Protein Alignment CYP3A4 and Cyp4p2

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 112/501 - (22%)
• Similarity: 215/501 - (42%)
• Gaps: 85/501 - (16%)

Human    27 THSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMI- 90
            ||...|.|..|          .:.|.|..||..|::            .|.......:..|::|
  Fly    73 THLRQLAKNSG----------DSYLQYSMGFSNFNV------------IDAHNAANILNHPNLIT 115

Human    91 KTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155
            |.|       ::....|     |:::.:..|.:::|...||:|:.||       .:.|:.|:.::
  Fly   116 KGV-------IYNFLHP-----FLRTGVLTATEKKWHTRRSMLTRTF-------HLDILNQFQEI 161

Human   156 LVRNLRR-----EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 215
            .:....:     :.:....|:|||....::::.|..|:.|:.:|.:....|.:..|      |..
  Fly   162 FIAESLKFVSQFQGQNEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRAN------FHI 220

Human   216 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280
            :|.......|.|.      ..:.||:.....:....::|.:.|...|...|.|| .|:..::::.
  Fly   221 IDEGLTRRIVNPL------YWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRV-LLEEELENRR 278

Human   281 SKET----------------------ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323
            :.:|                      |....:.|:.:..:....:..||:|||..|.|.:..::.
  Fly   279 ATQTADDDICVIRKKRFAMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSL 343

Human   324 HPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGM 386
            :...|:...:|| :.:|.:.:......:.::.||...:.||:||:|....:.|...::.|: ||:
  Fly   344 YAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGL 408

Human   387 FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMN 451
            .:||...:.|..:.:||:||||..||:|.||||..:|.....||.|.||.:|.|||||.::|:..
  Fly   409 ILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQE 473

Human   452 MKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497
            ||..::.:|::|...|..:.: .:...:|..|:.:..:.:|:..|:
  Fly   474 MKTLMVVILKHFKILPVIDPK-SIVFQVGITLRFKNKIKVKLVRRN 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	100/454 (22%)
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	106/483 (22%)