Protein Alignment CYP3A4 and Cyp9b1

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_523645.1
• Gene: Cyp9b1 / 35634
• FlyBaseID: FBgn0015038
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 497
• Identity: 141/497 - (28%)
• Similarity: 255/497 - (51%)
• Gaps: 56/497 - (11%)

Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYG---- 69
            :|..|:||...:||:.:.|.:...|:...:....|.|||||:.:.......|..:..:.|.
  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRH 68

Human    70 -KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRS 131
             |:.|.::.:.|::.|.||.:||.:.||: :..|.|.:......  .:...:::..|:.|:.:||
  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRS 132

Human   132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-----AETGKPVTLKDVFGAYSMDVITSTSFGV 191
            :|:|.|||.|::.|..::.:.....:.:|:..     .|....:.:|.:....|.|||.:|:||:
  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFGL 197

Human   192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV--- 253
            .::|.::|::.|....|.|              .|...:|.|:.: :|:...:|.||.:.::
  Fly   198 KVNSFDDPENEFHTIGKTL--------------AFSRGLPFLKFM-MCLLAPKVFNFFKLTIFDS 247

Human   254 ------KRMKESRLEDTQKH---RVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309
                  .|:....::..:||   |.|.:||:::::.    ||....:|.|:|||..||.||.:|.
  Fly   248 TNVEYFVRLVVDAMQYREKHNITRPDMIQLLMEAKK----ESKDNWTDDEIVAQCFIFFFAAFEN 308

Human   310 TSSVLSFIMYELATHPDVQQKLQEEI----DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370
            .|:::....|||..:.|:|::|.||:    :|:  ..||.|||...:|.|:|||::|:||.:.::
  Fly   309 NSNLICTTAYELLRNLDIQERLYEEVKETQEAL--KGAPLTYDAAQEMTYMDMVISESLRKWTLS 371

Human   371 MRLERVCKKDVEING-----MF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429
            ...:|:|.||..:..     :| ...|..:.||...||.|.:::.:|::|.|||||::.|.::.|
  Fly   372 AAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIP 436

Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471
            |.|.|||.|||:|||.|:|:|..|..|..::.|:..:....|
  Fly   437 YTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	133/467 (28%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	132/462 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870