)
ANK 1 378..407 9/46 (20%)
ANKYR 392..668 CDD:440430 37/188 (20%)
ANK 2 411..440 7/53 (13%)
ANK repeat 412..442 CDD:293786 6/54 (11%)
ANK repeat 444..475 CDD:293786 8/36 (22%)
ANK 3 444..473 7/31 (23%)
ANK repeat 477..508 CDD:293786 10/51 (20%)
ANK 4 477..506 10/49 (20%)
ANK repeat 510..541 CDD:293786 5/7 (71%)
ANK 5 510..539 5/7 (71%)
ANK repeat 543..574 CDD:293786
ANK 6 543..572
ANK repeat 576..607 CDD:293786
ANK 7 576..605
ANK repeat 609..638 CDD:293786
ANK 8 609..638
ANK 9 875..904
ANK 10 1162..1196
Death_DAPK1 1308..1393 CDD:260052
btNP_001162825.1 Ig 9..101 CDD:472250
Ig strand B 26..30 CDD:409353
Ig strand C 39..43 CDD:409353
Ig strand E 69..73 CDD:409353
Ig strand F 83..88 CDD:409353
Ig strand G 96..99 CDD:409353
I-set 119..210 CDD:400151
Ig strand B 136..140 CDD:409353
Ig strand C 149..153 CDD:409353
Ig strand E 174..182 CDD:409353
Ig strand F 192..197 CDD:409353
Ig strand G 205..208 CDD:409353
Ig 228..320 CDD:472250
Ig strand B 245..249 CDD:409353
Ig strand C 258..262 CDD:409353
Ig strand E 286..292 CDD:409353
Ig strand F 302..307 CDD:409353
Ig strand G 317..320 CDD:409353
Ig 335..425 CDD:472250
Ig strand B 350..354 CDD:409353
Ig strand C 363..367 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 420..423 CDD:409353
Ig 438..532 CDD:472250
Ig strand B 455..459 CDD:409353
Ig strand C 468..472 CDD:409353
Ig strand E 498..502 CDD:409353
Ig strand F 512..517 CDD:409353
Ig strand G 525..528 CDD:409353
Ig 545..636 CDD:472250
Ig strand B 560..564 CDD:409353
Ig strand C 573..577 CDD:409353
Ig strand E 599..606 CDD:409353
Ig strand F 616..621 CDD:409353
Ig strand G 629..632 CDD:409353
Ig 656..726 CDD:472250
Ig strand B 657..661 CDD:409353
Ig strand C 670..674 CDD:409353
Ig strand E 700..704 CDD:409353
Ig strand F 714..719 CDD:409353
Ig strand G 728..731 CDD:409353
Ig 746..835 CDD:472250
Ig strand C 777..781 CDD:409353
Ig strand E 802..806 CDD:409353
Ig strand F 816..821 CDD:409353
Ig 1508..1588 CDD:472250
Ig strand B 1514..1518 CDD:409353
Ig strand C 1527..1531 CDD:409353
Ig strand E 1554..1558 CDD:409353
Ig strand F 1568..1573 CDD:409353
Ig strand G 1581..1584 CDD:409353
Ig 1639..1724 CDD:472250
IG_like 1750..1821 CDD:214653
Ig strand B 1750..1753 CDD:409353
Ig strand C 1761..1765 CDD:409353
Ig strand E 1788..1792 CDD:409353
Ig strand F 1802..1806 CDD:409353
Ig 1826..1909 CDD:472250
Ig strand B 1842..1846 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1879..1883 CDD:409353
Ig 1914..1998 CDD:472250
Ig 2020..2095 CDD:472250
Ig strand B 2021..2025 CDD:409353
Ig strand C 2038..2042 CDD:409353
Ig strand E 2062..2066 CDD:409353
Ig strand F 2076..2081 CDD:409353
Ig strand G 2089..2092 CDD:409353
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
Ig 2314..2395 CDD:472250
Ig strand B 2322..2326 CDD:409353
Ig strand C 2335..2339 CDD:409353
Ig strand E 2361..2365 CDD:409353
Ig strand F 2375..2380 CDD:409353
FN3 <2376..2753 CDD:442628
Ig strand G 2388..2391 CDD:409353
FN3 2501..2590 CDD:238020
FN3 <2673..>2891 CDD:442628
Ig 2902..2995 CDD:472250
Ig strand B 2920..2924 CDD:409353
Ig strand C 2933..2937 CDD:409353
FN3 <2957..>3191 CDD:442628
Ig strand E 2961..2965 CDD:409353
Ig strand F 2975..2980 CDD:409353
Ig strand G 2988..2991 CDD:409353
FN3 2999..3088 CDD:238020
Ig 3212..3292 CDD:472250
Ig strand B 3220..3224 CDD:409353
Ig strand C 3233..3237 CDD:409353
Ig strand E 3258..3262 CDD:409353
Ig strand F 3272..3277 CDD:409353
Ig strand G 3285..3288 CDD:409353
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:400151
Ig strand B 3517..3521 CDD:409353
Ig strand C 3530..3534 CDD:409353
Ig strand E 3556..3560 CDD:409353
Ig strand F 3570..3575 CDD:409353
Ig strand G 3583..3586 CDD:409353
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:400151
Ig strand B 3813..3817 CDD:409353
Ig strand C 3826..3830 CDD:409353
Ig strand E 3851..3855 CDD:409353
Ig strand F 3865..3870 CDD:409353
FN3 <3866..4181 CDD:442628
Ig strand G 3878..3881 CDD:409353
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
FN3 4356..4776 CDD:442628
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
Ig_3 4978..5056 CDD:464046
FN3 <5021..>5264 CDD:442628
FN3 5073..5166 CDD:238020
Ig 5286..5366 CDD:472250
Ig strand B 5294..5298 CDD:409353
Ig strand C 5307..5311 CDD:409353
Ig strand E 5332..5336 CDD:409353
Ig strand F 5346..5351 CDD:409353
Ig strand G 5359..5362 CDD:409353
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:472250
Ig strand B 5588..5592 CDD:409353
Ig strand C 5601..5605 CDD:409353
Ig strand E 5626..5630 CDD:409353
Ig strand F 5640..5645 CDD:409353
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
Ig 5874..5954 CDD:472250
Ig strand B 5882..5886 CDD:409353
Ig strand C 5895..5899 CDD:409353
Ig strand E 5920..5924 CDD:409353
Ig strand F 5934..5939 CDD:409353
Ig strand G 5947..5950 CDD:409353
FN3 <5972..>6384 CDD:442628
Ig_Titin_like 6174..6255 CDD:409406
Ig strand A 6174..6178 CDD:409406
Ig strand B 6183..6189 CDD:409406
Ig strand C 6195..6201 CDD:409406
Ig strand D 6213..6218 CDD:409406
Ig strand E 6219..6225 CDD:409406
Ig strand F 6234..6242 CDD:409406
FN3 <6236..6552 CDD:442628
Ig strand G 6245..6255 CDD:409406
Ig_Titin_like 6570..6650 CDD:409406
Ig strand A 6570..6573 CDD:409406
Ig strand B 6578..6584 CDD:409406
Ig strand C 6590..6596 CDD:409406
Ig strand D 6608..6613 CDD:409406
Ig strand E 6614..6620 CDD:409406
Ig strand F 6629..6637 CDD:409406
FN3 <6630..7006 CDD:442628
Ig strand G 6640..6650 CDD:409406
FN3 <6905..>7189 CDD:442628
FN3 7151..7237 CDD:238020
Ig 7254..7344 CDD:472250
Ig strand B 7271..7275 CDD:409353
Ig strand C 7284..7288 CDD:409353
Ig strand E 7310..7314 CDD:409353
Ig strand F 7324..7329 CDD:409353
Ig strand G 7337..7340 CDD:409353
Ig 7361..7438 CDD:472250
Ig strand B 7365..7369 CDD:409353
Ig strand C 7378..7382 CDD:409353
Ig strand E 7406..7410 CDD:409353
Ig strand F 7420..7425 CDD:409353
FN3 <7421..7762 CDD:442628
Ig strand G 7433..7436 CDD:409353
I-set 7648..7737 CDD:400151
Ig strand B 7665..7669 CDD:409353
Ig strand C 7678..7682 CDD:409353
Ig strand E 7703..7707 CDD:409353
Ig strand F 7717..7722 CDD:409353
Ig strand G 7730..7733 CDD:409353
Ig 7758..7833 CDD:472250
Ig strand B 7761..7765 CDD:409353
Ig strand C 7774..7778 CDD:409353
Ig strand E 7799..7803 CDD:409353
Ig strand F 7813..7818 CDD:409353
Ig strand G 7826..7829 CDD:409353
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016 122/265 (46%)
Ig 8313..8401 CDD:472250 22/105 (21%)
Ig strand B 8329..8333 CDD:409541 1/3 (33%)
Ig strand C 8342..8346 CDD:409541 1/3 (33%)
Ig strand E 8367..8371 CDD:409541 0/3 (0%)
Ig strand F 8381..8386 CDD:409541 0/4 (0%)
Ig strand G 8394..8397 CDD:409541 0/2 (0%)
I-set 8437..8525 CDD:400151 19/87 (22%)
Ig strand B 8454..8458 CDD:409353 1/3 (33%)
Ig strand C 8467..8471 CDD:409353 1/3 (33%)
Ig strand E 8491..8495 CDD:409353 0/3 (0%)
Ig strand F 8505..8510 CDD:409353 2/4 (50%)
Ig strand G 8518..8521 CDD:409353 1/2 (50%)
I-set 8632..8721 CDD:400151
Ig strand B 8649..8653 CDD:409570
Ig strand C 8662..8666 CDD:409570
Ig strand E 8687..8691 CDD:409570
Ig strand F 8701..8706 CDD:409570
Ig strand G 8714..8717 CDD:409570
I-set 8740..8831 CDD:400151
Ig strand B 8757..8761 CDD:409353
Ig strand C 8770..8774 CDD:409353
Ig strand E 8795..8799 CDD:409353
Ig strand F 8809..8814 CDD:409353
Ig strand G 8822..8825 CDD:409353
Ig 8839..8922 CDD:472250
Ig strand B 8856..8860 CDD:409353
Ig strand C 8868..8872 CDD:409353
Ig strand E 8894..8898 CDD:409353
Blue background indicates that the domain is not in the aligned region.

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