Protein Alignment: CYP27B1 and Cyp12b2

• Sequence 1: NP_000776.1
• Gene: CYP27B1
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_611370.2
• Gene: Cyp12b2
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 133/535 (25%)
• Similarity: 230/535 (43%)
• Gaps: 58/535 (11%)

Human     6 KYASRVFHR-----VRW---APELGASLGYR-----------EYHSARRSLADIPGPSTPSFLAE 51
            ||::::.:|     ..|   ...:|.:|..:           |.....||..:|||||....|:.
  Fly     3 KYSNKIIYRNVSGNQLWFNRNSSVGGTLSQQTQLELADSRIDEKWQQARSFGEIPGPSLLRMLSF 67

Human    52 LFCKGGLSRLHELQVQGAAH--FGPVWL--ASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSP 112
            ....|.|...:.:|:.....  :|.::.  ...|....|:...|...|...|.||..|.|.....
  Fly    68 FMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLES 132

Human   113 WTEHRRCR-----QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQ 172
            ...:|:..     :...||.:.:|:||..:|:.:.|:|::.|...:....|:.:..:.:.:|..|
  Fly   133 LNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQ 197

Human   173 RGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMA 237
            |...|  ..|..|...:...:..|.|:.|.|.:|:|.|.....|:.:...:.:...|..:.....
  Fly   198 RNPET--HTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDV 260

Human   238 MPH-WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREE 301
            .|. |..:...| :.:..:.:|.:......::     |.|||..|:.: |.::...|...|...:
  Fly   261 QPSIWTFYKTAG-FKKFLKTYDNITDITSNYI-----ETAMRGFGKND-DGKTKCVLEQLLEHNK 318

Human   302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
            ..|.::   |.::|:||:||.|:.....||.|:|:|..|..|..|:...|.....:...... ..
  Fly   319 KVAVTM---VMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNT-KN 379

Human   367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPA 431
            :|.|:|.:||.||:..:.|||.|:..||:.:..|.:|:.|.|.:.....|.|...|.:.:.|.|.
  Fly   380 MPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPE 444

Human   432 RWLGEGPTP-----------HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ--PEPG 483
            |||.....|           :||..||||||.|:|:|:|:||||::..|.::|..::|.  ||
  Fly   445 RWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVSWLPE-- 507

Human   484 AAPVRPKTRTVLVP 497
             .|:..::..:|.|
  Fly   508 -TPIEYESTIILSP 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	123/481 (26%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	119/468 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3707
Isobase	1	0.950		0	Normalized mean entropy	S4820
OMA	1	1.010
OrthoDB	1	1.010				D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000				T130162
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920