Protein Alignment CYP3A4 and Cyp4e2

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 129/530 - (24%)
• Similarity: 234/530 - (44%)
• Gaps: 89/530 - (16%)

Human    12 WLLLAVSLVL-LYLYGTHSHGLFKKLGI----PGPTPLPFLGNILSYHKG--------FCMFDME 63
            |.:|.:.|.| |.|........|::..:    .||..||.:||.....|.        |..:
  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWW--- 63

Human    64 CHKKYGK-VWGFYDGQQPVLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKSAISIAED 123
              .:||| .:.|:.|....:.:|....::.:|..:..    .::....|:..:|.:.|..|
  Fly    64 --HQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGS---- 122

Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188
             :|.:.|.:::|.|....|::...::.:.....:::|:..|........::.....::|||..|:
  Fly   123 -KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTA 186

Human   189 FGVNIDSLNNPQDPFVENTK------------KLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241
            .||:|:::.|.....|:..|            .|.|.:.|   :.....:|.....|:.|
  Fly   187 MGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELL---YRLAPDYPAYSRTLKTL----- 243

Human   242 PREVTN-FLRKSVKRMKESRL------EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS 299
             ::.|| .:.|.::..|...:      |.|:| ::.||..::.|     |...:.|:..||..:.
  Fly   244 -QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRK-KMAFLDTLLSS-----TIDGRPLNSKELYEEV 301

Human   300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK---APPTYDTVLQMEYLDMVVN 361
            ..|:|.|::||:|.:||.:|.|:.|.|.|:||.:|...|:.|.   ...|:..:.||:|||:.:.
  Fly   302 STFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIK 366

Human   362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
            |..|::|....:.|..:||..|:|..:|||..:.:....|..:.|.:.:|.||.||||..:..
  Fly   367 EAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP-- 429

Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491
             .|:.|.||.:|||||||.:|||:.:|..:.::::||...|..:
  Fly   430 -GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALD--------------------- 472

Human   492 KVESRDGTVS 501
            ::.|:||.:|
  Fly   473 ELVSKDGYIS 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	118/488 (24%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	117/461 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810