Protein Alignment CYP3A4 and Cyp4e2

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 204
• Identity: 47/204 - (23%)
• Similarity: 78/204 - (38%)
• Gaps: 49/204 - (24%)

Human    20 APVPKNGSSSDSSVGEKLGATVADSGVGRTEEYRRRRHTMDKDSRGAAATTTPTEHRFFRRSVIC 84
            |..|..|:...:.:|...|   ...|.|              .|.||.   :|.:.:..
  Fly   103 AAKPHGGNGGGNGIGSGNG---GGGGSG--------------SSNGAG---SPIDEKLL------ 141

Human    85 DSNATALELPGL--PLSIPQPSVPAVVPQSAPPEPHREETLTATV---ASQVSQQPSAAASPGEQ 144
               :....:|.|  .||:...:|.|...|||.....:..:|||::   ||.:|.....|||.|..
  Fly   142 ---SAVASIPNLHTNLSLMMAAVAAAATQSASQNASQLSSLTASLKRSASAMSGGSMVAASQGTT 203

Human   145 AVVGSATTTVPSSTSK-DRPVSQPSLVGSKEEPPPSRSGSGSGGASAKEAQEDRSQQ--QDDIEE 206
            |...:.|.|.|.|:|| :|.|            ||..:.:|:.....:..|:.:.||  :..:::
  Fly   204 ASTTTPTATTPVSSSKRNRAV------------PPLAAPTGALANLIQRQQQIKEQQLKEQQLKD 256

Human   207 LETKAVGMS 215
            .:.||..::
  Fly   257 QQRKATALA 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	37/157 (24%)
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	47/204 (23%)